Spectrophotometric Determination for Salbutamol Sulphate drug by Oxidation Coupling with 4-Aminoantipyrine
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Abstract
This research introduce simple & fast spectrophotometric method for determination of Salbutamol Sulphate drug by Oxidation Coupling with 4-aminoantipyrine(4-AAP) and NaIO4 as Oxidant reagent. Purple color solution is found which give maximum absorbance at 506 nm.
The optimum conditions of the method are as the follow :
(2 µg/ml, 2.4X10-3 M and 4.8X10-3 M) concentration of drug ,reagent and oxidation reagent respectively with 4min as a reaction time at room temperature in neutrality solution.
The results of statistical treatment of linear concentration range (0.4- 40) µg/ml are: r= 0.9984, Detection limit = 0.0317 µg/ml and Molar absorption coefficient =19028 L/mol.cm , This method is applied successfully for the determination drug in pharmaceutical formulation with ratio 1:1.
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