Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction
Article Sidebar
Main Article Content
Abstract
A simple and sensitive spectrophotometric method was developed for the determination of Methyl Paraben via oxidative coupling with the 2,4-Dinitrophynel hydrazine in the presence of N-bromosuccinimid in a basic medium, Absorbance of the obtained coloured products was measured at the corresponding optimum wavelengths (600 nm), Beer’s law is obeyed over the concentration of 2.0-20 μg.ml-1, and The molar absorptivity of (6253 L.mole-1.cm-1), Sandell,s sensitity index of (0.02433 µg.cm-2). The detection limits were (0.34 μg.ml-1), with a linear regression correlation coefficient of (0.9947) and recovery range from (98.96–103%). The proposed method has been applied successfully to determine Methyl Paraben in pharmaceutical preparations and cosmetic formulations.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1- The American extra pharmacopoeia; 2005 David Winston , Herbalist AHG.
2- F. Giordano and R. Bettini, C. Donini, A. Gazzaniga, M. R. Caira, G.C. Zhang and D. J. Grant, ''Physical properties of parabens and their mixtures: solubility in water, thermal behavior, and crystal structures'', J. Pharm. Sci., 88(11), 1210-6 (1999).
3- S. Taylor and G. Burdock, ''Evaluation of the health aspects of Methyl Paraben areview of the Published literature'', J. food . chem. Toxi. , 40(10), 1335-1373 (2002).
4- M. Anderson and K. Kitagaito, S. Lee and E. Martinez; Paraben , CHEM355 – Organic Chemistry II, 1-13, (2011).
5- R. EJ, Parker and J, Odum,''Some alkyl hydroxy benzoate preservatives(parabens)a are estrogenic'', J. Toxicol Appl pharma.,153(1), 9-12 (1988).
6- P. W.,Harvey,"Paraben, Oestrogen under arm cosmetics and breast cancer. Aperspective on hypothesis'', J. Appl. Toxi., 23(5), 285-288 (2003).
7- S. Dhahir and H. Hussien, ''Spectrophotometric Determination of methyl paraben in pure and
pharmaceutical Oral Solution'', J. Advan. Nat. Sci., 6(4), (2013).
8- B. Saad and Md. Fazlul Bari, M. Idiris Saleh and K. Ahmed, Mohd,''Stimultaneous determination of preservatives(benzoic acid scorbic acid methyl paraben and propyl paraben) in food stuffs using HPLC'', J. chromate. Phy. A., 1073(1-2), 393-397 (2005).
10- A. Myint, Q. Zhang and L. Liu and H. C. ''Flow injection – chemiluminescence determination of paraben preservative in food Safety'', J. Anal. Chem. Acta, 517(1-2), 119-124 (2004).
11- Q. Zhang, MeiLian, L. Liu and H. Cui,''High- performance Liquid chromatographic assay of parabens in Wash- off Cosmetic products and food using chemiluminesscence detection'', J. Anal. Chem. Acta, 537 (1-2), 31-39 (2005).