Role of IL-6 in urinary tract infection among diabetic and non- diabetic patients
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Abstract
Urinary tract infection is the presence of microorganisms mostly bacteria in the urinary tract, one of the reasons that increases the risk of infection is diabetes, which is the most common metabolic disorder that is increasing at an alarming rate all over the world, due to high blood sugar caused by weak immunity leading to This results in damage to neutrophil function and decreased antibacterial activity in urine and thus bacteriuria.The study included 118 samples (73 samples for diabetic patients and suffering from urinary tract infection, and 45 samples for UTI without diabetes), where the level of interleukin-6 was measured in these two groups and compared with the control group (20 samples), and the level of this immune cytokine was compared at Infection with different bacterial species.
The level of interleukin-6 was high in patients with urinary tract infection who did not suffer from diabetes, which reached (24.1 ± 8.75) ng/ml compared to the control samples whose level was (0.763 ± 4.18) ng/ml and with a significant difference (0.01>p). . There is a significant increase for IL-6 in patients with urinary tract infection without diabetes (2.58±9.77) compared to the control samples whose level reached (0.551±3.79) at a significant level (P>0.01).
The highest level was when infected with E.coli and its level was (3.92 ± 17.51) ng/ml in normal UTI patients and (2.571 ± 13.43) ng/ml in diabetic patients.
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