Study the relationship between Apelin and some biochemical parameters in patients with kidney diseases
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Abstract
The study aimed to determine the effect of the lack of peptide apelin in the pathogenesis of kidney patients and the positive impact when increasing its concentration in the body and protect the body from various diseases.
The study included 57 patients of different ages and were compared with the control group, which included 25 samples.Through the study, which was conducted and when measuring the concentration of Apelin show that there is a significant decrease (P≤0.01) at a concentration of Apelin in people who suffer from kidney disease compared with the control group, which was Apelin concentrations with in the normal range, and it has been Measuring range of biochemical variables to find a statistically significant correlation between their concentrations and the concentrations of Apelin and results of the study follows :The concentration of nitrogen compounds and their relationship with Apelin levels: found high significant (P≤0.01) at each concentration of urea, creatinine and uric acid in people who are suffering from various kidney diseases compared with the control group, which was within normal of biochemical variables. And their relationship was a correlation with the concentration of Apelin is an inverse relationship. The concentration of proteins in the blood serum concentrations and their relationship Apelin: found a significant increase (P≤0.01) in the concentration of each of the total protein and globulin in people suffering from various kidney disease compared with the control group, which was within normal concentrations of the protein that resides in the body, While the results did not show any significant differences in the concentration of albumin between patients and control group. and their relationship with apelin concentration is an inverse.
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References
1-Zeng XJ, Zhang LK, Wang HX. et al (2009). Apelin protects heart against ischemia/reperfusion injury in rat. Peptides 30:1144–1152.
2-Hus-Citharel A, Bouby N, Frugiè re A, Bodineau L, Gasc JM, Llorens-Cortes C. (2008). Effect of apelin on glomerular hemodynamic function in the rat kidney. Kidney Int .74(4):486-94.
3-Kleinz MJ, Davenport AP. (2004). Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regul Pept. 118(3):119-125.
4-Kleinz MJ, Skepper JN, Davenport AP. (2005). Immunocytochemical localization of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept. 126(3):233-40.
5-Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY. (2003). Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 84(5):1162-72.
6- Lee DK, Cheng R, Nguyen T. et al (2000). Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74(1):34-41.
7-O’ Carroll AM, Selby TL, Palkovits M, Lolait SJ. (2000). Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. Biochim Biophys Acta. 1492(1):72-80.
8-Kleinz MJ, Davenport AP. (2005). Emerging roles of apelin in biology and medicine. Pharmacol Ther.107(2):198-211.
9-Nishida M, Hamoaka K. (2013). The apelin-APJ system: its role in renal physiology and potential therapeutic applications for renal disease. OA Nephrology . 01; 1(1):7.
10- Jia YX, Pan CS, Zhang J. et al (2006) Apelin protects myocardial injury induced by isoproterenol in rats. Regul. Pept., 133 (1-3): 147-54.
11- Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S. (2004). Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem. 279(25):26274-9.
12- El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D, Llorens-Cortes C. (2004) Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. J. Neurochem., 90 (6): 1290-301.
13-Cheng X, Cheng XS, Pang CC. (2003) Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. Eur J Pharmacol., 470: 171-175.
14-Berry MF, Pirolli TJ, Jayasankar V. et al. (2004) Apelin has in vivo inotropic effects on normal and failing hearts. Circulation., 110: II187-II193.
15- Atluri P, Morine KJ, Liao GP .et al. (2007) Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression. Cell. Mol. Biol. Lett., 12 (1): 127-38.
16-Maguire JJ, Kleinz MJ, Pitkin SL, Davenport AP. (2009) [Pyr1] apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension, 54 (3): 598-604.
17- De Mota N, Reaux-Le Goazigo A et al(2004). Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Natl Acad Sci. USA;101(28):10464-9.
18- Boucher J, Masri B, Daviaud D. et al. (2005) Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology, 146 (4): 1764-71.
19- Glassford AJ, Yue P, Sheikh AY. et al (2007) HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Am. J. Physiol. Endocrinol. Metab., 293 (6): E1590-6.
20- Kunduzova O, Alet N, Delesque - Touchard N.et al. (2008) Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes. FASEB J., 22 (12): 4146-53.
21- Kralisch S, Lossner U, Bluher M. et al (2007) Growth hormone induces apelin mRNA expression and secretion in mouse 3T3-L1 adipocytes. Regul. Pept., 139 (1-3): 84-9.
22-Daviaud D, Boucher J, Gesta S. et al. (2006) TN Falpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J., 20 (9): 1528-30.
23- Higuchi K, Masaki T, Gotoh K. et al (2007) Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Endocrinology, 148 (6): 2690-7.
24- Cayabyab M, Hinuma S, Farzan M. et al. (2000) Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. J Virol., 74: 11972-11976.
25- Zou MX, Liu HY, Haraguchi Y. et al (2000) Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett., 473: 15-18.
26- Devic E, Rizzoti K, Bodin S, Knibiehler B, Audigier Y.(1999). Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 84 (1-2): 199-203.
27-Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, et al. (2000). Molecular and functional characteristics of APJ: tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 275 (28): 21061-7.
28- Tietz N.W. (1987). Fundamentals of clinical chemistry. 3rd ed. W.B. Saunders company, USA.
29-Zhuo L. (2013). Correlationship of plasma apelin-12 with blood renal pressure and early renal damage in hypertensives. R.544.1.
30-Zhu P.; Huang F.; Yan Y.; Chen F.; Li Q. (2013). Plasma apelin level, blood pressure and cardiovascular risk factors in coastal chinese population. Annals of Medicine 45:494-498
31-Fukushima H, Kobayashi N, Takeshima H, Koguchi W, Ishimitsu T. (2010). Effects of olmesartan on Apelin/APJ and Akt/eNOS pathway in Dahl rats with end-stage heart failure. J Cardiovasc Pharmacol .55(1):83-8.
32-Sagiroglu T, Torun N, Yagci M, Yalta T, Sagiroglu G, Oguz S. (2012). Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study. Exp Ther Med. 3(5):908-14.
33-Ostfeld R., Spinelli M., Mookherjee D., et al. (2010). The association of blood urea nitrogen levels and coronary artery disease.
34-Schrier RW. (2008). Blood urea nitrogen and serum creatinine not married in heart failure. Circ Heart Fail; 1:2-5.
35-Schrier RW, Abraham WT. (1999). Hormones and hemodynamics in heart failure. N Engl J Med.;341:577–585.
36-Berl T, Schrier RW. (2002). Disorders of water metabolism. Chapter 1. In Schrier RW, ed. Renal and Electrolyte Disorders. 6th ed. Philadelphia: Lippincott Williams and Wilkins:1– 63.
37-Karadag S.; Ozturk S.; Gursu M. et al (2014). The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker ?. BMC Nephrology 15:18.
38-Ul Amine N.; Mahmood T. R.; Asad M.J.; Zafar M. and Raja A.M. (2014). Elvaluating urea and creatinine levels in chronic renal failure pre and post dialysis a prospective study. Vol2.No2.
39-Levey A S, Eckardt U and Tsukamoto Y. (2005). Definition and classification of chronic kidney disease: a position statement from Kidney Disease. Kidney International; 67: 2089–2100.
40-Ostfeld, R., Mookherjee, D., Spinelli, M., et al. (2006). A triglyceride/high-density lipoprotein ratio . or = 3.5 is associated with an increased burden of coronary artery disease on cardiac catheterization. JCMS 1:13-5.
41-Kirtane, A.J., Leder, D.M., Waikar, S.S., et al. (2005). Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates. J Am Coll Cardiol 45:1781-86.
42-Santulli G, Cipolletta E, Sorriento D, et al (2012) Cam MK4 gene deletion induces hypertension. Journal of American Heart Association; 1(4): e001081.
43-Santulli G, Trimarco B and Iaccarino G. (2013). G-protein-coupled receptor kinase 2and hypertension: molecular insights and pathophysiological mechanisms High Blood Pressure Cardiovascular Prevention; 20(1): 5-12.
44-Silva A.P.,Fragoso A., Silva C. et al. (2013). What is the role of apelin regarding cardiovascular risk and progression of renal disease in type 2 diabetic patients with diabetic nephropathy? 247649.
45-Angelova P., Kamenov Z., Tsakova A. (2014). Apelin and testoteron levels in men with metabolic syndrome. 4,35-43.
46-Perrone R.D., Madias N.E., Levey A.S. (1992). Serum creatinine as an index of renal function : new insight into old concepts. Vol. 38 no. 10.
47-Suki WN. (1989). Renal hemodynamic consequences of angiotensin-converting enzyme inhibition congestive heart failure. Arch Intern Med. 149:669–673.
48-Medeiros PJ, Villarim Neto A, Lima FP, et al. (2010). Effect of sildenafil in renal ischemia/ reperfusion injury in rats. Acta Cir Bras. ;25:490–495
49-El-Shehaby A.M., El-Khatib M.M., Battah A.A., and Roshdy A. R. (2010). Apelin: a potential link between inflammation and cardiovascular disease in end stage renal disease patients, Scandinavian Journal of Clinical and Laboratory Investigation, vol. 70, no. 6, pp. 421–427.
50-Kuroczycka-Saniutycz E., Porowski T., Protas P.T. et al (2014). Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis? Pediatr nephrol 30: 797-803.
51-Banakdaran S., Hami M., Shakeri M.T. (2011). Hyperuricemia and albuminuria in patients with type 2 diabetes mellitus. IJKD 5:21-4.
52-Cirillo P., Sato W., Reungiui S. et al. (2006). Uric acid the metabolic syndrome and renal disease. J Am Soc Nephrol 17: S 165-S-168.
53-Amin ul-Haq. et al. (2010). Association of serum uric acid with blood urea and serum creatinine. Pak j physiol,6(2).
54-Khosla U, Zharikov S, Finch JL. et al (2005). Hyperuricemia induces endothelial dysfunction. Kidney Int 67: 1739–1742.
55-De Oliveira E.P.&Burini R.C.(2012). High plasma uric acid concentration: causes and consequences. Metabolic syndrome 4:12.
56-Nguedia Assob J.C., Ngowe M.N., Nsagha D.S. et al (2014). The relationship between uric acid and hypertension in Adults in Fako division, SW region Cameroon.J. Nutr food Sci. 4:1.
57-Zhang W, Sun K, Yang Y, Zhang H, Hu FB, et al. (2009) Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis. Clin Chem 55: 2026-2034.
58-Alisheikh S., Lanyan G., Cheng X.K. et al. (2011). Clinical significance of plasma Adiponectin and Apelin in coronary heart disease patients accompanied with abnormal glucose metabolism. Journal of Clinical Cardiology. R541.4.
59-Than A.;Zhang X.; Khee-shing Leow M.;et al. (2014). Apelin attenuates oxidative stress in human
adipocytes. The journal of biological chemistry. Vol 289 No.6 pp
60-Saravi M., Alizadeh R. (2005). Elevated serum uric acid levels are association with diastolic dysfunction in patients with congestive heart failure. Diastolic function.
61-Peterson J.C., Adler S., Burkart J.M. et al. (1995). Blood pressure control, proteinuria and progression renal disease: the modification of diet in renal disease study. 123(10): 754-754.
62-Jafar T.H., Stark P.C., Schmid C.H. et al. (2003). Progression of chronic kidney disease : the role of blood pressure bcontrol, proteinuria and Angiotensin-converting enzyme inhibition. Vol. 139 No.4.
63-Iseki K., Ikemiya Y., Iseki C. and Takishta S. (2003). Proteinuria and risk of developing end-stage renal disease. Kidney International Vol. 63, pp. 1468-1474.
64-Sarafidis P.A., Ruilope L.M. (2013). Blood pressure targets for patients with chronic kidney disease. ESH 14: No. 55.
65-Szu Y.L., Chiao L.C. Wu C.Y., Shing J.L. (2014). Proteinuria predicts postcardiotomy acute kidney injury in patients with preserved glomerular filtration rate. 10.1016.
67-Yavuz Y.C.; Sevinc C.; Deniz M.S. et al (2015). The role of apelin-13 in prpgression of chronic kidney disease. 9: 369-73.
68-Gekle M. Renal tubule albumin transport. (2005). Annu Rev Physiol 67: 573–594.
69-Day RT, Cavaglieri RC, Feliers D. (2013). Apelin retards the progression of diabetic nephropathy. Am J Physiol Renal Physiol; 304(6):F788-800.
70-Akcilar R, Turgut S, Caner V. et al. (2013). Apelin effects on blood pressure and RAS in DOCA-salt-induced hypertensive rats. Clin Exp Hypertens 35, 550–557.
71-Yuste C, Barraca D, Aragoncillo I, et al. (2013). Factors related with the progression of chronic kidney disease. Nefrologia. 33:685-91.
72-Dogan I. (2014). The relationship between serum of apelin-13 and inflammation in peritoneal dialysis patients. Nephrol. Dial, Transplant.
73-Barahimi H., Najafi I., Esmailian R. et al. (2011). Distribution of Albuminuria and low glomerular filtration rate in a Rural area shahreza Iran. Ijkd 5:374-9.
74-Brinkkoetter P.T., Ising C. and Benzing T. (2013). The role of the podocyte in albumin filtration. Nephron 9,328-336.
75-Baldan-Martin M., Cuesta F.D., Alvarez-Llamas G., et al. (2015). Prediction of development and maintenance of high albuminuria during chronic renin-angiotensin suppression by plasma proteomics. International journal of cardiology Vol. 196 pp170-177.
76-Marshall SM. (2005). The podocyte: a major player in the development ofdiabetic nephropatohy? Hrmone and metabolic research. Hormon Stoffwechselforschung 37, Suppl 1: 9–16.
77-Ljubicić N., Bilić A., Babić Z., Roić D., Banić M. (1992). The significance of low levels of total proteins, albumins, globulins and complement factors in ascitic fluid and the development of spontaneous bacterial peritonitis in patients with liver cirrhosis. Lijec Vjesn. 114(9-12):213-5.
78-Adamu K.M. and Kori-Siakpere O. (2011). Effects of Sublethal Concentrations of Tobacco (Nicotiana Tobaccum) Leaf Dust on Some Biochemical Parameters of Hybrid Catfish (Clarias gariepinus and Heterobranchus Bidorsalis). Braz. Arch. Biol. Technol. Vol.54 No.1: pp. 183-196.
70-Ljubicić N., Bilić A., Babić Z., Roić D., Banić M. (1992). The significance of low levels of total proteins, albumins, globulins and complement factors in ascitic fluid and the development of spontaneous bacterial peritonitis in patients with liver cirrhosis. Lijec Vjesn. 114(9-12):213-5.
79-Shankland S.J. (2006). The podocyte’s response to injury: Role in proteinuria and glomerulosclerosis. Kidney International. 69,2131-2147