The effect of different concentrations of metformin drug on the concentration of glucose and lipid profile in the male rats induced diabetes by alloxan.
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Abstract
The present study aimed to find out the effect of Metformin drug on some of biochemical parameters, including Glucose and lipid profile: Cholesterol, Triglycerides, High density lipoprotein HDL-CH, and low density lipoprotein LDL-C Male albino rats were used in this study.
The results showed that the development of diabetes induced by alloxan led to a significant increase in the levels of glucose, cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) compared with the control group. Treatment of animals in the third and fourth groups with metformin at two different concentrations of (500,850) mg led to a significant decrease in glucose and cholesterol levels, compared with the aloxan group, the results were similar to the control group, and the treatment resulted in a significant decrease in triglycerides and low-density lipoproteins (LDL-C) compared with the alloxan group and gave results comparable to the control group (healthy controls).
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