Determination of Interleukins 2, 6 and some liver enzymes in gallstone patients' pre- and post- cholecystectomy
Article Sidebar
Main Article Content
Abstract
This study was conducted in Tikrit Teaching Hospital to elevate the serum concentration of Interleukins 2, 6 and the specific activity of liver enzymes for the gallstone patients who undergo cholecystectomy.
This study included 120 patients (92 female and 28 male) aged between 15-65.
The results showed that there is a significant difference in the Interleukins 2, 6 levels before and after the surgery; also there were significantly differences (p≤ 0.01) in specific activity of liver enzyme of liver in male and female before and after cholecystectomy.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1. Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gas-troenterology. (1999). 117:632-639.
2. Shaffer EA. Gallstone disease: Epidemiology of gallbladder stone disease. Best Pract. Res. Clin. Gastroenterol. (2006). 20(6): 981-996.
3. Russo MW., Wei JT, Thiny MT, Gangarosa LM, Brown A, Ringel Y et al. Digestive and liver disease statistics. Gastroenterology. (2004). 126(5): 1448-1453.
4. Selvi, RT., Sinha P, Subramaniam PM, Konapur PG, Prabha CV. A. Clinic pathological Study of Cholecystitis With Special Reference to Analysis of Cholelithiasis. International journal of Basic Medical Science. (2011). 2 (2): 68-72.
5. Sakorafas G., Anagnostopoulos G, Stafyla V, et al. Elevation of serum liver enzymes after laparoscopic cholecystectomy. N Z Med J. (2007). 118: U1317.
6. Beth, Dawson and Robert G Trapp. Basic and clinical biostatistics.4th ed. (2004). New York: Lange Medical Books/ McGraw – Hill Medical Publishing Division; 83-85, 149-154 and 369.
7. Strasberg SM. Acute calculous cholecystitis. New Engl. J. Med.; (2008) 358: 2804e11.
8. Rochman Y., Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat. Rev. Immunol. (2009): 9:480–490.
9. Savard CE., Blinman TA, Choi HS, Lee SK, Pandol SJ, Lee SP. Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: response to bacterial lipopolysaccharides. (2002). 2:23.
10. Pei-Yuan Su a,c, Shih-Jen Liu b,g, Yi-Hua Chen g, Shun-Sheng Wu c Yao-Li Chen d, Jhin-Ran Ke d, Cheng-Yuan Peng e, Yuh-Pyng Sher a,f. Increased IL-8 and IL-1b in the bile of acute cholecystitis patients. China Medical University. Published by Elsevier Taiwan LLC. Bio. Med. (2013): 181- 185.
11. Rodriguez-Sanjuan JC, Arruabarrena A, Sanchez-Moreno L, Gonzalez-Sanchez F, Herrera LA, Gomez-Fleitas M. Acute cholecystitis in high surgical risk patients: percutaneous cholecystectomy or emergency cholecystectomy. Am. J. Surg.; (2012) 204: 9-54.
12. Rongione AJ., Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin-10 protects
against lethality of intra-abdominal infection and sepsis. J. Gastrointest Surg. (2000); 4(1):60-70.
13. Hildebrandt U., Kessler K, Plusczyk T, Pistorius G, Vollmar B, Menger MD. Comparison of surgical stress between laparoscopic and open colonic resections. Surg. Endosc. (2003); 17(2):242-6.
14. Bolke E., Jehle PM, Graf M, et al., Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release.Shock. (2001). 16:334–339.
15. Nowell, MA., Richards PJ, Horiuchi S, Yamamoto N, Rose-John S. Topley N., Williams AS, Jones SA. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein. J. Immunol., (2003). 171: 3202-3209.
16. Malek TR. The biology of interleukin-2. Annu. Rev. Immunol. (2008): 26: 453-479.
17. Mrksić M., Cabafi Z, Feher I, Mirković M Zdravstveni. Surgical trauma in laparoscopic and classical cholecystectomy centar Dr. Gere Istvan, Senta Medicinski Pregled. (2001); 54(7-8):327-331.
18. Al-kataan M. Abdulkafour. Study of lipid profile and some other biochemical barometers in gallstone patients before and after cholecystectomy; thesis, college of Science, Mosul University. (2006). Mosul. Iraq: 40-65.
19. Hafiz, M. Aslam, Shafaq Saleem, Muhammad M. Edhi, Hiba A Shaikh, Jehanzeb D. khan, Mehak Hafiz and Maria Saleem. Assessment of gallstone predictor: comparative analysis of ultrasonographic and biochemical parameter. A slam International Archives of Medicine, (2013). 6:17.
20. Zare M., Kargar S, Akhondi M, Mirshamsi MH. Role of liver function enzymes in diagnosis of choledocholithiasis in biliary colic patients. Acta. Med. Iran. (2011)49(10):663–666.
21. Erhan H. Güven, Süleyman Oral. Liver Enzyme Alterations after Laparoscopic Cholecystectomy. J. Gastrointestin Liver Dis. (2007): Vol.16 No 4, 391-394.
22. Neha Jindal, Gurjit Singh, Iqbal Ali, Gaurav Sali, Raghuveer Reddy. Effect of cholelithiasis and cholecystectomy on serum lipids and blood glucose parameters. (2013) Volume: 3/ Issue: 2 Page: 97-101.
23. Alsafi MA. Variations in dietary intake between newly diagnosed gallstone patients and controls. Pakistan Journal of Nutrition; (2005). 4: 1-7.
24. Halevy A., R. Gold-Deutch, M. Negri, G. Lin, N. Shlamkovich, S. Evans, D. Cotariu, E. et al. Are Elevated Liver Enzymes and Bilirubin Levels Significant After Laparoscopic Cholecystectomy in the Absence of Bile Duct Injury? ANNALS OF SURGERY. (1994). Vol. 219, No. 4, 362-364. 231.
25. Michale, B., Edward P. Fody, Larry E. and Schoef F. Clinical chemistry. 6th ed. (2010). Williams and Wilkins, Philadelphia, PP: 336-356.
26. Tawfiq B. Fadil. Estimating of some biochemical parameters in patient with gallstone. Collage of
medicine. Tikrit University. (2011). Salahaddin. Iraq. 25-30.
27. Yang MH., Chen TH, Wang SE, Tsai YF, Su CH, Wu CW, Lui WY, Shyr YM. Biochemical predictors for absence of common bile duct stones in patients undergoing laparoscopic cholecystectomy. Surg. Endosc. (2008). 22: 1620-1624.
28. Havill LM., Rogers J, Cox LA, et al. QTL with pleiotropic effects on serum levels of bone- specific alkaline phosphatase and osteocalcin maps to the baboon ortholog of human chromosome. J. Bone Miner Res; (2006). 21:1888-1896.