Histological changes in the motoneurons induced at L6 & L7 segments of spinal cord in different age group in rabbits
Main Article Content
Abstract
The aim of the present study was to observe the tissue changes that occur in motoneurons in the L6 and L7 segments of the ventral horn of the spinal cord in different age groups in rabbits. Fifteen Rabbits were divided into three groups of equal number according to their age (weaning, maturation, Adult). L6 and L7 were removed (after sacrifice the rabbits) from the spinal cord and slice histologically to be examined under light microscope. Comparison was made in diameters of neurons and their numbers in different age groups and the results showed a significant decrease in the number of motor neurons and a significant increase in diameters with advancing age.
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1. Lexell, J. Human aging, muscle mass and fiber type composition. J. Gerontol. 1995,50A (Special Issue): 11–16.
2. Larsson L., Ansved T. Effects of ageing on the motor unit. Prog. Neurobiol. 1995,45:397–458.
3. Verdu E., Ceballos D., Vilches J.J., Navarra X., Influence of aging on peripheral nerve function and regeneration. J. P. N. S., 2000,5:191-208.
4. Morimoto M. General physiology of rabbit. In: Houdebine LM, Fan J. Rabbit Biotechnology: Rabbit Genomics, Transgenesis, Cloning and Model.springer Science and business media ,B.V.; 2009. p. 27-33.
5. Mohammad FK. Laboratoty Guide in Toxicology: a technical manual for veterinary medical and related health sciences students. 2nd ed. 2010. P. 8.
6. Khan AM, Dilkash NA, Khan MA, Faruqi NA. Morphologically atypical cervical dorsal root ganglion neurons in adult rabbit. Biomedical Research 2009;20(1): 45-49.
7. Jackson M, Ganel R, Rothstein JD, Model of Amylotrophic Sclerosis. Curent Protocol in Neuroscience;2002 Nov 1.
8. Abdul-Jabbar, Haier M, Naqvi A. Motor and sensory neurons of the rat. A Horseradish peroxidase study. Professional Med J., Jun. 2007 Jun;14(2): 328-336.
9. Terao S, Sobue G, Hashizume Y, Li M, Inagaki T, Mitsuma T. Age related changes in human spinal ventral horn cells with special reference to loss of
small neurons in the intermediate zone: a quantitative analysis. Acta Neuropathol 1996 Aug;92(2):14-109.
10. Cary NC. SAS, Institute. SAS U Version 6th ed. SAS Institute Inc; 2001.
11. Bowen R.L., Atwood C.S. Living and Dying for Sex. Gerontology. 2004,50 (5): 265–90.
12. Lexell J. Evidence for Nervous System Degeneration with Advancing Age. Am. Soc. Nut. Scien. 1997.
13. Pollin M.M., McHanwell S. and Slater C.R., The effect of age on motor neurone death following axotomy in the mouse. Development. 1991;112:83-89.
14. Arvanian V.A., Horner Ph. J., Gage F.H., and MendellL.M. Chronic Neurotrophin-3 Strengthens Synaptic Connections to Motoneurons in the Neonatal Rat. J. Neurosci., September 24, 2003; 23 (25): 8706–8712.
15. Yan Q, Matheson C, Lopez OT. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature. Jan, 1995, 26; 373 (6512): 341-4. 16. Ptacek J.M.& Dubin L.F. Developmental changes in neuron size and density in the visual cortex and superior colliculus of the postnatal golden hamster. J Comp Neurol. 1974; 158 (3): 237–242. 17. Baulac M, Meininger V. Postnatal development and cell death in the sciatic motor nucleus of the mouse. Exp Brain Res. 1983;50(1):107-16.