Estimation of Salivary Resistin, malondialdehyde and Lipid Profile levels in patients with Diabetes Mellitus
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Abstract
The present study is designed to verify the changes of resistin, malondialdehyde (MDA), glucose and lipid profile in type2 diabetes mellitus.
This study was carried out during the period from November 2013 till January 2014, on 96 subjects: 57 diabetic patients (11 males and 46 females, aged between 33 and 60 years, with a mean age of 40.32) and 39 healthy controls (24 males and 15 females, aged between 40 and 59 years, with a mean age of 47.43), who attended :outpatient, Health care center, and Emergency Department in Tikrit Teaching Hospital.
The results showed a significant increase in the salivary glucose, total cholesterol (TC), triglycerides (TG) resistin, and MDA level in diabetic patients compared to controls, while significant decrease in salivary HDL in diabetic patients compared to controls.
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References
[1] Saravanan G and Ponmurugan P. Ameliorative potential of S-allylcysteine: Effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Experimental Toxicology Pathology. 2011; (in press) DOI:10.1016/j. etp2010. 12007.
[2] Claire M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, C.M. Wright, H.R. Patel, R.S. Ahima, M.A. Lazar, The hormone resistin links obesity to diabetes, Nature 409 (2001) 307–312
[3] Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, Macphee CH & Smith SA. Resistin is expressed in human macrophages and directly regulated by PPAR[gamma] activators. Biochemical and Biophysical Research Communications 2003; 300 :472–476. [4] S. Kaser, A. Kaser, A. Sandhofer, C. F. Ebenbichler, H. Tilg, and J. R. Patsch, “Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro,” Biochemical and Biophysical Research Communications. 2003; 309( 2):286–290. [5] Fonseca-Alaniz MH, Takada J, Alonso-Vale MIC, Lima FB. Adipose tissue as an endocrine organ: from theory to practice. J Pediatr (Rio J). 2007; 83(5): 192-203. Singhal, N.S., M.A. Lazar, and R.S. Ahima, Central resistin induces hepatic insulin resistance via neuropeptide Y. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. 27(47): 12924-32. [6] Jinhua Yin, Hongfei Gao, Jing Yang, Lu Xu, Ming Li. Measurement of Salivary Resistin Level in Patients with Type 2 Diabetes International Journal of Endocrinology. [MSc Thesis]. 2012. [7] Pappa, A.K. Papazafiropoulou, D. Mostrous,S. Pappas. Serum resistin, metabolic pathology and diseases in children and. Αρχεία Ελληνικής Ιατρικής 2013, 30(6):700–706. [8] Garima Shakya, Charanraj Goud, Sankar Pajaniradje, Rukkumani Rajagopalan. Protective Role of Wheat Grass on Oxidative Stress in Streptozocin Induced Type 2 Diabetic Rats. Int J Pharm Pharm Sci.,4( 3), 415-423. [9] Biljana Andjelski-Radičević, Radica Dožić, Tatjana Todorović, Ivan Dožić. Biochemical Markers in Saliva of Patients with Diabetes Mellitus. Serbian Dental Journal. 2012, 59( 4). [10] Anđelski-Radičević B, Mirković S, Todorović T, Zelić O. Promene biohemijskog sastava salive kod dijabetičara. Stomatološki glasnik Srbije. 2006; 53:209-16.
[11] Mata AD, Marques D, Rocha S, Francisco H, Santos C, Mesquita MF, et al. Effects of diabetes mellitus on salivary secretion and its composition in the human. Molecular Cell Biochemistry. 2004; 261:137-42. [12] K. Mahadevan1 and S. Velavan1. Assessment of salivary lipid peroxidation and protein oxidation status in patients with diabetic and oral cancer. International Journal Medicine Biochemistry science. 2012; 1(4): 66 – 68. [13] Roeschlau P., Bernt E, and Gruber W.A., Estimation of serum cholesterol; clinical biochemistry. 1974, 12(226).
[14] Fossati P, Prencipe L. Serum triglycerides determined colonmetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry. 1982;28:2077-80.
[15] Burstein M., Scholnick H.R., Morfin R. Rapid method for isolation of lipoproteins from human serum by precipitation with polyanions. Journal of Lipid Research. 1970:11, 583- 595. [16] McTernan PG, Fisher FM, Valsamakis G, Chetty R, Harte A, McTernan CL, et al. Resistin and type 2 diabetes :regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. Journal Clinical Endocrinolology Metabolism. 2003,88:6098–6106.
[17] Forbat LN, Collins RE, Maskell GK, Sonksen PH. Glu-cose concentrations in parotid fluid and venous blood of patients attending a diabetic clinic. Journal Royal Social Medecine. 1981; 74: 725-728.
[18] Darwazeh AM, Macfarlane TW, McCuish A, Lamey PJ. Mixed salivary glucose levels and candidal carriage in patients with diabetes mellitus. Journal Oral Pathology Medicine, 1991; 20(6): 280.
[19] Ben-Aryeh H, Cohen M, Kanter Y, Szargel R, Laufer D. Salivary composition in diabetic patients. Journal Diabetes Complications 1988; 2 (2): 96-99.
[20] Pal P, Desai NT, Kannan N, Masur VN, Daniel MJ, Bhatt N. Estimation of Salivary glucose, salivary amylase, salivary total protein and periodontal microflora in Diabetes mellitus. JIDA 2003; 74: 143-149 .
[21] Shehla A,Muniza Y, P.Q. R. Siddiqui, Junaid A, Sali-vary glucose concentrations in patients with diabetes mellitus – a minimally invasive technique for monitoring blood glucose levels. Pakistan Journal of Pharmaceutical Sciences 2001; 14(1): 33-37.
[22] Soares MSM, Batista-Filho MMV, Pimentel MJ, Pas-sos IA, Chimenos-Küstner E. Determination of salivary glucose in healthy adults. Medicine Oral Patololgy. 2009 1;14 (10): 510-3 .
[23] Jurysta C, Bulur N, Oguzhan B, Satman I, Yilmaz TM, Malaisse WJ, Sener A. Journal Biomed and Biotech 2009. [24] Marchetti, R. Giannarelli, A. Masoni, P. Cecchetti, A. Di Carlo, and R. Navalesi, “Salivary immunoreactive insulin concentrations are related to plasma free-insulin levels in insulintreated diabetic patients,” Diabete et Metabolisme. 1990, 16(1), 16–20. [25] C. Carda, N. Mosquera-LIoreda, L. Salom et al., “Structeral and functional salivary disorders in type 2 diabetic patients,” Medicina Oral, Patologia Oral Y Cirugia Bucal.2006, 11( 4): E309–E314. [26] Bostrom, H. F. D’Elia, U. L. F. Dahlgren et al., “Salivary ¨ resistin reflects local inflammation in Sjogren’s syndrome,” ¨ Journal of Rheumatology. 2008 , 35( 10), : 2005–2011. [27] Natheer H Al-Rawi. Oxidative stress, antioxidant status and lipid profile in the saliva of type 2 diabetics Diabetes & Vascular Disease Research. Diabetes & Vascular Disease Research 2011 ,8(1) 22–28. [28] Hegde A, Shenoy R, D’Mello P, Smitha A, Tintu A, Manjrekar P. Alternative markers of glycemic status in diabetes mellitus. Biomedical Research. 2010; 21:252-6.
[29] Simranjit Singh, Venkatapathy Ramesh, Nirima Oza, Pennagaram Dhanasekaran Balamurali, Karthikshree Vishnu Prashad, Premalatha Balakrishnan. Evaluation of serum and salivary lipid profile: A correlative study.: 2014 : 18 : 1 : 4-8. [30] Al-Rawi NH. Salivary lipid peroxidation and lipid profile levels in patients with recent ischemic stroke. Journal International Dental Medicine Research. 2010;3:57-64. [31] Al-Rawi NH. Oxidative stress, antioxidant status and lipid profile in the saliva of type 2 diabetics. Diabetes Vascular Diseases Research. 2011;8:22-8. [PUBMED]