Histopathological Effects of Supercypermethrin in Liver of Albino rats
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Abstract
Histopathological alterations histochemistry and Biochemical parameters were used to assess the toxicity of the commercial pesticide (cypermethrin) on the liver tissue of male albino rats. 48 rats were used in this study. Each set of six rats was separated into four groups in the acute experiment. The control group was subcutaneously injected with distilled water, while the other three were injected subcutaneously with the insecticide at different concentrations (0.050, 0.025, 0.10). At these different concentrations, acute toxicity was assessed. A)er 24 hours, the mortality rate and poisoning signs increased with the increase in the concentration of the pesticide. As for the subacute toxicity experiment, 4 groups were used in this experiment with 6 animals in each. a control group injected with distilled water only, and another group injected with 0.025 as a single daily dose for 10, 20, and 30 days, respectively. This pesticide In the three separate times, caused some histopathological and biochemical changes in the treated groups in liver tissues and some biochemical changes in liver function were recorded, including Alanine Transaminase(ALT), Aspartate Transaminase (AST), and the levels of protein were measured in the serum. The researchers determined that cypermethrin has acute and subacute toxic effects, which manifested as alterations in serum enzymes and histopathological abnormalities in liver tissue.
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