Estimation of vitamin D status and calcium level among pregnant women in Tikrit city: case control study
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Abstract
The demand for calcium and vitamin D rises during pregnancy, increasing the chance of hypocalcemia and vitamin D deficiency. Hypocalcemia may be associated with pregnancy-related complications. This study thus sought to ascertain the frequency of hypocalcemia and vitamin D insufficiency in pregnant women seeking secondary care, as well as to explore the possible associations between these disorders and pregnancy outcomes.
Subjects, Materials and method: This study was conducted without the use of vitamin D supplements in the first, second, and third trimesters at gestational ages more than 40 weeks, even before the convenience sample number 36 became pregnant. Control groups for Case number 10 non pregnant women. The age of cases and control women in range from 20-35years. Using the Roche Cobas e411 immunoassay device, we calculated the serum concentrations of calcium and vitamin D. The study carried out between December 2023 and February 2024 in Tikrit Teaching Hospital.
Results: A total of 36 pregnant women were enrolled in the study Mean (SD) serum Vitamin D level was 17.9±0.12mg/dl pregnant women with First trimester, 11.8± 0.18mg/dl pregnant women with second trimester and 10.5 ± 0.20mg/dl pregnant women with third trimester compared with control groups 44.4 ± 0.40 (p-value = <0.001). As well as Mean (SD) serum calcium level was (7.9±0.10, 8.2± 0.18, 7.5 ± 0.20 mg/dl) pregnant women with First, second and third trimester respectively, compared with control groups 8.4 ± 0.40 (p-value = 0.06).
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References
[0] Meza-Meza, M. R; Ruiz-Ballesteros, A. I; and de la Cruz-Mosso, U (2020). Functional effects of vitamin D: From nutrient to immunomodulator. Critical Reviews in Food Science and Nutrition, 62(11), 3042–3062. https://doi.org/10.1080/10408398.2020.1862 [2] Acar, S., & Özkan, B. (2021). Vitamin D metabolism. Vitamin D, 2021, 1-23.
[3] Saponaro F, Saba A, Zucchi R. (2020). An Update on Vitamin D Metabolism. Int J Mol Sci. 8;21(18):6573. doi: 10.3390/ijms21186573. [4] Martinelli RP, et al. (2023). Vitamin D, Cellular Senescence and Chronic Kidney Diseases: What Is Missing in the Equation? Nutrients. 10;15(6):1349. doi: 10.3390/nu15061349. [5] Weinert LS, Silveiro SP. (2015). Maternal-fetal impact of vitamin D deficiency: a critical review. Matern Child Health J.;19(1):94-101. doi: 10.1007/s10995-014-1499-7. [6] Principi N, Bianchini S, Baggi E, Esposito S. (2013). Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant. Eur J Nutr.;52(3):859-67. doi: 10.1007/s00394-012-0476-4. [7] Lau, F. H., et al. (2020). Vitamin D insufficiency is prevalent in severe COVID-19. MedRxiv, 2020-04.
[8] Al-Faris NA (2016). High Prevalence of Vitamin D Deficiency among Pregnant Saudi Women. Nutrients. 4;8(2):77. doi: 10.3390/nu8020077. [9] Shima Raskh (2020). The Importance and Role of Calcium on the Growth and Development of Children and Its Complications. International Journal for Research in Applied Sciences and Biotechnology,7(6),162–167. Retrievedfrom:https://www.ijrasb.com/index.php/ijrasb/article/view/316. [10] Poon LC, (2019). The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. 145 Suppl 1(Suppl 1):1-33. doi: 10.1002/ijgo.12802. [11] Ali, Ali Adeeb Hussein (2023). "Overview of the vital roles of macro minerals in the human body." Journal of Trace Elements and Minerals. Volume 4, June 2023. https://doi.org/10.1016/j.jtemin.2023.100076 [12] World Health Organisation (2013) Guideline: calcium supplementation in pregnant women. Geneva, World Health Organization http://apps.who.int/iris/bitstream/10665/85120/1/9789241505376_eng.pdf. Assessed 6 Jun 2016. [13] Areco VA, Kohan R, Talamoni G, Tolosa de Talamoni NG, Peralta López ME (2020). Intestinal Ca2+ absorption revisited: A molecular and clinical approach. World J Gastroenterol. 28;26(24):3344-3364. doi: 10.3748/wjg.v26.i24.3344. PMID: 32655262; PMCID: PMC7327788.Jun 2020. [Google Scholar] [CrossRef]. [14] Hofmeyr GJ, Lawrie TA, Atallah ÁN, Torloni MR (2018). Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 1;10(10):CD001059. doi: 10.1002/14651858.CD001059. [15] Sofihussein HQ. (2023). Prevalence of Vitamin D Deficiency among Pregnant Women in Sulaimaneyah City-Iraq. UHD J SCI TECH [Internet]. 2 [cited 2024 Jul. 13];7(1):1-7. Available from: https://journals.uhd.edu.iq/index.php/uhdjst/article/view/1057. [16] Sepandi M, Esmailzadeh S, Hosseini MS, Hashemi SR, Abbaszadeh S, Alimohamadi Y, Taghdir M (2020). Prevalence of Vitamin D Deficiency Among Iranian Pregnant Women. Nutrition and Dietary Supplements.;12:97-102. https://doi.org/10.2147/NDS.S261229 [17] Zahra Ahmed Al Rebh1, Ishtyak Ahmad abbas al habeeb1, Ola Abbas Abdullah Alqudaihi1, Tharwat Abdullah Almanasef1,
27et al (2018). A STUDY OF VITAMIN D DEFICIENCY IN PREGNANT WOMEN ATTENDING SOME HEALTH LABORATORIES IN THE EASTERN PROVINCE OF SAUDI ARABIA. Journal of Cardiovascular Disease Research. ISSN:0975 -3583,0976-2833. VOL09, ISSUE 04. [18] Raymond-Lezman JR, Riskin SI (2023). Benefits and Risks of Sun Exposure to Maintain Adequate Vitamin D Levels. Cureus. 5;15(5): e38578. doi:10.7759/cureus.38578. [19] Shams, S. (2020). Why wearing the burqa is on the rise in South Asia? DW. 2016 Aug 24; World (Asia).
[20] M. Al-Zoughool, A. AlShehri, A. Alqarni, A. Alarfaj and W. Tamimi (2015). Vitamin D status of patients visiting health care centers in the coastal and Inland Cities of Saudi Arabia. Journal of Public Health and Development Series, vol. 1, pp. 14-21. [21] Tuffaha M, et al. (2013). Deficiencies Under Plenty of Sun: Vitamin D Status among Adults in the Kingdom of Saudi Arabia. N Am J Med Sci. 7(10):467-75. doi: 10.4103/1947-2714.168675. [22] Ferrillo, Martina, et al, (2021). "Periodontal disease and vitamin D deficiency in pregnant women: Which correlation with preterm and low-weight birth? " Journal of clinical medicine. 10(19): 4578. Published online 2021 Oct 2. doi: 10.3390/jcm10194578 [23] Gupta A, Kant S, Pandav CS, Gupta SK, Rai SK, Misra P. (2020). Dietary Calcium Intake, Serum Calcium Level, and their Association with Preeclampsia in Rural North India. Indian J Community Med.; 41(3):223-7.doi:10.4103/0970-0218.183591. [24] Javali, Mehendi K. (). Urine Calcium to Creatinine Ratio for Early Prediction of Hypertensive Disorders of Pregnancy: A Prospective Study. MS thesis. Rajiv Gandhi University of Health Sciences (India), 30581623. [25] Wang H, Hua X, Yao N, Zhang N, Wang J, Anderson R and Sun X, (2022). The Urban-Rural Disparities and Associated Factors of Health Care Utilization Among Cancer Patients in China. Front. Public Health 10:842837. doi: 10.3389/fpubh.2022.842837