Effect of Feeding with Spirulina and Folic Acid on Some Biochemical Parameters and Histological of Laboratory Rats (Albino Rats) with Induced Anemia
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Abstract
The current study aims to evaluate the preventive effects of extracts of spirulina and folic acid in treating phenylhydrazone-induced anemia and to study some biochemical and histological alterations on blood parameters, blood lipid profile, The liver and renal functioning has been used and divided into five groups of 5 animals per group at random in plastic cages. The groups were as follows. The first group was the health control group fed the standard diet. The second group was the anemia-induced group, which was injected subcutaneously with Phenylhydrazine (PHZ) (20 mg/kg body weight for 48 hours). The third group received spirulina extract at a dosage of (100 mg/ml). The fourth group received folic acid extract at a dosage of (40 mg/ml). The fifth group received extracts of spirulina and folic acid at a combined concentration of (20 mg/ml) of folic acid and (50 mg/ml) of spirulina. The dose was administered given orally. The study found that PHZ) C6H5NHNH2(injection led to a substantial decrease (P ≤ 0.05) compared to the healthy control group in liver enzymes ALT, AST, and affected the blood lipid profile, as the values of total TC, TG, LDL, and VLDL levels all rose, but HDL levels decreased as compared to the values in the healthy control group. Dosing the rats previously injected with PHZ with spirulina and folic acid resulted in a beneficial effect and improvement in liver enzymes, as the values of ALT and AST reduced while the blood lipid profile improved.
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