Histological effect of isoniazid drug in the kidney and liver tissues of albino mice Mus Musuclus
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Abstract
The aim of this study is to investigate the histopathological changes induced by the anti-tuberculosis drug (isoniazid) in the kidney and liver tissues of white male mice Mus Musculus. 25 mice were distributed into five groups that included a control group, a therapeutic dose group of 0.625 mg, a group of 1.25 mg toxic group and a dose group The semi-lethal (LD50) is 80 mg, and the lethal dose LD range is 150 mg.
Oral administration of isoniazid led to pathological changes. In the kidneys, the tissue lesions were represented by the occurrence of necrosis in the cells of the urinary tubules in some areas, and the infiltration of inflammatory cells clearly, and the desquamation of some cells of the urinary tubules, and the swelling of some cells, which led to a narrowing in the lumen of the urinary tubules. The nuclei are necrotic and disintegrated. The glomerulus was some areas enlarged and some areas atrophic.
As of the liver, it was represented by the occurrence of necrosis, hemorrhage and congestion, infiltration of inflammatory cell, thickening of the plasma membrane, widening of the sinusoids some araes and narrowing them at other times.
Conclusion
The administration of isoniazid led to pathological changes in the kidneys, including necrosis, infiltration of inflammatory cell, glomerulosclerosis, nucleoli, as well as changes in the liver, including hemorrhage, rupture of the vein wall, and hemolysis of blood cells
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