Sciatic Nerve Regeneration Using Collagen Tubes and Acellular Nerve Transplants in Rabbits (A comparative study)
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Abstract
The present study was conducted to evaluate and compare on anatomical bases between the different types of nerve graft, autograft, collagen tubes (natural polymers), and acellular epineurial nerve sheaths (biological conduits), which included acellular rabbit nerve graft and acellular rat nerve graft.
Fourty local breaded rabbits were used and divided into four groups, each of ten rabbits. Then each group was subdivided again into two subgroups according to time of scarifying, which was after 45 days and 3 months post operation.
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References
[1] Snell, RS. Clinical neuroanatomy, 7th ed. Lippincott Williams and Wilkins; 2010. P:13.
[2] Sunderland, SS. Nerve injuries and their repair: a critical appraisal. New York: Churchill Livingstone. 1991. P:33.
[3] Sunderland, SS. Factors influencing the course of regeneration and the quality of the recovery after nerve suture. Brain. 1952; 75:19.
[4] Raffe, MR. principles of nerve repair: biology of nerve repair and regeneration. In: Newton, CD; Nunmarker, DM. Textbook of small animal. Orthopedic. 1985: p504-545.
[5] Mariann, S; Goran, L; and Martin, K. regeneration of the rat sciatic nerve into allografts made a cellular through chemical extraction. Brain. Res. 1998. 795: 44-54.
[6] Bryan, JP; Gordon, T; Loverde, JR; Kochar, AS; Mackinnon, AS; Cullen, DK. Biomedical engineering strategies for peripheral nerve repair: surgical application; state of the art and future challenges. Critical reviews iin biomedical engineering. 2011; 39(2): 81-124.
[7] Ijkema, P; Meek, MF; and Gramsbergen, A. transection of the sciatic nerve and reinnervation in adult rats: muscle and endplates morphology. Equine. Vet. J. 2011. 33:41-50.
[8] Saxon, S; Carnol, P. mechanism of axon degeneration from development to disease. Prog. Neurobiol. 2007. 83: 174-191.
[9] Elke, Y; Anje, C; Bob, A; Sofie, G; Guillauma, L; Leonardo, AS; Van ginderachter, JOA; Sofie, J. acute injury in the peripheral nervous system triggers an alternative macrophages response. J. neuro-inflammation. 2012. 9:176-195.
[10] Keterina, A; Wei, MY; Pinar, A; Sidney, S. fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. J. cell. Boil. 2002; 33:861-875.
[11] Keiseir, BC; Seifert, T; Giovannoni, G; Hartung, HP. Matrix metalloproteinases in inflammatory demyelination: targets for treatment. Neurology. 1999; 53:20-25.
[12] Colin, W; Donoff, RB. Nerve regeneration through collagen tubes. J. dent.. res. 1984; 63:987-933.
[13] Guo, Ly; Zhitao, J; Haiying, Z; Zhang, Xy; Xiaojie, T. immunological rejection of a cellular heterogenous nerve transplant for bridging the sciatic nerve in rats. Neurol. Regen. Res. 2010; 5.
[14] Gerburg, K; Florian, P; Gerlad, W; Hisham, F. bridging extra-large defects of peripheral nerves: possibilities and limitations of alternative biological grafts from a cellular muscle and Schwann cells. Tissue. Engine. 2005. 11:1004-1015.