New 3- hydrazonoindolin-2-one Cd(II) complexes with amino pyridine ligands, Synthesis, Characterization and biological activity evaluation
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Abstract
This research includes synthesis and characterization of some of Cd(II) complexes with (3-hydrazonoindolin-2-one)(HZI) ligand and amino pyridine ligands.
Treatment equialmolar of CdCl2.2.5H2O and (HZI) ligand with two moles of n-aminopyridine (n-amp) (n:2,3,4) ligands afford a tetrahedral complexes of the type [Cd(HZI)(n-amp)2]Cl2, where (HZI) ligand behaves as a bidentate chelating fashion through the N atom of azomethine group and O atom of carbonyl group. Whereas the (n-amp)(n: 2,3,4) was bonded monodentate mode through the N atom of heterocyclic ring.
The prepared complexes have been characterized by molar conductivity, elemental analysis, infrared spectra and 1H-NMR and 13C-NMR spectra.
Also the evaluation of biological activity of the prepared complexes against two types of gram positive bacteria (Staphylococcus Epidermidis and Staphylococcus aureus) and (Citrobacer Freundii) and gram negative, all prepared complexes showed activity against Staphylococcus aureus more than amikacin, while the [Cd(HZI)(3-amp)2]Cl2 complex showed high activity against Staphylococcus Epidermidis and Citrobacter freundii more than another prepared complexes
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