Using Serum Interleukin-18 (IL-18) as a Biomarker of Chronic Kidney Failure and its relationship with Prolactin Level
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Abstract
Kidney failure usually occurs as a result of lacking the normal functions of kidney as either partly or completely. In the last years, it was announced that the Interleukin-18 has received significant interest as inflame marker. IL-18 also strongly associated with renal function, and was a powerful predictive marker of renal function turbulence.
Aims: The main aim of this research is to study the relation of prolactin levels with chronic kidney failure, and to assess the relationship between serum Interleukin-18 and chronic kidney failure. Methods: The study was carried out in Tikrit Teaching Hospital from 1st of March Until the 15th of July 2019, and included 150 blood samples from patients suffering from chronic kidney failure, and 50 samples from healthy individuals as control group. Results: The study revealed the highest rate of prolactin level 58% was found in female and 23% was found in male. While in control group, the lowest level of prolactin 7% was found in male and 11% was found in female. The present study showed the highly significant relation (P<0.01) between IL-18 level and CKF. IL-18 was increased in patients with renal failure comparing with the control group (66.5±49.6 vs. 49.5±27).
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