Interstop [Dioraleze] Drug-induced hepatotoxicity and Liver Injury In Rats
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Abstract
Interstop (Also known as Dioraleze) was the focus of this research paper to elaborate and find out the effect of Interstop administration on Hepatocytes in Rats.
Rats from both sexes were randomly distributed into three main groups as follows:
Group 1 (Control): Orally given distilled water daily for three weeks.
Group 2 (Treatment): Orally given 1mg/kg body weight Interstop daily for three weeks.
Group 3 (Overdose): orally given 2.5mg/kg body weight Interstop daily for three weeks.
At the end of the experiment, rats were dissected and the liver was obtained under aseptic technique for laboratory study.
Drug-induced liver disease is usually a result of metabolites that could affect the cell and tissue biochemistry directly or result in an immune response which was found in this study as the occurrence of several Vascular Sacs directly attached to the liver in all rats present in group 2 and 3. The sac ranged in size from 0.5 cm-1 cm compared to control that lacked the presence of any vascular sac.
Liver in both treatment groups showed several abnormalities after treatment compared to Group 1 which includes Karyolysis, pyknosis and Karyohexsis. Atrophy and necrosis in addition to degeneration of hepatocytes was seen.
In conclusion, Interstop has shown remarkable damaging effects on the Liver, especially when used without medical awareness and at higher doses than recommended, hence, leading to Hepatocyte abnormalities increasing organs malfunction and performance deficiency after long time of treatment.
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