Detection of infection by rubella and cytomegalovirus among women exposed to abortion in Ninavah province
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Abstract
The study aims to correlate infection with rubella, cytomegalovirus and abortion at different age groups.
Blood samples were collected through the period between beginning of February to the end of September 2017, one hundred and twenty-seven women exposed to abortion and thirty apparently health controls. Serum samples were tested for IgM and IgG antibodies for rubella and cytomegalovirus.
The results showed that CMV was the most common infection with high level of IgM antibodies (15.7%) and IgG (12.5%), only 0.7% of the cases gave positive results for rubella IgM, and 6.2% had rubella IgG while the control group only 6.6% had CMV IgM, and 3.3% had CMV IgG antibody. All the age groups did not show infection with rubella except age 25-31 years as 2.1% and 8.5% had IgM and IgG respectively. The highest rate of infection with CMV was at age group 25-31 years (21.2%) then age group 18-24 years (13.7%). Most of the patients experienced two abortions were reported at age group 25-31 years, 1.5% and 4.7% of CMV infected patient experienced 3 and 2 respectively while 1.5% of rubella infected patients had only one abortion, 18.1% of the patients with CMV experienced 2 abortions had cut off >1.25. Hundred % of the patients with rubella had cut off value of > 1.25 experienced one abortions.
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References
[1] Anselem O, Tsatsaris V, Lopez E, Krivine A, Le Ray C, et al. (2011) Measles and pregnancy. Presse Med. 40(11): 1001–7 [2] Barrabeig, I., Torner, N., Martínez, A., Carmona, G., Ciruela, P., Batalla, J. & Group of Catalonia, T. R. S. (2013). Results of the rubella elimination program in Catalonia (Spain), 2002–2011. Human vaccines & immunotherapeutics 9(3): 642-648.
[3] Ramana B, Murty D, Naidu KV, Reddy BK. Seroprevalance of rubella in women with bad obstetric history in Tirupati of Andhra Pradesh state of India. Annals of Tropical Medicine and Public Health. 2012;5(5):471. [4] Olajide, O. M., Aminu, M., Randawa, A. J., & Adejo, D. S. (2015). Seroprevalence of rubella-specific IgM and IgG antibodies among pregnant women seen in a tertiary hospital in Nigeria. International journal of women's health, 7: 75.
[5] Plotkin SA and Orenstein (2004). Vaccines. 4th edition. Philadelphia: WB Saunders Company, 19, 20 and 26. [6] Neil, K. K. (2013). Congenital rubella A service of the U.S. National Library of Medicine National Institutes of Health 14(5):306-315 [7] De Paschale, M., Agrappi, C., Manco, M. T., Paganini, A., & Clerici, P. (2009). Incidence and risk of cytomegalovirus infection during pregnancy in an urban area of Northern Italy. Infectious diseases in obstetrics and gynecology 2009.
[8] Soderberg - Naucl´er C. (2006). Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J. Intern Med 259: 219–246.
[9] Taylor-Wiedeman J, Sissons JG, Borysiewicz LK, Sinclair JH. (1991). Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J Gen Virol 72(Pt 9): 2059–2064 [10] Kenneson, A., & Cannon, M. J. (2007). Review and meta‐analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Reviews in medical virology 17(4): 253-276.
[11] Boppana SB, Ross SA, Fowler KB. (2013). Congenital cytomegalovirus infection: clinical outcome. Clin Infect Dis 57: S178 – 81 [12] Nirmal, K., Saha, R., Ramachandran, V. G., & Khan, A. M. (2017). TORCH infection in antenatal women: A 5-year hospital-based study. Eastern Journal of Medical Sciences, 2(4). [13] Kishore, J., Misra, R., Paisal, A., & Pradeep, Y. (2011). Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy. J Infect Dev Ctries, 5(12): 868-873. [14] Alshami, Z. M. A., Ridha, M. A. A., & Nazar, A. M. A. (2016) Investigation of Actual Rate of Primary and Mixed Infections with some TORCH Agents among Iraqi Gravidas with History of Recurrent Abortions. International Journal of Science and Research (IJSR). 5(9): 691-696 [15] Munro, S. C., Hall, B., Whybin, L. R., Leader, L., Robertson, P., Maine, G. T., & Rawlinson, W. D. (2005). Diagnosis of and screening for cytomegalovirus infection in pregnant women. Journal of clinical microbiology, 43(9): 4713-4718. [16] Tiwari, S., Arora, B. S., & Diwan, R. (2016). TORCH IgM seroprevalence in women with abortions as adverse reproductive outcome in current pregnancy. International Journal of Research in Medical Sciences, 4(3), 784-788. [17] Sherkat, R., Meidani, M., Zarabian, H., Rezaei, A., & Gholamrezaei, A. (2014). Seropositivity of cytomegalovirus in patients with recurrent pregnancy loss. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19(1): S22. [18] Hamdan HZ, Abdelbagi I, Nasser NM, Adam I (2011). Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan. Virol J. 8: 217-220 [19] Mohammed, L. M. (2015). Prevalence of rubella virus in pregnant women in Kirkuk City-Iraq. Kirkuk University Journal / Scientific Studies (KUJSS), 10(1): 47-57. [20] Lulandala, L., Mirambo, M. M., Matovelo, D., Gumodoka, B., & Mshana, S. E. (2017). Acute Rubella Virus Infection among Women with Spontaneous Abortion in Mwanza City, Tanzania. Journal of clinical and diagnostic research: JCDR, 11(3): QC25.