Estimation of the level of homocysteine and vitamin B12 in serum of patients with hypothyroidism
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Abstract
In this study, homocysteine and vitamin B12 levels were measured in patients with hypothyroidism in Salahdin Governorate. The study was conducted at the Tigris Educational Hospital in Tikrit. Blood samples were taken from patients with hypothyroidism (40 cases) with thyroid deficiency and 30 healthy (non-infected) subjects. Their ages ranged between 25-35 years. The study found that there was a significant increase p<0.05 in the homocysteine level compared to the healthy Individuals as control group. The study also showed a significant decrease in the level of vitamin B12 for patients p <0.05 compared to healthy individuals .
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References
1- Raven, P.H.; Johnson, G.B.; Loso, J.B. and Singer, S.R. (2004). Biology. 7th edn MC. Graw Hill: 1055 pp.
2- Boron, W.F. and Boulpaep, E.L. (2003). Medical Physiology .Saunders.
3- Yalcin, B. and Ozan, H. (2006). Detaliled investigation of the relationship between inferior Larygeal nerve including laryngeal branches and ligament of Beery. Jour. Of American Coll. Of Surg. 202 (2): 291-6.
4- Hall, J. and Guyton (2015). Textbook of medical physiology 12th edn. Philadelphia, USA; Elsevier: saunders. Ch. 76: 907-912 pp.
5- Ghant WRE skin BA. Low DA Kill LP. (1993). can J. surg.
6- Miyaki, K. (2010). Genetic polymorphisms in homocysteine metabolism and response to folate Intake: A Comprehensive strategy to Elucidate Useful Genetic information. J Epidemiol, 20(4): 266-270.
7- Skovby, F.; Gaustadnes, M.; and Mudd, S. H. (2010). A revisit to the natural history of homocystinuria due to cystathionine β-synthase deficiency. Molecular genetics and metabolism, 99(1): 1-3.
8- Zahra, E. (2010). M.sc., Rajab - Ali s. Int J Reprod Bio Med, 14(8): 495-500, (2016), "PCOS women show significantly higher homocystiene level , independent to glucose and E2 Level".
9- Nadia, A.S. and Ommeed M. (2015). Tikrit University, chemistry Department, salahaddin, Iraq. "Determination of the concentration level of Homocystiene in the serum of patients with Myocardial and Type II Diabetes in salahaddin province".
-01 آل فليح، خولة أحمد ) 2117 ( "مدخل الى الكيمياء الحياتية" دار
الكتب للطباعة والنشر، الطبعة الثانية، جامعة الموصل ص 185-186 ص – 082 - 084 .
11- Robert, C. and Brown, D.L. (2003). Vitamin B12 deficiency. Am. Fam., 67(5): 979-986.
12- Butler, C.C. et al. (2006). Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Family practice, 23(3): 279-285.
-01 أحمد، طارق يونس، الهلالي، لؤي عبد علي ) 2010 (. "الكيمياء
الحياتية" الجزء الأول، و ا زرة التعليم العالي والبحث العلمي جامعة –
الموصل دار ابن الايثر للطباعة والنشر، ص – 217 - 219 .
14- Joosten, E. et al. (1993). "Metabolic evidence that deficiencies of vitamin B− 12 (cobalamin), folate, and vitamin B− 6 occur commonly in elderly people." The American journal of clinical nutrition, 58(4): 468-476.
15- Robinson, Killian, et al. (1998) "Low circulating folate and vitamin B6 concentrations: risk factors for
stroke, peripheral vascular disease, and coronary artery disease." Circulation, 97(5): 437-443.
16- Seshadis, et al. (2002). N. Engl. J Med., 346: 477-483.
17- Mel, C. R. et al. (2004). N. Eng. J. Med., 350: 2042-2049.
18- AACC. (1994). Approved Methods of the Amarican As ssociation of cereal chemists, 8 thed. American.
-09 العاصي، وسن نزهان حسين علي. "تحديد التأثير الحياتي
والو ا رثي للهوموسستين على مرضى احتشاء العضلة القلبية". اطروحة
دكتو ا ره، كلية التربية جامعة تكريت - (2012)
20- De, V.S. et al. (2008). "Mild subclinical hypothyroidism in thalassaemia major: prevalence, multigated radionuclide test, clinical and laboratory long-term follow-up study." Pediatric endocrinology reviews: PER 6: 174-180.
21- Krzysztof, A. (2007) Medical University of Gdansk, "Homocysteine, foliate and cobalamin levels in hypothyroid women before and after treatment".
22- Yining, D.J. (2015). The first Affiliated Hospital, college of Medicine, Zhejiang University Hangzhou, china. "Association of homocystenie level with biopsy proven non-alcoholic fatty liver disease: ameta-analysis".
23- Maha, F.S. (2016). Clinical bio chemistry Dept., college of Medicine, University of Babylon, "Assessment of leptin levels in the different genotypes and leptin receptor genes in the women with polycystic ovary syndrome and diabetes mellitus stype 2 in Iraq population".
24- Catargi, B. et al. (1999). Homocysteine, hypothyroidism, and effect of thyroid hormone replacement. Thyroid, 9(12): 1163-1166.
25- Lisa, C.U. and Edwina, J.M.D. (2016). B. Sc. college of pharmacy and Health sciences, Campbell University, Busies, creek. "Role of statin Drugs for polycystic ovary syndrome".
26- Motham, A.; Ali, M. and Mohammed, A. (2014). (Homocysteine level in Reation to thyroid function tests in Hypothyroid Patients). Asian J. of Medical and pharma R., 4(2): 101-106.
27- Nadia, A.S. and Wasan, N.H. (2013). Department of chemistry, college of Education, Tikrit University Iraq. "Study plasma Homocysteine level in Alzheimer's Disease AnditsRelation ship with the folic acid and vitamin B12 in Alshamaiah Baghdad Hospital".
28- Assistant professor, Govt. (2017). Stanley Medical College, Chennai, professor, Dept. of Biochemistry, Madras Medical, Chennai "Association of total plasma homocysteine levels in hypothyroid in dividuals".
29- De J.J. et al. (2010). "Long term treatment with metformin in patients with type 2 diabetes and risk of
vitamin B-12 deficiency: randomised placebo controlled trial." Bmj, 340: c2181.
30- Snow C.F. (1999). Laboratory diagnosis of vitamin B12 deficiency. Arch Inter Medicine, 159: 1289-98.1 w.
31- Kara, A.M. (2017). University of Utah school of medicine "Folate, homocysteine and the ovarian cycle among healthy regularly menstrnating women".