Comparative study of Vitamin D levels in diabetic and non- diabetic women and its correlation with age and seasonal variation
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Abstract
Background vitamin D has characteristics features of a hormone, and accordingly vitamin D is a pro-hormone, rather than a true vitamin. Active form of vitamin D is binding to vitamin D receptors (VDR) then started its main action inside the body.
This study is aimed to compare concentration of vit. D in a patients with diabetes mellitus, and healthy Iraqi women and its correlation with seasonal variation, and age.
Subjects and methods This study was conducted in the first of August 2017 till the first of April 2018, at the outpatient unit in especial private hospital at karbalaa city in the south of Iraq. 163 women have been enrolled in present study. The sample was divided into 3 groups in both diabetic and non-diabetic subjects.
Results the distribution of subjects in this study, 163 persons participated as a sample in a present research; 82 subjects are normal healthy women as controls, while 51 women suffering from non-insulin dependent diabetic mellitus, (T2DM), and 30 pregnant women suffering from gestational DM, (GDM). Stander deviation and mean of Vit. D levels in a non-insulin dependent diabetes mellitus and normal healthy women. There is significant reduction in the levels of vit.D that measured by using sera of women patients suffering from T2DM, (12.97 ± 8.9) as compared with control subjects, (18.95 ± 7.1).
Conclusions the present study conclude that, the measurement of vit.D are significantly reduced when measured in women patients with non-insulin dependent diabetes sera, as compare to healthy subjects and also reduced in the sera of women patients suffering from GDM, as compared with control subjects.
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References
[1] A.V. Scwartz, et al. (2011). Cummings Older women with diabetes have an increased risk of fracture: a prospective study. J Clin. Endocrinol Metab, 86: 32-38.
[2] Al-Horani H, Wael AD, Eyad M, et al .(2016). Nationality, gender, age, and body mass index influences on vitamin D concentration among elderly patients and young Iraqi and Jordanian in Jordan. Biochem Res Int. Available from:
https://doi.org/10.1155/2016/8920503.12. Gallagher JC. Vitamin.
[3] Golbahar J. et al. (2014). Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study. Public health nutrition. Apr 1;17(04) :732-8..
[4] Calvo MS, Whiting SJ, Barton CN.(2005). Vitamin D intake: a global perspective of current status. J. Nutr , 135(2), 310–316.
[5] Al-Timimi DJ, Ali AF.(2013). Serum 25(OH) D in diabetes mellitus type 2: relation to glycaemic control. J Clin Diagn Res, 7(12):2686–88 .
[6] Kostoglou - Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. (2013). Vitamin D and glycaemic control in diabetes mellitus type 2. Therapeutic Advances in Endocrinology and Metabolism, 4(4):122–128
[7] Jain, R. et al .( 2012). Association of vitamin D receptor gene polymorphisms with insulin resistance and response to vitamin D. Metabolism, 61 (3), 293–301.
[8] Hartling, L.et al.(2012). Screening and diagnosing gestational diabetes mellitus. 210 pp. 1–327.
[9] Amit V, Vadana K, Neeraj K, Preeti K. (2014). Vitamin D and Diabetes: A New Horizon, Acta Medica International,1(2): Jul – Dec,136-168.
[10] Triunfo S., Lanzone A., Lindqvist P. G.(2017). Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus. Journal of Endocrinological Investigation. 40(10):1049–1059. doi: [10]1007/s40618-017-0696-9.
[11] Aghajafari, F. et al .(2013). Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ, 346: f1169.
[12] Djalali, M. et al.(2013). Vitamin D Status of Type 2 Diabetic Patients Compared with Healthy Subjects in the Islamic Republic of Iran. Journal of Eastern Mediterranean Health, (9): 1-6.
[13] Nasri. H, Behrad M. S, Maghsoudi R. A.(2014). Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial. Journal of Renal Injury Prevention, 3(1): 31-34.
[14] Taheri Ehsaneh, Saedisomeolia Ahmad, Djalali Mahmoud.(2012). The relationship between serum 25-hydroxy vitamin D concentration and obesity in type 2 diabetic patients and healthy subjects. Journal of Diabetes & Metabolic Disorders, 11:16-23.
[15] Abed El-Raoof D. M. (2014).Serum Vitamin D Level in Type 2 Diabetic Patients from. M.Sc. thesis, Gaza university, Gaza Strip, Plastine:
16. Xiaoning Yan.( 2014). Vitamin D status and its relation to metabolic syndrome. M.sc thesis submitted to Massey university, New Zealand.
[17] Battista, M. C. et al. (2014). Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetalogica, 51(4): 609-616. Doi: 10.1007/s00592-014-0564-4.
[18] Wagner, R. et al. (2013). Family history of diabetes is associated with higher risk for prediabetes: a multicentre analysis from the German Center for Diabetes Research. Diabetologia, 56(10): 2176-2180.
[19] Wolden-Kirk, H.; Overbergh, L.; Christesen, H.T.; Brusgaard, K.; Mathieu, C. (2011). Vitamin D and diabetes: Its importance for beta cell and immune function. Mol. Cell. Endocrinol, 347:106–120.
[20] Hummel, D. et al.(2014). The vitamin D system is deregulated in pancreatic diseases. The Journal of
Steroid Biochemistry and Molecular Biology, 144 (B): 402–409.
[21] De-Regil L. M., Palacios C., Lombardo L. K., Pena-Rosas J. P.(2016). Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews. (1, article CD008873) doi: 10.1002/14651858.CD008873.
[22] Lee, B.K. Park, S.M. Kim, Y.H.(2012). Age and gender specific associations between low serum 25-hydroxyvitamin D level and type 2 diabetes in the Korean general population: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data. Asian Pac Journal Clinical Nutrition, 21(4):536-546.
[23] Gulseth H. L., Gjelstad I. M., Birkeland K. I., Drevon C. A.(2013). Vitamin D and the metabolic syndrome. Current Vascular Pharmacology, 11(6): 968–984. doi:
10.2174/15701611113119990169 .
[24] Angueira AR, Ludvik AE, Reddy TE, Wicksteed B, Lowe WL, Jr., Layden BT.(2015). New insights into gestational glucose metabolism: lessons learned from 21st century approaches. Diabetes, 64(2):327-34.
[25] Eggemoen A. R., Jenum A. K., Mdala I., Knutsen K. V., Lagerlov P., Sletner L.(2017). Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. British Journal of Nutrition, 117(07):985–993. doi: 10.1017/s000711451700068x.
[26] Kramer, C. K. et al.(2014). Vitamin D and parathyroid hormone status in pregnancy: effect on insulin sensitivity, β-cell function, and gestational diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 99(12):4506–4513. doi: 10.1210/jc.2014-2341. .
[27] O'Brien E. C. et al .(2017). McAuliffe F. M. Season and vitamin D status are independently associated with glucose homeostasis in pregnancy. Nutrition & Metabolism. 14(1):p. 50. doi:
10.1186/s12986-017-0203-5. .
[28] McLeod D. S. et al .(2012). Associations of serum vitamin D concentrations with obstetric glucose metabolism in a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. Diabetic Medicine, 29(8):e199–e204.
[29] Bo S, Menato G, Lezo A, et al.(2011).Dietary fat and gestational hyperglycaemia. Diabetologia, 44: 972–8.
[30] Haidari, F; Jalali, MJ., Shahbazian, N.(2016). Comparison of Serum Levels of Vitamin D and Inflammatory Markers Between Women With Gestational Diabetes Mellitus and Healthy Pregnant Control. Journal of Family and Reproductive Health. 10(1): 1-8. [31] Pittas, A.G et al. (2007). The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab, 92: 2017–2029. [32] Reeder AI, Jopson JA, Gray AR.(2012). “Prescribing sunshine”: a national, cross-sectional survey of 1,089 New Zealand general practitioners regarding their sun exposure and vitamin D perceptions, and advice provided to patients. BMC Fam Pract,13:85. doi: 10.1186/1471-2296-13-85. [33] van der, R. H. Coebergh JW, de Vries E.(2013). Is prevention of cancer by sun exposure more than just the effect of vitamin D? A systematic review of epidemiological studies. Eur J Cancer. 49(6):1422–36.