A Study of the thermodynamic parameters (functions) of complexes formation of Sulfanilamid with metal ions and DL-Alanine by potentiometric method
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Abstract
The current study deals with the preparation of disulfonalmide complexes composed of the sulfanilamid drug , the salt of chromium(III) and the trisulfonalmide complexes composed of the sulfonalmide drug , the metal salt and the amino acid (alanin), as well as study in the stability constant of each complex and making a comparison between them . The obtained results show that the tricomplex stability constant is higher than the dicomplex stability constant due to the existence of the amino acid in the tricomplex which makes greater stereo structure and eventually easier interaction. Besides the thermodynamic functions in this experiment have been studed since they cause a chemical spontaneous reaction and a random arrangement in system.
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References
[1] Domagk, G. (1935) , A Contribution to the Chemotherapy of Bacterial Infections. Deutsche Medizinische Wochenschrift , 6, 250-253.
[2] Thiele-Bruhn, S.J. (2003), Pharmaceutical Antibiotic Compounds in Soils—A Review. Journal of Plant Nutrition and Soil Science , 166, 145-167.
[3] Zani, F. and Vicini, P. (1998), Antimicrobial Activity of Some 1,2-Benzisothiazoles Having a Benzene sulfonamide Moiety. Archiv der Pharmazie , 331, 219-223.
[4] Maren, T. (1976), Relations between Structure and Biological Activity of Sulfonamides. Annual Review of Pharmacology and Toxicology, 16, 309-327.
[5] Supuran, C.T., Scozzafava, A., Jurca, B.C. and Iiies, M.A. (1998), Carbonic Anhydrase Inhibitors—Part 49: Synthesis of Substituted Ureido and Thioureido Derivatives of Aromatic/Heterocyclic Sulfonamides with Increased Affinities for Isozyme I. European Journal of Medicinal Chemistry , 33, 83-93.
[6] Rossotti, F. and Rossotti, H. (1961), The Determination of Stability Constants and Other Equilibrium Constants in Solution. 4th Edition, McGraw-Hill Book Company Inc., New York.
[7] Kirschner, S., Wei, Y., Francis, D. and Bergam, J. (1966), Anticancer and Potential Antiviral Activity of Complex Inorganic Compounds. Journal of Medicinal Chemistry , 9, 369-372.
[8] Thomas G. .2002, Medicinal Chemistry, John Wiley and Son Co. Ltd. London.
[9] Richards F.M., Wyckoff H.M., Allewel N.M. Neurosciences, Rock feller University Press New York ,1,969; 901.
[10] Sigel H, Marcel,1973, Metal Ions in Biological Systms, Dekker, Inc New York;2.
[11] Jeejeebhoy, K. N., et al. (1977). Chromium deficiency, glucose intolerance and neuropathy reversed by chromium supplementation in a patient receiving long-term total parenteral nutrition. Am. J. Clin. Nutr. 30, 531–538.
[12] Nida Iqbal, Javed Iqbal, Muhammad Imran (2009) Base, A. Schiff. synthesis, characterizon and antibacterial studies of some metal complexes of a schiff base derived from benzaldehyde and sulfonamide. J, Sci Res. [13] Varshney A., Tandon J.P. (1986) Synthesis and spectral studies of tin (IV) complexes with Schiff bases derived from sulpha drugs, J Chem Sci 97: 141- 145.
[14] Bielicka A, Bojanowska I, Wiśniewski A. 2005 ; two faces of chromium - pollutant and bioelement. Polish Journal of Environmental Studies [Internet]. 14(1):5-10.
[15] Anderson R.1981, Nutritional role of chromium. Science of The Total Environment.; 17(1):13-29.
[16] Zohdi H, Emami M, Reza H. (1981). Galvanic corrosion behavior of dental alloys. Environmental and Industrial Corrosion - Practical and Theoretical Aspects; 2012.
[17] Textbook of Biotechnology2012. McGraw-Hill Education (I).. ISBN 9780071070072.
[18] Kęstutis R, Asta, Ingrida T, Kristina K, Marytė K, Alexey Kazokaitė V, Edita Č, Elena M, Saulius G, Zigmuntas J. B. and Daumantas M. (2014). 4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases. Molecules, 19, 17356-17380.
[19] The Council of the College of Education University of Mosul.2013.
[20] Gopalan R, Ramalingam V. 2007, Concise Coordination Chemistry, Vikas Publishing House Private Ltd New Delhi;338.
[21] Underwood E.J. 1977, Trace Elements in Human and Animal Nutrition, Academic Press;4.
[22] Caumul P., Boodhoo K., Burkutally S.B., Seeruttun S., Namooya N., Ramsahye N. Joondan N. 2014, Res J Pharm Biol Chem Sci ; 5(1):494-501.
[23] Mathews, Christopher K., (2000). Biochemistry. Van Holde, K. E., Ahern, Kevin G. (3rd ed.). San Francisco, Calif.: Benjamin Cummings. ISBN 0805330666. OCLC 42290721.
[24] Yoshimura, Tohru; Nishikawa, Toru; Homma, Hiroshi (2016-08-25). D-Amino Acids: Physiology, Metabolism, and Application. Springer. ISBN 9784431560777.
[25] Daniele, P., Zerbinati, O., Zelano, V. and Ostacoli, G. (1998) Thermodynamic and Spectroscopic Study of Copper (II) – glycyl – L -histidylglycine Complexes in Aqueous Solution. Journal of the Chemical Society, Dalton Transactions, 10, 2711-2715.
[26] Amrallah, H., Abdalla, A. and El-Haty, Y. (1998) Mixed Ligand Complexes of Benzimidazole and Pyrimidine Hydroxyazo Dyes with Some Transition Metals and Glycine, DL-Alanine or DL-Leucine. Talanta, 46, 491-500.
[27] Inci, D. and Aydin, R. (2017) Potentiometric Studies on Complexation of Cu(II) Ion with Methyl/Nitro-Substituted 1,10-Phenanthrolines and Selected Amino Acids. Journal of Solution Chemistry , 46, 124-138.
[28] Shakru R, Sathish Kumar. K, Vijay Kumar Chityala and Shivraj, 2011, (Potentiometric Studies of 3-Amino-5-Methyl Isoxazole Schiff Bases and Their Metal Complexes In Solution) Department of Chemistry, Osmania University, Hyderabad-500 007(A.P.) India .
[29] Pratibha Mittala, Uma .V, *Ojha. a K.G ,2010, (Potentiometric and thermodynamic studies of schiff base hydrazine metal complexes) Department of Chemistry, Faculty of Science, Government College, Ajmer(INDIA).
[30] R.A. Khalil*, A.H. Jalil and A.Y. Abd-Alrazzak,2009, (Application of a Schiff Base Derived from Sulfanilamide as an Acid-Base Indicator) Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.
[31] Atmaram K. Mapari* and Kiran V. Mangaonkar,2011, (Mixed Ligand Complexes of Transition Metal (II) ions with N-(2-hydroxybenzylidene)-2,3-dimethylaniline as Primary Ligand and N - (2-hydroxy – 1 - naphthylidene) – 4 -chloroaniline as Secondary Ligand) Maharashtra, India..
[32] Basavaraj M. Kalshetty, R.C. Sheth, R.R. Chavan and M.B. Kalashetti, 2011, (Role of Temperature on Stability Constants of Metal Complexes in 50% (V/V) Water-Ethanol Solution) Department of Chemistry, B.L.D.E’S Comm., B.H.S. Arts and T.G.P. ScienceCollege Jamakhandi – 587302. Karnataka.
[33] Fatma S. M. Hassan.2005, (Formation of Mixed Ligand Complexes of Ni(Ii), Pd(Ii), And Pt(Ii) Involving Salicylidine – 3 – Amino - 1,2,4 - Triazole (Schiff Base ) As A Primary Ligand And Cysteine as Secondary Ligand) Chemistry Department, Faculty of Science, South Valley University, Aswan, Egypt. [34] Rana Tahseen Ali(Stability and Fluorescence Studies Number of Drug Complexes with Metal Ions Chooser) Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.
[35] Hayati Sari, Muzaffer Can, and Mustafa Macit , (2005), "Potentiometric and Theoretical Studies of Stability Constants of Glyoxime Derivatives and their Nickel, Copper, Cobalt and Zinc Complexes " , Acta Chim. Slov., Vol. 52 , pp.317–322.
[36] Abdulbaset A. Zaida, Mazahar Farooqui, D.M. Janrao , (2012) , " Study of Stability Constants of Biological Active Molecular (drug) Using Potentiometric Titeration Technique " , J. Chem. Biol. and Phys. Science " Vol.2.No.1, pp.67-81.
[37] Agwara. M.O.*, Ndifon. P.T, Ndosiri. N.B, Paboudam .A.G, Yufanyiand.D.M, Mohamadou. A,2010, (Synthesis, Characterization and Antimicrobial Activities of Cobalt (II), Copper (II) and Zinc(II) Mixed-Ligand Complexes Containing 1,10-Phenanthroline and 2,2’-Bipyridine) Department of Chemistry, University of Buea, P.O. Box 63, Buea, Cameroun.
[38] A.K.Mapari and K.V. Mangaonkar, (2011), "Stability Constants of Mixed Ligand Complexes of Transition Metal (II) Ions With N-(2-hydroxybenzylidene) - 2,3 - dimethyleaniline as Primary Ligand and N-(2-hydroxy-1-naphthylidene)-4-nitroaniline as Secondary Ligand", E-J. of Chem., Vol. 8 , No. 2 , pp. 859-862 .
[39] Susmita Bandyopadhyay and G N Mukherjee , (2003), " Fac–mer equilibria of coordinated iminodiacetate (ida2–) in ternary Cu (ida)(H–1B)– complex formation (B = imidazole, benzimidazole) in aqueous solution", Indian Acad. Sci. (Chem. Sci.), Vol. 115, No. 4, pp 249–261.
[40] Abdulbaset A. Zaida, Mazahar Farooquia,b , D. M. Janrao, (2012), " Potentiometric studies of the Zinc (II) complexes with some medicinal compounds and glycine in aqueous solution", Der Chemica Sinica, Vol.3, pp.64-70.
[41] Bushra Hina, Ghazala Hafeez Rizwani, Huma Shareef and Maryam Ahmed , (2012) , " Atomic absorption spectroscopic analysis of some Pakistani herbal medicinal products used in respiratory tract infections", Pak. J.Pharm. Sci., Vol.25, No.1, pp.247-253. [42] Mehta B, Mehta M (2006) Organic Chemistry , 2nd Edn, Prentice-Hall of India Private Limited, New Delhi, India.