Estimation the levels of interleukin 6 and tumor necrosis factor-alpha patients with diabetic type 2 in Tikrit city
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Abstract
Type 2 is the most common metabolic disorder characterized by the increased concentration of glucose in blood due to insulin resistance or relative insulin deficiency. Changes in human behavior and lifestyle over the last century have resulted in a dramatic increase in the incidence of diabetes worldwide. Interleukin 6 is pro inflammatory cytokines secreted by immune cells, adipose tissue , Muscles is able to accelerate or inhibit the inflammatory processes .High circulating IL-6 levels have been associated with insulin resistance and greater risk of T2DM .
80 patients with type 2 diabetes mellitus (40 male and 40 female )are diagnosed by specialized in medicine in general Salah- Aldin Hospital in Tikrit city and 40 apparently healthy Controls (20 male and 20 female ) were included in this study This study carried out in Tikrit city from 1st October 2017 to 1st of April 2018 Anthropometric measures include, Age , BMI , were done for all participants Fasting serum samples were obtained and used for the measurement of serum glucose Interleukin- 6 (IL-6) and Tumor necrosis factor alpha (TNF-α) .
The results of current study showed that Fasting serum glucose (FBS), Interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-α) are High significant increase (p<0.01) in diabetic patients when compared to control group.
In Conclusion, serum interleukin -6 (IL-6) and Tumor necrosis factor – alpha (TNF-α) has high significant increases level in diabetic patients compared to control.
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