Evaluation the Iron status and some electrolytes balance in patients with chronic renal failure

Main Article Content

Wissam Sabhan Khalaf
Wasan Nazhan Hussein
Amina Hamid Ahmed

Abstract

Background: In developing countries, chronic kidney disease (CKD) associated with anaemia is one of the major public health problems. With the progression of the disease, development of haematological abnormalities including iron deficiency increases. Renal anaemia may further increase the morbidity in these patients. Therefore, earlier detection and treatment of anaemia may be helpful in preventing the progression of the diseases and its other adverses (complications) outcomes.


Materials and Methods : The study included estimation of the level of iron , some electrolytes  with the determination of effect of body mass on all biochemical variables in the serum of healthy people the number (40) sample and people with chronic renal failure the (90) sample.


Results: The Results indicate that the levels of serum iron ,Total iron-binding capacity (TIBC) ,Transferrin Saturation (T.S), haemoglobin , PCV, calcium and magnesium were Significantly Decreased  in Patients group as compared with control and Significant Height in phosphate level (P≤0.01) in Patients group as compared .

Article Details

How to Cite
Wissam Sabhan Khalaf, Wasan Nazhan Hussein, & Amina Hamid Ahmed. (2019). Evaluation the Iron status and some electrolytes balance in patients with chronic renal failure. Tikrit Journal of Pure Science, 24(4), 47–51. https://doi.org/10.25130/tjps.v24i4.398
Section
Articles

References

[1] Dewardener HE. (1986). An outline of normal and abnormal function in the kidney. 4th edition Churchill Livingstone. New York:181-235.

[2] Jha V, Garcia GG, Iseki K, Zuo L, Naicker S,

Plattner B, et al. (2013). Chronic kidney disease: global dimension and perspectives. 382(9888):260-72.

[3] Barsoum RS.(2006) Chronic kidney disease in the developing world. N Engl J Med. 354; 991-997.

[4] Charmaine EL, Matthew JO, Deanna MR, Janet EH. (2004) The growing volume of diabetes- related dialysis: a population based study. Nephrology Dialysis Trans plantation .19;3098-3103.

[5] Rajapurkar MM, John GT, Kirpalani AL, Abraham G, Agarwal SK, Almeida AF, et al .(2012). What do we know about chronic kidney disease in India: first report of the Indian CKD registry. BMC Nephrol.;13:10.

[6] Agarwal SK, Srivastava RK. (2009) Chronic kidney disease in India: challenges and solutions. Nephron Clin Pract. 111;197-203.

[7] Mehdi U, Toto RD. (2009) Anaemia, diabetes, and chronic kidney disease. Diabetes Care. 32(7):1320-6.

[8] Sweny P, Farrington K, Moorhead JF. (1989) Chronic renal failure in the kidney and its disorders. 9th editio. New Delhi, India. Jaypee Medical. 359-369.

[9] Brugnara C. (2003). Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem. 49 ; 1573-1578.

[10] Wish JB. (2006). Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephro l.(1) :4-8.

[11] Madhusnata D, Halder A, Podder S, Sen R,

Chakrabarty S, Sengupta B, et al. (2006) Anemia and hemoglobinopathies in tribal population of Easrtern and North-eastern India. Hematology,11(5):371-376.

[12] Mohanty D, Gorakshakar AC, Roshan B, Colah R, Patel Z, Dilip C, et al.(2014). Interaction of iron deficiency anaemia and hemoglobinopathies among college students and pregnant women: a multi-center evaluation in india .38(4):252-257.

[13] Judith Blaine. ( 2015 ) . Michel Chonchol and Moshe Levi Renal Control of Calcium, Phosphate, and Magnesium Homeostasis. Clin J Am Soc Nephrol. 10; 1257–1272,.

[14] Young D.S. (1995),Effect of Drugs on Clinical Laboratory Tests . 4th Ed p.361-364.

[15] Tietz. N.W. (2007). Clinical Guide to Laboratory Test .4th Ed. p.1062 – 1065

[16] Konieczny, A. and Ausubel, F.M.A. (1993). procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers". Plant J. 4 : 403–410.

[17] Burtis, E.R.(1995) Scandinavian Joumal of Clinical and laboratory Tests.191-306.

[18] Tietz N.W. Ashwood, W. B. Saunders. (1999) . Text book of clinical chemistry,3rd Ed.CA. p.1245-1250.

[19] Rumi Deori1. (2016). Bedanta Bhuyan, Iron status in chronic kidney disease patients, International Journal of Research in Medical Sciences. Aug; 4(8): 3229-3234.

[20] Rachelle Bross, Jennifer Zitterkoph . Juhi Pithia . Deborah Benner, Mehdi Rambod. Csaba P. Kovesdy. (2009). Association of Serum Total Iron-Binding Capacity and Its Changes Over Time with Nutritional and Clinical Outcomes in Hemodialysis Patients, Am J Nephrol. 29:571–581.

[21] Al-Bayati, Alaa Mohammed Hamid. (2016). studied some immunological and bio chemical indicators in patients Renal Failure in Diyala Governorate, Master Thesis,.

[22] Manahil. Z. Ahmed ; I. M. T. Fadlalla ; Amel. O. Bakheit .(2018). Association of Uric Acid, Urea and Creatinine with Body Mass Index, Age and Gender . December . 1858-6716 .

[23] Akram Ghadiri-Anari, Narjes Nazemian, and Hassan-Ali Vahedian-Ardakani. (2014) . Association of Body Mass Index with Hemoglobin Concentration and Iron Parameters in Iranian Population.p. 3.

[24] Hea Shoon Lee .(2017). Comparison of Serum Iron, Total Iron Binding Capacity and hemoglobin A1c level according to Obesity in South Korean Adult . International Journal of Applied Engineering Research ; p15830-15837 .

[25] Olutayo Ifedayo Ajayi1, David Bolaji Akinbo and Adaobi Mary-Joy Okafor (2017). Correlation between Body Mass Index and Hematological Indices in Young Adult Nigerians with Different Hemoglobin Genotypes. American Journal of Biomedical Sciences . p: (5)

[26]. Bro S. (2003). “How abnormal calcium, phosphate and parathyroid hormone relate to cardiovascular disease”. Nephrol. Nurs. J; 30 (3): 275-283.

[27] Kaplan L.A., Amadeo J. Pesce and Steven C. K. (2003), "Methods in clinical chemistry". 4th ed. Mosby – U.S.A. p 113.

[28] Levine C. and Colburn J.W.(1984). “Magnesium the mimiclantagonist of calcium”. N. Engl. J. Med. 19:1253-1254

[29] Lutfi, Mohamed Faisal . (2014). Effects of age, body mass index and electrolytes levels on blood pressures of normotensive adults. Khartoum Medical Juornal . 5 : 673 - 681 .

[30] Natalia Campos-Obando, W Nadia H Koek, Elizabeth R Hooker, Bram CJ van der Eerden, Huibert A Pols, Albert Hofman, atel . (2017). Serum Phosphate Is Associated With Fracture Risk. Journal of Bone and Mineral Research . p 1182–1193.