The effect of L-Arginine of treatment for infertile men on semen parameters
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Abstract
The aim of the study is to determine the effect of oral supplement of L-Arginine on semen parameters as a treatment for infertile men. Patients and methods: The study conducted on 15 infertile men at infertility clinic in SalahadDin general hospital and private clinics and laboratories in Tikrit city from beginning of March to the end of July 2018. Infertility is a common clinical problem affecting 13-15% of couples worldwide. The prevalence varies throughout developed and undeveloped countries, being higher in the latter in which limited resources for diagnosis and treatment exist. L-arginine was given daily and orally at a dose 1000 mg one capsule per day morning after breakfast.
Results: There was a significant increase in total sperm count after treatment with L- Arginine as compare with that before treatment. Also there was significant elevation active motility and Ejaculate volume after treatment with L- Arginine, as compare with that before treatment. However, there are significant reductions in Sluggish motility, abnormal sperm shape and non-motile sperms after treatment with L-Arginine as compare with that before treatment.
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References
[1] WHO Manual for the Standardised Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press, 2000 .
[2]-Kollettis PN , (2003). Evaluation of the subfertile man Am Fam Physician; 67: 2165-73.
[3] - Forti , G., Krausz, C,(1998) . Evaluation and Treatment of the Infertile Couple. The J.of Clin Endocr. And Metab.;83 (12):4177-4188.
[4] Jeulin C, Lewin ML, (1996). Role of L-Arginine in postgonadal maturation of mammalian spermatozoa. Hum. Reprorepost. Update; 2: 87-102.
[5] Guzick DS , Overstreet JW, Litvak PM, Brazil CK , Steven T, Nakajima , et al, (2001). Sperm morphology, motility and concentration in fertile and infertile men . N Engl J med .; 345: 1388-93 .
[6] Geidam AD, tawe kdt, Adebayo AEA,(2008). hormonal profile of men nvestigated for infertility at the university of Maiduguri in northern Nigeria. Singaporemed J,; 49: 538-541.
[7] Ekwere Pd, Archibong EE, Bassey EE et a,l(2007). Infertility among Nigerian couples as seen in calabar. Port. Harcout. Med .J,; 2: 35-40.
[8] Mathur N, pandey G and jain GC,(2010). male reproductive toxicity of some selected metals: a review. J bio sci,;10: 396-404.
[9] Wiersema, N.; Drukker, A.Dung, M.(2006). Consequences of infertility in developing countries: results of a questionnaire and interview survey in the South of Vietnam. J. Trans. Med. 4: 54.
[10] Martens-Lobenhoffer J, Bode-Boger SM,(2014). Mass spectrometric quantification of L-arginine and its pathway related substances in biofluids: the road to maturity. J Chromatogr B Analyt Technol Biomed Life Sci;964:89–102.
[11] Hupertan, V., Neuzillet, Y., Stȕcker, O., Pons, C., Leammel, E., Lebret, T,( 2012). Effects of Nucleotides Adenosine Monophosphate and Adenosine Triphosphate in Combination with L-Arginine on Male Rabbit Corpus Cavernosum Tissue. International Journal of Andrology. 35 (6): 860-866.
[12] Baker HWG, Burger HG , de krester DM Hudson B,(1986). Relative incidence of etiological disorder for male infertility infertility ,in : R.J. Santen, R.S. Swerdl off (Eds.), male Reproductive Dysfunction, Marcel Dekker, New York ,p.350.[13] - world Health Organization. WHO,(1999). laboratory manual for the examination of human semen and sperm –cervical mucus interaction . 4th ed. Cambridge University Press. Cambridge. England.
[14] Marbut MM. Ihsan, M. Ezedeen, F. Abdul-Ghani, M. (2006). Elemental Analysis of Human Semen. Tikrit Med. J.; 12(1):47-52.
[15] Agarwal, A., Sharma, R,(2007). Automation is the key to standardized semen analysis using the automated SQA-V sperm quality analyzer. Fertility and Sterility Vol. 87, No. 1, January
[16] Botsoglou N A, Fletouris D J, Papageorgiou G E,(1994), Vassilopoulos V N, Mantis A J, Trakatellis A G Rapid, Sensitive And Specific Thiobarbituric Acid Method for measuring lipid peroxidation in animal tissue, food and feedstuff samples. Agric Food Chem 42: 1931–37
[17] Agarwal, A., Sharma, R,(2007). Automation is the key to standardized semen analysis using the automated SQA-V sperm quality analyzer. Fertility and Sterility Vol. 87, No. 1, January
[18] Menkveld, R.(2001).Semen parameters including WHO and strict criteria morphology in a fertile and sub-fertile population: An effort towards standardization of in-vivo thresholds. Human reproduction; 16 (6):1165-1171.
[19] - Husein, RH., Ahmed, MO., and Muhammed, SM, (2011). Effects of L-Arginine, Vitamin E and Their Combinations on Sperms Morphology in Albino Male Mice. Journal of Al-Nahrain University. 14 (2): 137-143.
[20] Balercia G, Regoli F, Armeni T, et al, (2005). Placebo-controlled, double-blind, randomized trial on the use of L -carnitine, L -acetylcarnitine, or combined L -carnitine and L -acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril 2005; 84: 662–671.
[21] Sheweita SA, Tilmisany AM, Al-Sawaf H,(2005). Mechanisms of male infertility: role of antioxidants. Curr Drug Metab.; 6: 495-501.
[22] Fafula, RV., Iefremova, UP, Olena K. Onufrovych, (2018). Alterations in Aeginase -NO- Synthase system of spermatozoa of in human subjects with different fertility potential. J. Med. Biochem. 37: 134 –140.
[23] O Flaherty C, De Lamirande E, Gagnon C, (2004). Phosphorylation of the Arginine –X-X-(Serine-Threonine) motif in human sperm proteins during A dependency. Molecular Human Reproduction.; 10: 355-363.
[24] Srivastava S, Desai P, Coutinho E, Govil G, (2006). Mechanism of action of L- arginine on the vitality of spermatozoa is primarily through increased biosynthesis of nitric oxide . Biol Reprod, 74: 954-958.
[25] Srivastava S, Desai , Coutinho E, Govil G, (2006). St. Louis: The CV Mosby.
[26] Elgun S, Kacmaz M, Sen I et al. (2000). Seminal arginase activity in infertility. Urological Research, 28: 20-23.
[27] Hassan, HY,( 2019) .Role of varicocelectomy in improving fertility in infertile male with varicocele. J. of Madent Alelem College; 11(1): 19-26.