The polymorphism of Apelin gene rs2235306 and serum Apelin level in breast cancer women in Samarra- Iraqi population
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Abstract
Breast cancer (BC) is the most common cancer leading to death in women and the fifth type of cancer leading to death worldwide, The study was done on 59 women, including 20 non-breast cancer women as a control group, their ages ranged from (30-74years) and 39 women with breast cancer their ages ranged from (29-80years).The results showed significant increase (p ≤0.05) in the concentration of Apelin in women with BC compared with non-breast cancer women, This finding suggests that Apelin may promoted carcinogenesis. The result of Apelin rs2235306 polymorphism using T-ARMS-PCR technique show no difference in the allele frequencies between BC patients and control group, the results also show that there is no association of the observed genotypes (TT&TC) with serum Apelin concentration in the studied Population. The result of the study suggest that the serum Apelin level can be independent of Apelin rs2235306 polymorphism which should be confirmed by further studies on larger populations.
The aim: The aim of this study was to determine Apelin level in serum and apln rs2235306 polymorphism in breast cancer (BC) patients in Samarra city-Iraq.
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