Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

Article Sidebar

pdf
Published: Dec 23, 2019
DOI: https://doi.org/10.25130/tjps.v24i7.450
Keywords:
Endothelin-1, Vitamin D, Chronic renal disease, Acute Renal Disease

Main Article Content

Ihsan Maher Abdul Amir
Moafaq Mutlak Zeidan

Abstract

Chronic renal disease is a worldwide public health problem with an increasing incidence, prevalence, poor outcomes, and high cost. A cross-sectional study was carried out in balad city from 10th of November 2018 to 15th of March 2019. The number of patients under  study were 60 patients with renal disease (30 acute renal disease and 30 chronic renal disease under hemodialysis). Their ages were between (20-75) years. Patients with acute renal disease were admitted to Balad general hospital and patients with chronic renal disease who admitted to Salahaddin general hospital for hemodialysis. The study included 30 apparently healthy subject as control group. The results showed that the highest mean level of endothelin-1 was found in patients with chronic renal disease (13.15±7.81)pg/ml followed by patients with acute renal disease (1.78±1.49) pg/ml compared with  the control group (0.41±0.31) pg/ml. These result were significant higher (P< 0.01). The results  showed that the lowest mean level of vitamin D was found in patients with chronic renal disease (14.45±5.92) ng/ml followed by patients with acute renal disease (23.49±13.14) ng/ml compared with the control group (24.02 ±8.22) ng/ml. The results were significant higher than control (P≤0.01). The study showed that patients with acute renal disease were distributed equally to male and female (1:1) while 56.67% of patients with chronic renal disease were males. The conclute from this study that the endothelin elevated in chronic renal disease patients and vitamin D was reduced.

Article Details

How to Cite
Ihsan Maher Abdul Amir, & Moafaq Mutlak Zeidan. (2019). Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease. Tikrit Journal of Pure Science, 24(7), 1–5. https://doi.org/10.25130/tjps.v24i7.450
Issue
Vol. 24 No. 7 (2019)
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.

References

[1] Brophy, P.D., Charlton, J.R., Carmody, J.B., Reidy, K.J., Harshman, L., Segar, J., Askenazi, D., Shoham, D. and Bagby, S.P., (2018). Chronic renal disease: A life course health development perspective. In: Handbook of Life Course Health Development. Springer, Cham: 375-401.

[2] Akchurin, M. and Kaskel, F., (2015). Update on inflammation in chronic renal disease. Blood purification, 39(1-3): .84-92.

[3] Edelstein, C.L. (2016). Biomarkers of renal disease. 1st edn. Academic press: 109 pp.

[4] Komers, R. and Plotkin, H., (2016). Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic renal disease. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 310(10): .877-884.

[5] Ramkumar, N., Stuart, D., Abraham, N. and Kohan, D.E., (2018). Nephron Prorenin Receptor Deficiency Alters Renal Medullary Endothelin-1 and Endothelin Receptor Expression. Physiological Research, 67(1): 127-136.

[6] Lu, R. J. et al. (2017). Effects of vitamin D or its analogues on the mortality of patients with chronic renal disease: an updated systematic review and meta-analysis. European Journal of Clinical Nutrition, 71(6): 683-687.

[7] Carrero, J. J., Hecking, M., Chesnaye, N. C. and Jager, K. J. (2018). Sex and gender disparities in the epidemiology and outcomes of chronic renal disease. Nature Reviews Nephrology, 14(3): 151-156.

[8] Dogara, L. G. et al. (2018). Influence of Age and Gender on the prevalence of anaemia in dialysis naïve Patients with chronic renal disease (CKD) in Zaria, Nigeria. Tropical Journal of Nephrology, 13(2): 69-76.

[9] Larivière, R. and Lebel, M. (2003). Endothelin-1 in chronic kidney failure and hypertension. Canadian Journal of Physiology and Pharmacology, 81(6): 607-621.

[10] Rebholz, C. M. et al. (2017). Association between endothelin-1 levels and renal disease among blacks. Journal of the American Society of Nephrology, 28(11): 3337-3344.

[11] Shah, R. (2007). Endothelins in health and disease. European Journal of Internal Medicine, 18(4): 272-282.

[12] El-Shafey, E. M., El-Nagar, G. F., Selim, M. F., El-Sorogy, H. A., and Sabry, A. A. (2008). Is there a role for endothelin-1 in the hemodynamic changes during hemodialysis. Clinical and Experimental Nephrology, 12(5): 370-375.

[13] Dhaun, N. et al.(2015). Plasma Pro‐Endothelin‐1 Peptide Concentrations Rise in Chronic Renal disease and Following Selective Endothelin A Receptor Antagonism. Journal of the American Heart Association, 4(3): e001624

[14] Wang, C. et al. (2015). Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic renal disease. Hypertension, 65(5): 1055-1063.

[15] Lawson, J., Elliott, J., Wheeler-Jones, C., Syme, H. and Jepson, R. (2015). Renal fibrosis in feline chronic renal disease: known mediators and mechanisms of injury. Veterinary Journal, 203(1): 18-26.

[16] Zoja, C. et al. (2015). Effects of MCP-1 inhibition by bindarit therapy in a rat model of polycystic renal disease. Experimental Nephrology, 129(1): 52-61.

[17] Firth, J. D., Raine, A. E. G., Ratcliffe, P. J. and Ledingham, J. G. G. (1988). Endothelin: an important factor in acute renal failure?. The Lancet, 332(8621): 1179-1182.

[18] Guan, Z., Van Beusecum, J. P. and Inscho, E. W. (2015). Endothelin and the renal microcirculation. Seminars in Nephrology, 35(2): 145-155.

[19] Yasmin, T. and Siddiqui, M. S. I. (2018). Prevalence of Vitamin D & Renal Dysfunction in Metabolic Syndrome. International Archives of BioMedical and Clinical Research, 4(2): 179-183.

[20] Nakashima, A., Yokoyama, K., Yokoo, T., & Urashima, M. (2016). Role of vitamin D in diabetes mellitus and chronic renal disease. World Journal of Diabetes, 7(5): 89.

[21] Bhan, I. et al. (2015). Nutritional vitamin D supplementation in dialysis: a randomized trial. Clinical Journal of the American Society of Nephrology, 10(4): 611-619.

[22] Lundwall, K., Jacobson, S. H., Jörneskog, G. and Spaak, J.(2018). Treating endothelial dysfunction with vitamin D in chronic renal disease: a meta-analysis. BMC Nephrology, 19(1): 247-252.

[23] Bischoff-Ferrari, H. A., Giovannucci, E., Willett, W. C., Dietrich, T. and Dawson-Hughes, B. (2006). Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. The American Journal of Clinical Nutrition, 84(1): 18-28.

[24] Nigwekar, S. U., Bhan, I. and Thadhani, R. (2012). Ergocalciferol and cholecalciferol in CKD. American Journal of Renal diseases, 60(1): 139-156.

[25] Levin, A. et al. (2007). Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic renal disease: results of the study to evaluate early renal disease. Kidney International, 71(1): 31-38.

[26] Ravani, P. et al. (2009). Vitamin D levels and patient outcome in chronic renal disease. Kidney International, 75(1): 88-95.

[27] Valle, E. D., Negri, A. L., Aguirre, C., Fradinger, E. and Zanchetta, J. R. (2007). Prevalence of 25 (OH) vitamin D insufficiency and deficiency in chronic renal disease stage 5 patients on hemodialysis. Hemodialysis International, 11(3): 315-321.

[28] Kleine, C. E. et al. (2019). Seasonal variation of serum 25-hydroxyvitamin D and parameters of bone and mineral disorder in dialysis patients. Bone, 124: 158-165.

[29] Ahmadi, F. et al (2016). Association of low vitamin D levels with metabolic syndrome in hemodialysis patients. Hemodialysis International, 20(2): 261-269.

[30] Mohiuddin, S. A., Marie, M., Ashraf, M., Hussein, M. and Almalki, N. (2016). Is there an association between Vitamin D level and inflammatory markers in hemodialysis patients? A cross-sectional study. Saudi Journal of Renal diseases and Transplantation, 27(3): 460-466.

[31] Brar, A. and Markell, M. (2019). Impact of gender and gender disparities in patients with renal disease. Current Opinion in Nephrology and Hypertension, 28(2): 178-182.

[32] Goldberg, I. and Krause, I. (2016). The role of gender in chronic renal disease. European Medical Journal, 1(2): 58-64.

[33] Ito, J., Kita, H. and Fujisawa, T. (2018). Significance of early detection of acute kidney function worsening among outpatients having CKD using automatic calculation system for the rate of eGFR decline. Clinical and Experimental Nephrology, 22(4): 898-905.