The Potential Effect of Grape Seeds Extract against Lead toxicity That Induces Infertility to Male Rats
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Abstract
The present study was designed to find the role, of grape seed extract against lead toxicity. Study was used 25 male rats that divided randomly to five groups (5 rats in each group) and the treatment continue four week in each group, control group administrated with normal saline, rats group treatment with (orally) lead (Pb), third group received lead (Pb) 100mg/kg and 50mg/kg seed extract, fourth group received lead (Pb) and 100mg/kg seed extract, fifth group received lead (Pb) and 200mg/kg seed extract. Rats group received lead show significant (P<0.05) decrease in counts, motility of sperm and increase the deformity of sperms. Other wise, rats group received lead show significant (P<0.05) decrease in glutathione (GSH), catalase (CAT) and increase levels of malonedialdehyied (MDA) compared with control group. The treated group with seed extract at different doses, sperm parameters and oxidative stress show gradual recovery. In 200mg/kg dose of seed extract, all parameters of study back to the normal ranges. It was concluded from this study that grape seed extract has important role against toxicity of lead in male rats.
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