Association of Adipocytokines and Vitamin D Status in Tuberculosis
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Abstract
Leptin and Adiponectin are considered principal indicators of tuberculosis (TB). They are critical parts of the pathophysiological processes to which treatment can be applied. Thus, this research aimed at finding out the role of Adipocytokines and 25-dihydroxy vitamin D in the aetiology of tuberculosis. The research sample included (90) participants divided into (50) tuberculosis patients and (40) healthy subjects representing the control group who were age and sex-matched. Circulating levels of adipocytokines and 25- dihydroxy vitamin D were analysed by using ELISA techniques. Compared to the subjects of control group, tuberculosis subjects had significantly (P<0.0001) lower levels of serum leptin (5.84±1.83 pg/mL) and vitamin D (2.77±0.52 ng/mL). However, compared to their control counterparts, tuberculosis patients had significantly (P<0.0001) higher levels of adiponectin (16.30±1.23 ng/mL). The ROC curve analysis of Leptin, Adiponectin, and 25-dihydroxy vitamin D indicated a high diagnostic value in predicting the risk of tuberculosis. The present study findings revealed that elevated serum adiponectin with decreased serum leptin levels and hypovitaminosis D are strongly correlated with the pathogenesis and state of tuberculosis.
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References
[1] Chakaya, J., Khan, M., Ntoumi, F., et al. (2021). Global Tuberculosis Report 2020–Reflections on the Global TB burden, treatment and prevention efforts. International Journal of Infectious Diseases, 113, S7-S12.
[2]Mahmood, K. A. (2019). Histological and Epidemiological study on Mycobacterium tuberculosis in Nineveh Governorate. Tikrit Journal of Pure Science, 24(1), 13-22
[3] Gill, C. M., Dolan, L., Piggott, L. M., et al. (2022). New developments in tuberculosis diagnosis and treatment. Breathe, 18(1).
[4] Gopalaswamy, R., Dusthackeer, V., Kannayan, S., et al. (2021). Extrapulmonary Tuberculosis—An Update on the Diagnosis, Treatment and Drug Resistance. Journal of Respiration, 1(2), 141-164.
[5] Koegelenberg, C. F., Schoch, O. D., & Lange, C. (2021). Tuberculosis: the past, the present and the future. Respiration, 100(7), 553-556.
[6] Ghoshal, K., & Bhattacharyya, M. (2015). Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World journal of diabetes, 6(1), 151.
[7] Al-Youzbaky, Z. M., & Abdulla, Z. A. (2015). Serum leptin level in rheumatoid arthritis and its relationship with disease activity. Tikrit Journal of Pure Science, 20(2), 49-53
[8] Zheng, Y., Ma, A., Wang, Q., et al. (2013). Relation of leptin, ghrelin and inflammatory cytokines with body mass index in pulmonary tuberculosis patients
with and without type 2 diabetes mellitus. PloS One, 8(11), e80122.
[9] Ye, M., & Bian, L.-F. (2018). Association of serum leptin levels and pulmonary tuberculosis: a meta-analysis. Journal of Thoracic Disease, 10(2), 1027.
[10] van Crevel, R., Karyadi, E., Netea, M. G., et al. (2002). Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation. The Journal of Clinical Endocrinology & Metabolism, 87(2), 758-763.
[11] Moideen, K., Kumar, N. P., Nair, D., et al. (2018). Altered systemic adipokine levels in pulmonary tuberculosis and changes following treatment. The American Journal of Tropical Medicine and Hygiene, 99(4), 875.
[12] Elnemr, G. M., Elnashar, M. A., Elmargoushy, N. M., et al. (2015). Adiponectin levels as a marker of inflammation in pulmonary tuberculosis. The Egyptian Journal of Hospital Medicine, 59(1), 208-213.
[13] Wang, C.-Y., Hu, Y.-L., Wang, Y.-H., et al. (2019). Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012. Infection and drug resistance, 12, 2251.
[14] Mexitalia, M., Dewi, Y. O., Pramono, A., et al. (2017). Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children. Korean journal of pediatrics, 60(4), 118.
[15] Farooqi, I. S., & O’Rahilly, S. (2009). Leptin: a pivotal regulator of human energy homeostasis. The American journal of clinical nutrition, 89(3), 980S-984S.
[16] MacIver, N. J., Jacobs, S. R., Wieman, H. L., et al. (2008). Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. Journal of leukocyte biology, 84(4), 949-957.
[17] Chan, E. D., & Iseman, M. D. (2010). Slender, older women appear to be more susceptible to nontuberculous mycobacterial lung disease. Gender medicine, 7(1), 5-18.
[18] Kim, J. H., Lee, C.-T., Yoon, H. I., et al. (2010). Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis. Clinical Nutrition, 29(4), 512-518.
[19] Herlina, M., Nataprawira, H., & Garna, H. (2011). Association of serum C-reactive protein and leptin levels with wasting in childhood tuberculosis. Singapore medical journal, 52(6), 446.
[20] Ghantous, C., Azrak, Z., Hanache, S., et al. (2015). Differential role of leptin and adiponectin in cardiovascular system. International journal of endocrinology, 2015.
[21] Yüksel, İ., Şencan, M., Sebila Dökmetaş, H., et al. (2003). The relation between serum leptin levels and body fat mass in patients with active lung tuberculosis. Endocrine Research, 29(3), 257-264.
[22] Mansour, O. F., Khames, A. A., Radwan, E. E.-D. I., et al. (2019). Study of serum leptin in patients with active pulmonary tuberculosis. Menoufia Medical Journal, 32(1), 217.
[23] Davis, J. F., Choi, D. L., Schurdak, J. D., et al. (2011). Leptin regulates energy balance and motivation through action at distinct neural circuits. Biological psychiatry, 69(7), 668-674.
[24] Stofkova, A. (2009). Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocrine regulations, 43(4), 157-168.
[25] Keicho, N., Matsushita, I., Tanaka, T., et al. (2012). Circulating levels of adiponectin, leptin, fetuin-A and retinol-
binding protein in patients with tuberculosis: markers of metabolism and inflammation. PloS One, 7(6), e38703.
[26] Santucci, N., D'Attilio, L., Kovalevski, L., et al. (2011). A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis. PloS One, 6(10), e26363.
[27] Yurt, S., Erman, H., Korkmaz, G., et al. (2013). The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis. Clinical biochemistry, 46(1-2), 40-44.
[28] Bacon, J., Alderwick, L. J., Allnutt, J. A., et al. (2014). Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix. PloS One, 9(2), e87329.
[29] Agarwal, P., Pandey, P., Sarkar, J., et al. (2016). Mycobacterium tuberculosis can gain access to adipose depots of mice infected via the intra-nasal route and to lungs of mice with an infected subcutaneous fat implant. Microbial pathogenesis, 93, 32-37.
[30] Rastogi, S., Agarwal, P., & Krishnan, M. Y. (2016). Use of an adipocyte model to study the transcriptional adaptation of Mycobacterium tuberculosis to store and degrade host fat. International journal of Mycobacteriology, 5(1), 92-98.
[31] Ayyappan, J. P., Vinnard, C., Subbian, S., et al. (2018). Effect of Mycobacterium tuberculosis infection on adipocyte physiology. Microbes and infection, 20(2), 81-88.
[32] Damouche, A., Lazure, T., Avettand-Fènoël, V., et al. (2015). Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection. PLoS pathogens, 11(9), e1005153.
[33] Choe, S. S., Huh, J. Y., Hwang, I. J., et al. (2016). Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Frontiers in endocrinology, 7, 30.
[34] Qiao, L., Kinney, B., Schaack, J., et al. (2011). Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes, 60(5), 1519-1527.
[35] Neyrolles, O., Hernández-Pando, R., Pietri-Rouxel, F., et al. (2006). Is adipose tissue a place for Mycobacterium tuberculosis persistence? PloS One, 1(1), e43.
[36] PrayGod, G. (2020). Does adipose tissue have a role in tuberculosis? Expert Review of Anti-Infective Therapy, 18(9), 839-841.
[37] Workineh, M., Mathewos, B., Moges, B., et al. (2017). Vitamin D deficiency among newly diagnosed tuberculosis patients and their household contacts: a comparative cross-sectional study. Archives of Public Health, 75(1), 1-7.
[38] Kearns, M. D., Alvarez, J. A., Seidel, N., et al. (2015). Impact of vitamin D on infectious disease. The American journal of the medical sciences, 349(3), 245-262.
[39] Esposito, S., & Lelii, M. (2015). Vitamin D and respiratory tract infections in childhood. BMC infectious diseases, 15(1), 1-10.
[40] Battersby, A. J., Kampmann, B., & Burl, S. (2012). Vitamin D in early childhood and the effect on immunity to Mycobacterium tuberculosis. Clinical and Developmental Immunology, 2012.
[41] Norval, M., Coussens, A. K., Wilkinson, R. J., et al. (2016). Vitamin D status and its consequences for health in South Africa. International journal of environmental research and public health, 13(10), 1019.
[42] Huang, S.-J., Wang, X.-H., Liu, Z.-D., et al. (2017). Vitamin D deficiency and the
risk of tuberculosis: a meta-analysis. Drug design, development and therapy, 11, 91.
[43] Keflie, T. S., Nölle, N., Lambert, C., et al. (2015). Vitamin D deficiencies among tuberculosis patients in Africa: a systematic review. Nutrition, 31(10), 1204-1212.
[44] Zeng, J., Wu, G., Yang, W., et al. (2015). A serum vitamin D level< 25nmol/l pose high tuberculosis risk: a meta-analysis. PloS One, 10(5), e0126014.
[45] Gou, X., Pan, L., Tang, F., et al. (2018). The association between vitamin D status and tuberculosis in children: A meta-analysis. Medicine, 97(35).
[46] Gupta, A., Montepiedra, G., Gupte, A., et al. (2016). Low vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is associated with tuberculosis and death in HIV-infected and-exposed infants. PloS One, 11(2), e0148649.
[47] Junaid, K., & Rehman, A. (2019). Impact of vitamin D on infectious disease-tuberculosis-a review. Clinical Nutrition Experimental, 25, 1-10.
[48] Talat, N., Perry, S., Parsonnet, J., et al. (2010). Vitamin D deficiency and tuberculosis progression. Emerging infectious diseases, 16(5), 853.
[49] Martineau, A. R., Timms, P. M., Bothamley, G. H., et al. (2011). High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. The Lancet, 377(9761), 242-250.