The Relation between Kidney Injury Molecule -1 and its role as promising biomarker in kidney stone patients
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Abstract
Urea and creatinine is the most sensitive markers of Kidney Diseases progression in clinical practice, especially when combined with GFR, but these have limitations. Hence, early, more sensitive, biomarkers are required. Recently, promising biomarkers have been identified for CKD progression such as kim-1 has been investigated as a novel biomarkers of kidney diseases progression. This study aimed to evaluate urinary Kidney Injury Molecule-1(KIM-1) in kidney stone patients.75 patients diagnosed with renal stone diseases and all patients were screened and followed up in the out-patients clinics in Salah Adin general hospital. controls were represented by 15 healthy volunteers. KIM-1, levels shows no significant changes within patients groups while shows that the KIM-1 levels were significantly increased in stone patients when compared with the healthy controls (P˂0.05). Total protein and S. Albumin levels significantly decreased in patients group compared to the controls levels while there was no significant changes within patients group. The current results suggest that KIM-1 can consider as promising biomarker for diagnosis, clinical progression and investigations for kidney stone diseases.”
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References
[1] Coe, F.L.; Worcester, E.M.; Andrew, P. E. (2016). Idiopathic hypercalciuria and formation of calcium renal stones. Nat Rev Nephrol. 2(9):519−533.
[2] Goraya, N. and Wesson, D.E. (2015). Dietary interventions to improve outcomes in chronic kidney disease. Curr. Opin.Nephrol. Hypertens., 24, 505–510.
[3] Lieske, J.C.; and Deganello, S. (1999). Nucleation, adhesion, and internalization of calcium-containing urinary crystals by renal cells. J. Am. Soc. Nephrol.10(Suppl. 14):S422–S429.
[4] Ahmed, S.A. and Hamed, M.A. (2015). Kidney injury molecule-1 as a predicting factor for inflamed kidney, diabetic and diabetic nephropathy Egyptian patients. J. Diabet Metab Disord.14:6-13.
[5] Vaidya, V.S.; Waikar, S.S.; Ferguson, M.A. et al.(2008). Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl. Sci.1: 200–8.
[6] Zhang, J.; Brown, R.P.; Shaw, M. et al. (2008). Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine. Toxicol Pathol 36: 397–409.
[7] Bailly, V.; Zhang, Z.; Meier, W. et al. (2002). Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem 277: 39739–39748.
[8] Ichimura, T.; Bonventre, J.V.; Bailly, V. et al. (1998). Kidney injury molecule-1(KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem. 273: 4135–4142. [9] Sabbisetti, V.S.; Ito, K. and Wang, C. et al. (2013). Novel assays for detection of urinary KIM-1 in mouse odels of kidney injury. Toxicol Sci. 131: 13–25.
[10] Bonventre, J.V. (2009). Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant 24: 3265–3268
[11] Han, W.K.; Bailly, V.; Abichandani, R.; et al. (2002). Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. ;62:237–244.
[12] van Timmeren, M.M.; Vaidya, V.S.; van Ree, R.M. et al. (2007). High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation; 84:1625–1630.
[13] Kondaveeti, S.K.; Mishra, S.; Kumar, R. and Shaker, I.A. (2013). Evaluation of glycated albumin and microalbuminuria as early risk markers of
nephropathy in type 2 diabetes mellitus. J Clin Diagn. Res. ;7(7):1280–3. [14] Landry, D.W. and Bazari, H. (2011). Approach to the Patient with Renal Disease. Pa: Saunders Elsevier. Chap 116. [15] Berk, P.D. and Korenblat, K.M. (2011). Approach to the Patient with Jaundice or Abnormal Liver Test Results: In Goldman L, Ausiello D, ed, Cceil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier: Chap 149.
[16] Lopez - Giacoman, S. and Madero, M. (2015). Biomarkers in chronic kidney disease, from kidney function to kidney damage. World J Nephrol.; 4(1):57–73. [17] van Timmeren, M.M.; Vaidya, V.S.; van Ree, R.M. et al. (2007). High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation; 84: 1625–1630.
[18] Kamalov, A.; Nizov, A. and Ohobotov, D. (2018). Change in the concentration of urolithiasis markers depending on the degree of activity of stone formation in patients with recurrent stone disease. Urology and Nephrology Open Access .8.53-61.
[19] Waanders, F.; Vaidya, V.S.; van Goor, H. et al. (2009). Effect of renin-angiotensinaldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial. Am J Kidney Dis.; 53: 16–25.
[20] Vaidya, V.S.; Ozer, J.S.; Dieterle, F. et al. (2010). Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol; 28: 478–485.
[21] El-Ashmawy, N.; El-Zamarany, E.; Khedr, N. et al. (2015). Kidney injury molecule-1 (Kim-1): an early biomarker for nephropathy in type II diabetic patients. International Journal of Diabetes in Developing Countries. 35.10-18.
[22] Kuehn, E.W.; Park, K.M.; Somlo, S.; Bonventre, J.V. (2002). Kidney injury molecule-1 expression in murine polycystic kidney disease. Am J Physiol Renal Physiol.;283(6):F1326- F1336.
[23] Kuehn, E.W.; Hirt, M.N.; John, A.K. et al. (2007). Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2. Biochem Biophys Res Commun. ;364(4):861-866.
[24] Meijer, E.; Boertien, W.E.; Nauta, F.L. et al. (2010). Association of urinary biomarkers with disease severity in patients with autosomal dominant polycystic kidney disease: a cross-sectional analysis. Am J Kidney Dis.;56(5):883-895.