Biochemical Study for Effect the Alcoholic Extract in of Thymus vulgaris lowering the Induced Toxicity of Liver and Kidney in Albino Mice
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Abstract
Biochemical study in the effect of alcoholic extract of Thymus vulgaris in lowering the incluced toxicity of liver and kidney in Albino Mice mice. The am of this study is to study the effect of Thymus vulgaris and investigate the ethanolic extract on the levels of liver and kidney enzymes of mice. Thirty albino mice average weight (25-30)gm were divided into 5 groups as follow:group1; has given normal diet as control group.
group2; (injected with carbon tetrachloride CCl4), group3 (injected with CCl4 + 0.5mg/ml Thymus vulgaris sativa extract), group4 (injected with CCl4 + 1mg/ml Thymus vulgaris extract), and group5 (injected with CCl4 + 2mg/ml Thymus vulgaris extract). Serum liver and kidney functions tests were estimated. The results showed that Thymus vulgaris extracts at concentration of 2mg/ml improved liver and kidney functions. This study concluded that, Thymus vulgaris extracts may exert their prophylactic and treatment role against oxidative stress caused by CCl4 by increasing/maintaining the levels of antioxidant enzymes. Biochemical detection showed the extract contains of tannins, glycosides and oils that the Thymus leaves,
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References
3- N. Nakatani, (2000), Phenolic antioxidants from herbs and species. Biofactors, 13 (1), P( 141 – 146).
4- Association scientific committee, (1983), British herbalpharmacopia. Published by British medicine association.
9- Jamshidzadeh, Akram., Khoshnood, Mohammad Javad., Zahra Dehghani and Hossein Niknahad, (2006), Hepatoprotective Activity of Cichorium intybus L. Leaves Extract Against Carbon Tetrachloride Induced Toxicity. Iranian Journal of Pharmaceutical Research 1,P( 41-46).
11- Sofowora A., (1982), Medicinal plants and Traditional Medicine in Africa, John Wiley and Sons Ltd., p(142-145).
12-Shihata, I. M, (1951), A pharmacological study of Anagallis arvensis, M.Sc. Thesis, faculty of Vet. med. Cairo univ. Egypt.
13- Burtis, C. A., and Ashwood, E. R., (1999), Text Book of clinical chemistry, 3rded., W. B., Saunders company, London, UK., p.(840-843).
14- Reitaman, S. and Franker, S., (1957), A colorimetric method for the determination of serum glutamic oxaloacetatic and glutamic pyruvic transaminases., J. Clin. Path.18, P( 8-9) .
15- Azaz, A. D., H. A. Irtem., M. Kurkcuoglu and K. H. Baser, (2004), Composition and the in vitro antimicrobial activities of the essential oils of some Thymus species. J. Z. Naturforsch., 59(1-2), P(75-80).
16- cheij. R., (1984), Mcdonald Encyclopedia of medicinal plant , McDonald and Co.(publishers) Ltd.
London.
- 18 Nakatani N. , (1997) , Antioxidants from spices and herbs. In: Natural antioxidants: chemistry, health effects, and applications, Shahidi, F. Ed. Aocs Press: Champaign, p. (64-75) , (Abstract).
19- Seung-Joo L.; Katumi U. , (2005). Takayuki S. and Kwang-Geun L., Identifi cation of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. Food Chem. 91, P( 131-137).
20- Hirasa K. and Takemasa M. (1998). Spice Science and Technology, Marcel Dekker: New York.
(Cited by: Kdhkonen 1999 )
22. M . K . Turkdogan and H. Hekim, (1998), Lipid peroxidation and upper gastrointestinal cancer, Eastern J . Med . 3(2), P( 39 – 42).