Histological Effects of Aqueous Extract of Saffron Flowers Crocus sativus on Ovaries and Oviduct of Females White Mice Mus musculus
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Abstract
The present study was conducted to identify the histological effects of the aqueous extract of saffron flower on ovaries and oviducts of the adult female mouse at doses of 15, 30 and 60 mg/kg of body weight (b.w.).for the periods 7,15 and 30 days, respectively and once a day. Behavioral changes were include the abnormal hyperactivity, irritability followed by introversion and reduction of motor activity, as well as loss of appetite for food and drinking water for several hours. The results showed histopathological changes of mice ovaries at a dose of 15 mg /kg of B.W. for the above periods a slight increase in primordial follicles, congestion of blood vessels, necrosis and degeneration. At a dose of 30 mg/kg. there was slight deposition of hyaline material, deposition of hemosiderin dye, congestion and increase of primordial follicles numbers, while at a dose of 60 mg/kg lymphatic cells infiltration were observed, with some ovarian stromal cells decaying. while the oviduct, and for the above periods changes included thickening of canal wall, endothelial cells degeneration and blood vessel congestion in the muscular area at a dose of 15 mg/kg, increased flattening of the mucosal folds also was observed. At a dose of 30mg /kg. an increased damage with increased blood vessels congestion, fibrosis of oviduct wall and degeneration of the external muscle layer of the oviduct at a dose of 60 mg /kg was obvious.
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