Evaluation of Lipid Profile changes in children with urinary tract infections
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Abstract
Back ground: many researches about urinary tract infection has been conducted on adults but very little has been done on children. Therefore, this research is novel in Salahaddin city-Iraq.
Urinary tract infection is a bacterial infection that affects part of the urinary tract. It affects the lower urinary tract as well as upper urinary tract. It is characterized by painful urination, urge to urinate or sometimes frequent urination. Other symptoms include fever in addition to flank pains.
Bacteria infections cause a variety of changes in lipid profile concentrations by generating free radicals. Free radicals are reactive species generated by biochemical redox interactions that occur as a part of normal cell metabolism. These free radicals may cause lipid peroxidation and damage cellular structures of organism particularly erythrocytes and endothelium. Lipid peroxidation are free radicals mediated chain of reaction that, once initiated, results in oxidative deterioration of polyunsaturated lipids. The most common goal are components of biological membrane. When propagated in biological membranes, these reaction can be initiated or enhanced by a number of toxic products, including endoperoxides and aldehydes.
Aim: The aims of this study were to evaluate the lipid profile of the children in acute phase of urinary tract infections.
Methodology: Case-control study was designed to evaluate the lipid profile change in children with lower UTI. The study was performed on 130 children with ages between (4 – 12) years, 90 children with lower UTI (34.4% male) and (65.6% female,) and 40 control (45.0% male) and (55.0% female) in pediatric department of Salahaddin Teaching hospital from May 2017 till October 2017. The data were analyzed through the SPSS V.23 application, descriptive data analysis was done through frequency, percentage, mean, standard deviation in addition to T-test to compare results.
Results: The results showed there was a significant decreased in the levels of Cholesterol, LDL, and HDL when compared to control group (144.02±17.69, 75.76±12.695, and 44.66±8.742 vs 167.65±13.13, 89.73±13.45, and 60.95±6.26 respectively), while there were a significant increase in triglycerides and VLDL in study group when compared to control group (118.03±18.66, and 23.56±3.76 vs 85.95±10.25, and 17.28±2.063 respectively).
Conclusion: These observation shows that low levels of lipid, particularly total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and increased triglycerides (TG) probably be
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