Serotonin, Endorphin Concentrations and Some Hematological Parameters in Male Narghile Smokers

Main Article Content

Salim Jasim Khalaf
Mahdi Salh Hamad
Nahla Kamal Asaad

Abstract

This study was carried out to evaluate the relationship between narghile smoking and serum concentration of serotonin and endorphin and some blood hematological indices in males. Group of smokers composed of 50 voluntary, and control group composed of 36 healthy voluntary. This study was conducted on adults man that ages between (18-25 years). The markers measured in this study were serum serotonin and endorphin and hematological indices (platelets, hematocrit, hemoglobin, and white blood cells).


This study showed a significant decrease (P<0.05) in levels of serum serotonin, endorphin and blood platelets, and a significant increase (P<0.05) in levels of in blood hematocrit and hemoglobin and a non-significant increase of white blood cells (P>0.05) in smokers as compared with healthy persons.

Article Details

How to Cite
Salim Jasim Khalaf, Mahdi Salh Hamad, & Nahla Kamal Asaad. (2023). Serotonin, Endorphin Concentrations and Some Hematological Parameters in Male Narghile Smokers. Tikrit Journal of Pure Science, 23(6), 95–100. https://doi.org/10.25130/tjps.v23i6.678
Section
Articles

References

1- Amir AR, Behrad D, Afshin K, Yadollah SS, Amirreza R, and Siamak Y. Effect of Hubble-Bubble Smoking on Oral Health. Bull. Env. Pharmacol. Life Sci., 2014; 3(12): 52-59.

2- Aslam HM, Saleem S, German S and Qureshi WA. Harmful effects of shisha: literature review. International Archives of Medicine, 2014;7:16.

3- Saiem Al-Dahr MH. Impact of Smoking on Platelet, Coagulation and Lipid Profile in Young Male Subjects. World Applied Sciences Journal, 2010; 11(1): 118-123.

4- Fromme H and Schober W. Waterpipes and e-cigarettes: Impact of alternative smoking techniques on indoor air quality and health. Atmospheric Environment, 2014; 1-13.

5- Urkin J, Ochaion R and Peleg A. Hubble Bubble Equals Trouble: The Hazards of Water Pipe Smoking. The Scientific World Journal, 2006; 6: 1990–1997.

6- Gieringer DH. Marijuana Water Pipe and Vaporizer Study. Newsletter of the Mutidisciplinary Association for Psychedelic Studies (MAPS), 2000; 6(3):1–6.

7- Shihadeh A. and Saleh R. Polycyclic aromatic hydrocarbons, carbon monoxide, “tar”, and nicotine in the mainstream smoke aerosol of the narghile water pipe. Food Chem. Toxicol., 2005; 43(5):655–661.

8- Shafagoj YA, Mohammed FI, and Hadid KA. Hubble-bubble (water pipe) smoking: levels of nicotine and cotinine in plasma, saliva and urine. Int. J. Clin. Pharmacol. Ther., 2002; 40(6):249–255.

9- Jørgensen HS. Studies on the neuroendocrine role of serotonin. Dan Med Bull, 2007;54:266-88.

10- Harenberg J, Huhle G, Giese Ch, et al. Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopeni. British Journal of Hematology, 2000;109:182-186.

11- Malone KM, Waternaux C, Haas GL, Cooper TB, Li S, and Mann JJ. Cigarette Smoking, Suicidal Behavior, and Serotonin Function in Major Psychiatric Disorders. Am J Psychiatry, 2003; 160: 773–779.

12-Arbol JL, MunÄoz JR, Ojeda L, et al. Plasma concentrations of beta-endorphin in smokers who consume different numbers of cigarettes per day. Pharmacology, Biochemistry and Behavior, 2000; 67: 25 – 28.

13-Alsalhen KS, and Abdalsalam RD. Effect of cigarette smoking on liver functions: a comparative study conducted among smokers and non-smokers male in El-beida City, Libya. International Current Pharmaceutical Journal, 2014; 3(7): 291-295.

14-Kremer I, Bachner - Melman R, Reshef A, et al. Association of the Serotonin Transporter Gene With Smoking Behavior. Am J Psychiatry, 2005; 162(5): 924–930.