A Comparative Study of the effect of aqueous extract of Vitex agnus-castus plant on male and female’s liver’s enzymes of mice exposed to oxidative stress
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Abstract
This study was conducted to determine the Protective effect of aqueous extracts of Vitex agnus castus plant both doses, Normal active does(50mg/kg) and double (100mg/kg) in the liver enzymes and comported the deferent effect of it between the male and female’s of Mice, that exposed to oxidative stress induced by hydrogen peroxide (0.5%) with drinking water for (30) days, there were distributed into 10 groups which are (control group, H2O2 group, active dose of aqueous extracts of Vitex group, active dose of aqueous extracts of Vitex + H2O2, active dose of aqueous extracts of Vitex + H2O2 + vitamin E, active dose of aqueous extracts of Vitex+ vitamin E, double dose of aqueous extracts of Vitex, double dose of aqueous extracts of Vitex+H2O2, double dose of aqueous extracts of Vitex+H2O2+vitamin E, vitamin E + H2O2 .
The results showed that hydrogen peroxide led to a significant increase (p≤0.01) in ALT, AST and ALP levels, compared with the control group, and no significant effect were showed in the hydrogen peroxide between both male and female’s, The treating with aqueous extracts of the Vitex plant (50 &100 mg/kg) with H2O2 led to a significant decrease in ALT, AST and ALP levels in compare with infected control group , The treatment with Vitamin E and H2O2 led to a significant decrease in ALT, AST and ALP levels in compare with infected control group , It was concluded from the current study, the important role of aqueous extracts of the Vitex and vitamin E as an antioxidant through its important role in curbing the harmful effects of certain types of free radicals within the body and thus repair the damage done in changes of the mices liver enzyme over exposure to oxidative stress induced by hydrogen peroxide (H2O2. (
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