Relationship between Parathyroid hormone and some electrolytes in patients with End-Stage Renal Disease
Article Sidebar
Main Article Content
Abstract
parathyroid hormone (PTH) is the main regulator for homeostasis some electrolytes and blood albumin, although the roles of vitamin D3 in the homeostasis of calcium in the bone are well known, However, recent data indicate the existence of the role of vitamin D3 in the Non-bony tissue is through its effect on cell proliferation, differentiation and apoptosis. The vitamin D3 receptor and enzyme 1α-Hydroxylase necessary for the transformation of 25(OH)D3 to 1,25(OH)2D3 and the latter has been disclosed in several tissues, So the 25(OH)D3 may convert into an effective biological status of Paracrine effects and impact on the levels of vitamin D3 in the serum .
The aim of the present study :
- evaluate the strength of the link between the PTH levels and some electrolytes in the blood serum of patients with end stage renal disease (ESRD).
- evaluate the strength of the link between the vitamin D3 levels and some electrolytes in the blood serum of patients with ESRD.
- Identify the natural values of this system, and the changes occurring because of ESRD disease.
Collect samples from venous blood of disease ESRD under Hemodialysis (HD) 106 (60 males, 46 female) patients, and reviewers to the Ibn Sina Centre for dialysis / Baquba teaching Hospital, compared with 48 (32 males 16 females ) blood samples of healthy, with a record age, weight, sex, systolic blood pressure and diastolic blood pressure.
Underwent venous blood samples centrifuge speeds of 4000 r / min for 10 minutes, the serum was separated to perform the following analyzes :-
Measure the level of calcium, phosphate, PTH hormone and vitamin D3 .
The results of the current study:
Increase in the levels of PTH in patients ESRD compared with healthy .
Is not affected the levels of vitamin D3 in the blood serum of patients ESRD significant compared to healthy.
Decrease the levels of calcium in patiets ESRD compared with healthy.
Increase in the levels of phosphate patients ESRD compared to the healthy.
Moreover, study results indicated :
A positive correlation between PTH and phosphate in patients ESRD.
A negative correlation between PTH and calcium, vitamin D3 in patients ESRD.
A positive correlation between vitamin D3 and calcium, phosphate, in patients ESRD
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1- Roluleau, M.F. ; Warshawsky, H. ; Goltzman, D. (1986) . Parathyroid hormone binding in vitro to renal, hepatic, and skeletal tissues of the rat using a radioautographic approach. Endocrinology., 118:919-931 .
2- Segre, G.V.; D΄Amour, P.; Potts, J.T. Jr. (1976) . Metabolism of radioiodinated bovine parathyroid hormone in the rat. Endocrinology ., 99:1645-1652 .
3- Manya, H.; Akasaka-Manya, K.; Endo, T. (2010). "Klotho protein deficiency and aging". Geriatr Gerontol Int 10 (Suppl 1): S80–7.
4- Norman ; Anthony, W. (1998) . Sunlight, season, skin pigmentation, vitamin D, and 25-hydroxyvitamin D:integral components of the vitamin D endocrine system. Am J Clin Nutr ., 67:1108-10 .
5- Mac Laughlin, J.A.; Snderson, R.R.; Holick, M.F. (1982). Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin . Science28 ., 216 (4549) :1001-3 .
6- Silver, J.; Russell, J.; Sherwood, L.M. (1985). Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in
isolated bovine parathyroid cells. Proc Natl Acad Sci USA ., 82:4270-4273 .
7- Tietz, N.W; Burtis, C.A.; Ashwood, E.R. (1986). Textbook of Clinical Chemistry. W.B. Saunders Company, 112ailure112phia . 2nd ed ., p: 286-343.
8- Dennis, L.; Anthony, S.; Dan, L.; et al. (2005). Harrison΄s principles of internal medicine. 16th ed., 1645-1653.
9- National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification . (2002) .Am J Kidney Dis ., 39(2 Suppl 1):S1-266 .
10- Henry R ed. Clinical Chemistry: Principles and Technics, 2nd ed. New York, NY: Harper & Row 1974;723.
11- Burtis, C.A; Ashwood, E.R ; Bruns, D.E; eds. Tietz Fundamentals of Clinical Chemistry, 6th ed.St. Louis (MO): Saunders Elsevier (2008):715.
12- 5,000 Parathyroid Operation Without Frozen Section or PTH assays: measuring individual parathyroid gland hormone production in real time. (2009). Annals of Surgical Oncology, 3 : 656-666 .
13- Turpeinen, U.; Hohenthal, U.; Stenman, U.; Hakan. (2003). Determination of 25-hydroxyvitamin D in serum by HPLC and immunoassay. ClinChem., 49:1521-4 .
14- Abdelgader, N.I.; Abdrabo, A.A. (2013). Serum Calcium, Phosphorous, and Parathyroid Hormone in Sudanese Patients under Regular Haemodialysis. American Journal of Research Communication., 12: 353-359 .
15- Nicki, R.; Brian, R.; Stuart, H. (2010). Davidson's principles and practice of medicine . 21st edition. Churchill Livingston : 420-520 .
16- AL-Hisnawi, R.A.A.A.; Salih, H. (2014). A study of some biochemical changes in patients with chronic renal failure undergoing hemodialysis. Original Research Article. Int. J. Curr. Microbiol. App. Sci., 5: 581-586 .
17- Warade, J.P.; Kavitha, R. (2015). Secondary hyperparathyroidism in chronic kidney disease. Original Research Article. International Archives of Integrated Medicine ., 7 : 42-48 .
18- Silver, J.; Kilav, R.; Naveh-Many, T. (2002). Mechanisms of secondary hyperparathyroidism . Am J Physiol Renal Physiol ., 283(3): 67-76.
19- Goodman, W.G. (2003). Medical management of secondary hyperparathyroidism in chronic renal failure. Nephrol Dial Transplant ., 3:iii2-8.
20- Cockwell, P. (2015). Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD). Renal Med. Understanding Renal Disease .
21- Mehrotra, R.; Kermah, D.; Budoff, M.; Salusky, I.B.; Mao, S.S.; Gao YL et al. (2008) Hypovitaminosis D in chronic kidney disease. Clin J Am Soc Nephrol ., 3:1144-51.
22- Holden, R.M.; Morton, A.R.; Garland, J.S.; Pavlov, A.; Day, A.G.; Booth, S.L. (2010). Vitamins K and D status in stages 3-5 chronic kidney disease. Clin J Am Soc Nephrol., 5:590-7.
23- Marwaha, R.K.; Tandon, N.; Reddy, D.R.H.K.; Aggarwal, R.; Singh, R.; Sawhney, R.C. et al. (2005). Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am J Clin Nutr., 82:477-82 .
24- González, E.A.; Sachdeva, A.; Oliver, D.A.; Martin, K.J. (2004). Vitamin D insufficiency and deficiency in chronic kidney disease . A singlecenter observational study. Am J Nephrol ., 24:503-10 .
25- Levin, A.; Bakris, G.L.; Molitch, M.; Smulders, M.; Tian, J.; Williams, L.A. et al. (2007) . Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int ., 71:31-8
26- Ketteler, M.; Petermann, A.T. (2011). Phosphate and FGF 23 in early CKD: On how to tackle an invisible foe. Nephrol Dial Transplant., 26: 2430-2432.
27- Rozita, M.; Afidza, M.N.; Ruslinda, M.; Cader, R.; Halim, A.G.; Kong, C.T.N.; Azmi, K.N.; Shah, S.A. (2013). serum vitamin d levels in patients with chronic kidney disease. Original article. EXCLI Journal., 12: 511-520 .
28- Drueke, T.B. (2000). Cell biology of parathyroid gland hyperplasia in chronic renal failure. J Am Soc Nephrol., 11(6): 1141-52.
29- Friedman, E.A. (2005). Consequences and management of hyperphosphatemia in patients with renal insufficiency. Kidney Int Suppl., 95:1-7.