Biohistological study of the effect of isolated flavonoids from Brassica Olearacea var. Capitata in the effectiveness of (AST,ALT) and liver tissue structure in alloxan induced diabetic white rats females.
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Abstract
The study was designed to recognize the effects of flavonoids isolated from a Brassica oleracea plant to minimize the damage caused by diabetes induced by alloxan in the histological structure of liver and the levels of the (AST,ALT) in liver congeneric.
Fifteen female albino rats were used and divided into three groups equal: First group: control animals were given water and food, Second group: animals treated by alloxan, Third group: treatmed by alloxan and flavonol in peritoneal injection.
At the end of experiment all animals were sacrified and dissected to obtain the liver and Two grams was cut to measure the effectiveness of liver enzymes (AST,ALT), the remaining samples were prepared for histological sections and examination.
The results clarified: A significant decrease (p≤o.o5) in the levels of (AST,ALT) in the liver of G2 when compared with the G, There are a significant increase in the levels of (ALT,AST) in liver of G3 when compared with G2, Histological examination showed occurrence of degenerative changes in histological structures of the rats liver of G2, and infiltration of composition in rats liver of G3 approached natural form for the installation of G1rats livers.
conclude from this study that diabetes effect the effectiveness of enzymes levels (AST, ALT) in the liver and the degenerative changes in the structure of liver, and that the flavonol extracted from Brassica Olearacea var. Capitata has a treated effect of the damage caused by diabetes.
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