Histological study to the effect of Potassium Dichromate on the reproductive organs in mature rats
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Abstract
This study was designed to show the effect of potassium dichromate (24 mg/kg orally for 60 day) in mature male and female. The results of experiment in male rats showed decrease in seminiferous epithelia thickness and number of stage VII cells (spermatogonium, spermatocytes, spermatids) at the same time the experiment of immature female rats treated with potassium dichromate showed increase in the diameter of ovarian follicles in the categories (101-200), (201-300) and (<400) .It was concluded that potassium dichromate has detrimental effects on living tissue and in some sexual parts in both sexes (male and female) .
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References
1- Greenberg, M.I. (2003). Occupational, Industrial and Environmental Toxicology. 2nd ed. Mosby an affiliate of Elsevier science. pp.135-139.
2- Harrison, R.M. (1996).Pollution .Causes ,Effects and Control. 3rd ed .The Royal Society of chemistry. pp.418-419.
3- Bonde, J.P. (2002).Occupational risk to male reproduction. G Ital Lav Erg. 112-117.
4- Agarwal, A. and Gupta, S. and Sharma, R.K. (2005). Role of oxidative stress in female
reproduction. Reprod. Biol. Endocrinol. 3:3-28.
5- Sugiyama, M. (1992).Role of physiological antioxidant in Cr (v1) induced cellular injury. Free Rad. Biol. Med. 12:397-407.
6- Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M. and Mazur, M. ( 2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160:1–40. Cited by (Banu, S.K; Samuel, J.B; Arosh, J.A; Burghardt, R.C and Aruldas, M.M. (2008). Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroid genesis and pituitary synthesis in developing Wister rats. Toxic. Appl. Pharm. 232:180-189.
7- Kumar,S.; Sathwara, N.G.; Gautam, A.K.; Agarwal, K.; Shah, B.; Kul Karmi, P.K.; Patel., K.; Patel, A.; Dave, L.M.; Parikh, D.J. and Saiyed, H.N.(2005).Semen quality of industrial workers occupationally exposed to chromium .J. Occup. Health. 47:424-430.
8- Shmitova, L.A. (1990). Contents of hexavalent chromium in biological substrates of pregnant and puerperant women working in production of chromium compounds. Gig. Tr. Prof. Zabol. 2:33-35.
9- Bonde, J.P. (1993).The risk of male sub fecundity attributable to welding Studies of: Childhood malignancy, pregnancy outcome, semen quality and adverse infertility. Int. J. Androl. 16: 22-29.
10- Acharya, U.R.; Mishra, M.; Mishra, I. and Tripathy, R.R.(2004).Potential role of vitamins in chromium induced spermatogenesis in swiss mice. Environ. Toxicol. Pharmacol. 15:53-59.
11- Saxena, D.K.; Murthy, R.G.; Lal, B.; Srivastava, R.S. and Chandra, S. (1990). Effect of hexavalent chromium on testicular maturation in the rat. Reprod. Toxicol. 4:223-228.
12- Ernst, E. and Bond, J.P. (1991). Sex hormones and epididymal sperm parameters in rats following subchronic treatment with hexavalent chromium. Ltum. Exp. Toxicol. 11:255-258.
13- Wei, S.M.; Yan, Z.Z. and Zhou, J. (2008). Curcumin attenuates ischemia –reperfusion injury in rat testes. Fertil. Steril, Amer. Soc. Rep. Med.
14- Jana, K.; Jana, S. and Samanta, P.K. (2006). Effect of chronic exposure to sodium arsenate on hypothalamo-pituitary-testicular activities in adult rats: possible estrogenic mode of action. Rep. Bio. And Endo.9:1-13.
15- Aruldhas, M.M.; Subramanian, S.; Sekar, P.; Vengatesh, G.; Chandrahasan, G.; Govindarajulu, P.and Akbarsha, M.A. (2005). Chronic chromium exposure induced changes in testicular histoarchitecture are associated with oxidative stress. Study in a non-human primate (Macaca radiata Geoffroy). Hum.Reprod. 20 : 2801– 2813.
16- Sikka, S.C. (1996). Oxidative stress and role of antioxidants in normal and abnormal sperm function . Front . Biosic . 1:78-86 .
17- Banu, S.K; Samuel, J.B; Arosh, J.A; Burghardt, R.C and Aruldas, M.M.(2008).Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroid genesis and pituitary synthesis in developing Wister rats. Toxicology and Applied Pharmacology. 232:180-189.