Study the level of lipid oxidation in patients with coronary atherosclerosis
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Abstract
Introduction: The coronary heart disease CHD one of the most common diseases of the heart and blood vessels, especially in adults who ranged from age (40 years and above), it is known that the oxidative damage caused adverse effects on the cellular functions, leading to a number of disease states. The free radical, especially Reactive oxygen species (ROS) were playing an important role causing a lot of clinical cases including coronary heart disease. It was measuring some indicators of oxidation and anti-oxidants necessary to determine the relationship between these standards and their impact on the negative and positive CHD.
The number of patients included (60) samples for both sexes (30 males and 30 females), aged (40-69 years). They are non-smokers and do not drink alcohol. Without other diseases such as high blood pressure or diabetes, and healthy samples included (30) samples (15 males, 15 females), aged (40-67 years). The blood samples were collected from Kirkuk hospital.
Results: The results showed a significant decrease in probability (P≤0.05) in the levels of concentrations (TAC, SOD, VE, HDL) in patients with coronary heart disease and the results were (216.19±4.85µmol/L, 40.038±7.245 U/mL, 26.136±6.376umol/L, 29.128±2.001mg/dL) respectively, compared with the healthy group (422.66±69.11µmol/L, 72.191±2.729 U/mL, 39.251±7.839 umol/L, 56.267±8.890 mg/dL) respectively. While the concentrations of levels of (OxLDL, TC, TG) increased significantly high at (P≤0.05) in patients with CHD and the results were (283.97±28.75 pg/mL, 242.18±22.41 mg/dL, 274.14±56.35 mg/dL) respectively compared with the healthy group (138.56±15.04 pg/mL, 167.12±14.06 mg/dL, 108.97±12.30 mg/dL) respectively. And the current study showed that the sex statistically effect clear at (P≤0.05) between male and female patients compared with the healthy group, The role of age was evident also gave significant differences at (P≤0.05) for all age groups that have been studied and the increased risk of CHD with age in both sexes in patients compared with healthy group. The study also showed statistical differences at (P≤0.05) with increasing body mass index (BMI) when measuring all parameters for patients compared to healthy group.
Conclusion: The decrease in the levels of antioxidants (TAC, SOD, VE) and good cholesterol HDL versus an increase in oxidation OxLDL and lipids blood TC and TG as factors indicators cause increased oxidative stress in the blood serum of patients CHD as a result free radicals that put out the role of antioxidants and increased risk of disease CHD.
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