Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity
Article Sidebar
Main Article Content
Abstract
This study includs the synthesis of some new Amic acid and Imides,
starting from the esters [S1] of Terephthalic acid which then converted to
its hydrazide [S2] then to amic acid derivatives [S3-S7] and finally with
imides [S8-S12]. Preparing of ester [S1] by usual esterification of
terephthalic acid with absolute ethanol in acidic medium, then has
converted to its hydrazide [S2] by reacting it with hydrazine hydrate. The
amic acid derivatives [S3-S7] have been synthesized by the reaction of
hydrazide [S2] with anhydrides (2,3-dimethyl malic anhydride, 3-nitro
phthalic anhydride, hexahydro phthalic anhydride, Diphenic anhydride,
tetra Phenyl phthalic anhydride) in diethyl ether. Imides [S8-S12] were
also synthesized by cyclization of amic acids derivatives using acetic
acid anhydride and anhydrous sodium acetate. The synthesized
compounds were identified by spectral methods UV, FT-IR and H1-
NMR beside melting point and the purity was determined using (TLC)
and some of its physical properties were measured. Some of these
compounds were tested against four strains of bacteria (E. coli, P.
ariginosa, S. aurous and S. pyogenes)
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
[1] Nugent, W.A. and Mayer, J.M. (1988). Metal-Ligand Multiple Bonds, J. Wiley: New York.
[2] Hiran, B.L.; Boriwal, R.; Bapana, S. and paliwal, S.N. (2010). Jaurnal of University of Chemical Technology and Metallurgy, 45(2): 127pp.
[3] Kratz, F.; Mueller-Driver, R.; Hofmann, I.; Drevs, J. and Unger, C. (2000). Journal Med. Chemistry, 43: 1253pp.
[4] Kratz, F. (2002). Journal Med. Chemistry, 45: 5523pp.
[5] Warneck, A. and Kratz, F. (2003). Biocongate Chemistry, 14: 377pp.
[6] Vogel, I.A. (1974). Tex Book of practical organic chemistry" 3rd edn., Longman Group Ltd. London 781,395.
[7] Al-nima, H.H.; Al-dulami, J.R. and Hashim, O.K. (1986). Journal Iraqi Chemistry Soc., 11(1): 13pp.
[8] Hamad, A.S. (1997). Iraqi Journal Sci., 38(2).
[9] T.M. and Hamad, A.S. (1996). Poly. Journal, (23): 5282pp.
[10] Olcay, B.; Bahsttin, K. and Murat, K. (2006) Turk. Journal Chemistry, 30(2).
[11] Garrol, L.; lambert, H.; Grady, D. and Worth, P. (1981). Antibiotic and Chemotherapy 5th edn., Churchill Livingstone New York.
[12] Bauer, A.W.; Kirby, W.A.M.; Sherries, J.S. and Turk, M. (1966). Amer. Journal Clin. Patho.