Protective role of CoQ10 in reducing the side effects resulting from the use of Tramadol on some immunological variables in the endemic female rabbits
Article Sidebar
Main Article Content
Abstract
The aim of study to determine out the role of CoQ10 in reducing the side effects from the use of Tramadol on the level of Interlukin IL-6, IL-10 and PGF2α the study included 30 endemic female rabbits, where each group included 5 animals. The results showed increase with a highly significant with (P≤0.01) in the concentration of IL-10 in sera of treated group with tramadol (initial dose) and group treated tramadol (double dose) group treated tramadol (initial dose + CoQ10) and group treated with tramadol (double dose + CoQ10) compare with control.
The results showed no significant differences in the concentration of IL-10 in sera of treated group with Co Q10 compare with control. The results revealed high significant increase (P≤0.01) in the concentration of IL-6 in the sera of the treated group with tramadol (double dose) group treated with tramadol (initial dose + COQ10) as compared with the control and the results showed the presence of high significant decrease (P≤0.01) in the concentration of IL-6 in the sera of the group treated with tramadol (initial dose) and treated with group tramadol (double dose + COQ10) compare with control. the results showed there were no significant differences in the concentration of IL-6 in serum of group treated with CoQ10 as compare with control. Results indicated occurrence of high significant increase (P≤0.01) in a concentration of PGF 2α in serum of the group treated with tramadol (initial dose) and group treated with tramadol (double dose)and group treated with tramadol (initial dose + CoQ10) and group treated with tramadol (double dose +CoQ10) compare with control. The results showed presence of a highly significant decrease (P≤0.01) in the concentration of P G F 2α in sera of group treated with CoQ10 as compare with control.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1- Giuliano, F. A. (2007) .novel treatment of premature ejaculation. Eur Urol Suppl;6:780–6.
2- Samman, s and Darnton-Hill, I. (2015). Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus j. healthcare., 3, 296-309.
3- Bentov, Y.; Hannam, T.; Jurisicova, A; Esfandiari, N; Casper, R. F .(2014). Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF–ICSI Treatment. J. Clin Med Insights Reprod Health 8: 31-36.
4- Safarinejad, M. R. (2012). “The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study,” International Urology and Nephrology., 44(3): 689–700,.
6- Sharma, L.; Dhaliwal, L.; Saha, S.; Sangwan, S.; and Dhawan,v.(2010(.
7- Steel, R.G.D. and Torries, J.H. (1980). Principle and Procedures of Statistics: A Biochemical Approach. 2nd edition, McGraw-Hill Book Company Inc., New York, USA.
8- Schneider, C.; Schwacha, M.;and Chaudry, I.(2004). The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhag. Biochim Biophys Acts, 1689(1): 22- 32.
9- Saraiva, M. O and Garra, A. (2012). The regulation of IL-10 production by immune cells. Immunology,10:1038-2711
10- Enoch, B. and Ashley, T. (2013).Interleukin 10 (IL-10) regulation cytokine and its clinical consequences. Clin & Cell Immunology, (10):170-182.
12- Garcia, Z.; Rojas, L.; Esquivel, V.; and Ostoa,S. (2007). Regulation of the inflammatory immune response by the cytokine/ chemokine network in amoebiasis. Parasite Immunol. Articale Dol : 10: 136-148
13- Cary, SAS. (2010). Statistical Analysis System, User's Guide. Statistical. Version 7th ed. SAS. Inst. Inc. Cary. N.C. USA .
14- Shinjiro, H.; Amon, A.; Suzanne, E.; Thomas, A.; Edward, H.; and Eric, H. (2006).Resistance of C57BL/6 mice to Amoebiasis is Mediated by nonhemopoietic cell but requires hemopoietic IL-10 production .American Association of Immunologists, 177: 1208-1213.
15- Jayapal, V. (2007). Cytokines. In: Fundamental of Medical Immunology. 6th Ed. Jaypee Brothers Medical Publishers . LTD.: 122 – 135.
16- Tjiong, M. Y.; Van-Der-Vange, N.; Ten-Kate, F. J.; Tjong-A-Hung, S. P.; ter Schegget, J.;
Burger, M. P. and Out, T. A. (1999). Increased IL-6 and IL-8 levels in cervicovaginal. secretions of patients with cervical cancer . Gynecologic Oncology Journal ., 73(2):285-291 .
17- Koçak, I. ; Yenisey, Ç. ; Dünder, M. ; Okyay, P. and Serter, M. (2002). Relationship between seminal plasma interleukin-6 and tumer necrosis factor α levels with semen parameters in fertile and infertile men . Urol. Res. 30:263-267 . 18- Kraychete, D.C.; Sakata, R.K.; Issy, A.M; Bacellar, O.; Jesus R.S.; Carvalho, E.M. (2009). Proinflammatory cytokines in patients with neuropathic pain treated with Tramadol. J. National Institutes of Health., 59(3):297-303.
19- Villaran, C. O.; Neill, S.J and Helbling, A. (1999). Montelukast versus salmeterol in patients with 1999) asthma and exercise - induced bronchoconstriction. J. Allergy Clin. Immunol.; 104: 547.
20- Adkinson, N.F.;Yunginer, J.W.; Busse, W.W; Bochner, B.S; Holgate, S.T and Simons F.R. (2003). Middleton’s Allergy Principles and Practice, 6th ed. Vol 1. Philadelphia, Mosby Inc Company.: 213-230.
21- Pfitzer, G .(2001). Invited review: regulation of myosin phosphorylation in smooth muscle. J. Appl. Physiol.,91: 497-503.
22- Somlyo, A.P; Somlyo, A.V. (2003). Ca2+ sensitivity of smooth muscle and nonmuscle myosin ll: Modulated by G proteins, Kinases, and myosin phosphatase. Physiol. Rev.; 83: 1325-1358.
23- Schaafsma, D.; Bos, I.S.T.; Zuidhof, A.B.; Zaaysma, J and Mears, H.(2006). Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen- induced airway hyperresponsiveness after the early and late asthmatic reaction. Respir Res.; 7:121.
24- Ganong, W.F. (2004). Review of Medical Physiology. 21st ed. Beirut, Mc Graw-Hill Publish.: 40, 311-313.
25- Beasley, C.R; Robinson, C; Featherstone, R.L.; Varley, J.G.; Hardy, C.C.; Church, M.K and Holgate, S.T. (1987). 9 alpha, 11 beta- prostaglandin F2 , Novel Metabolite of prostaglandin D2 is a potent contractive agonist of human and guinea pig airway. J. Clin. Invest.; 79(3): 978-983.
26- Helmersson, J. (2005). Prostaglandins and Isoprostanes in relation to risk factors for atherosclerosis, role of inflammation and oxidative stress. Acta Universitatis Upsaliensis for Ph-D. Degree in Faculty of Medicine;.
27- Débora, C. D.; Gustavo, T. V.; Cássio F.; Luciana, B. R. and Maricelmada, S. S. (2008). Effect of Indomethacin on the Pregnant Rat. Braz. arch. biol. technol. , 51(.1): 75-81.