Effect of using Melatonin in reducing the heart toxicity produced from the use of Doxorubicin drug on some hormones in the experimental male rabbits
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Abstract
This study amid to search the role of Melatonin in reducing the heart toxicity and atherosclerosis which result from using of Doxorubicin in treatment of cancer Also the role of hydrogen peroxide in inducing oxidative stress in Laboratory Albino rabbit; Growth Hormone and (T3,T4,TSH) levels. the Study included 40 male rabbits, where each group consist of 5 animals. the study showed high Significant decrease in Growth Hormone concentration (P≤0.01) in Dox group (15mg/kg of.w) and group of animals treated with H2O2 alone while the concentrations of Growth Hormone had been increase with high significant (P≤0.01) in other groups. The results showed high significant (P≤0.01) in the hormone (T4) concentration in serum in the group H2O2 and Dox group alone compare with control and the occurrence of a highly significant increase (P≤0.01)of Hormone (T3) (T4) concentrations in Animal group treated with Dox (15 mg/kg) and Melatonin Also group treated with H2O2 and Melatonin, and group treated with Cholesterol and Melatonin. while high significant decrease (P≤0.01) had been happened in Hormone (T3) (T4) concentration in sera of other groups of animals compared with the control. and the results showed high significant (P≤0.01) in the hormone TSH concentration in serum in the group Dox and Cholesterol group alone compare with control. there were no significant differences in the concentration of the hormone TSH in the group H2O2 alone and the other groups compared with the control.
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References
1-Lerner, A.; Case, J.; Rakahashi, Y. and. Lee, T. (1958). J. Am.Chem. Soc. 80:2587.
2- Espino J, Bejarano I, Sergio D. Paredes, Carmen Barriga, Ana B. Rodríguez and José A. Pariente. (2011). Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. Journal of Pineal Research. 51, 2,195–206.
3- Ogawa, T.; Higashi, S.; kawarada, Y.; and Mizumoto, R.(1995). Role of reactive oxygen in synthetic estrogen induction of hepatocellular carcinomas in rats and Preventive effect of Vitamins . Carcinogenesis, 16 : 831-836 .
4- Ottonello, S.; Foroni, C.; Carta, A.; Petrucco, S.; and Maraini, G.(2000). Oxidative stress and age-related cataract .Ophthalmology. 214: 78-85 .
5- Wendland, B.; Aghdassi, E.; Tam C.; Carrier, J.; Steinhart, A.; Wolman, S.; Baron, D. and Allard, J. (2001).Lipid peroxidation and plasma antioxidant micronutrients in crohndisease. Am. J. Clin. Nutr., 74:259-264.
6- Craig, C. and Stitzel, R.(1982) Modern Pharmacology, (1sted) Ch56 745-789,http:/www.link. Sparinger. de/search.htm.
7- Kojima M, Hosoda H, Date Y,.(1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature;402:656-660.
8- Eaton, J. and Qian, M.(2002). Free Rad. Biol. Med, 32, 833-840.
9- Yagmurca M, Bas O, Mollaoglu H, Sahin O, Nacar A, Karaman O, Songur A (2007) Protective effects of erdosteine on doxorubicin – induced hepatotoxicity in rats .Arch Med Res ,38(4):380-385.
10- Han D, Loukianoff S, McLaughlin L (2010). Oxidative stress indices: analytical aspects and significance. In: Sen CK, Packer L, Hanninen O (eds) Handbook of oxidants and antioxidants in exercise. Elsevier, New York, pp 43 3-484 .
11- Flynn, N. E., Meininger, C. J., Haynes, T. E. and Wu, G. (2002). The metabolic basis of arginine nutrition andpharmacotherapy. Biomedicine & Pharma cotherapy; 56: 427-438.
12- Rudling, M.; Oarini, P. &Angelin, B. (1997). Growth hormone and bile acid synthesis. Keyrole for the activity of hepatic microsoma cholesterol 7a-hydroxylase in the rot. J. Clin. Invest., 99:2239-2245.
13- Kedari, G. S. R. (2011). Evaluation of the Thyroid Status, Oxidant Stress and Antioxidant Status in patients with Type-2 Diabetes Mellitus. India Journal of Clinical and Diagnostic Research. 5(2):254- 256 -255.
14- Woeber, K.A. 2000). Update on the management of hyperthyroidism and hypothyroidism. Arch Fam Med; 9: 43 - 747.
15- Asvold, B.O.; Vatten, L.J.; Nilsen, T.I.L.; Bjoro, T. (2007). The association between TSH within the reference range and serum lipid concentrations in a population-based study. Euro. J. Endocr., 156, 181-186.
16- Zhu, X.; Cheng, S.Y. (2010).New insights into regulation of lipid metabolism by thyroidhormone. Curr. Opin. Endocrinol. Diabetes Obes.,17 (5), 408-413.
17- Marseglia, L; Salvatore A, Ignazio B, Camelo, D, Salpietro D.S, Erika C, Antonio, S, Antonella. S, Camelo. R, and Eloisa G. (2013) .High Endogenous Melatonine level in critically ill children: A pilot study . The .J,of Pediatrics . 162, 2,pp:356-360.
18- Valentao, P., Fernandes, E., Carvalho, F., Andrade, P. B., Seabra, R. M. and Bastos, M. L., (2003)Phytomedicine., , 10 (6-7), 517. 19- Kozirog, M., A.R. Poliwczak, P. Duchnowicz, M. Koter-Michalak, J. Sikora and M. Broncel, (2011). Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J. Pineal Res., 50: 261-266.
20- Al-Rubae'i, S.H. N. and Al-Musawi, A.K. (2011). An evaluation of antioxidants and oxidative stress in Iraqi patients with thyroid gland dysfunction. African Journal of Biochemistry Research . 5(7), pp. 188-196.
21- Patidar, R.K.; Raghuwanshi, R.; Sharma, P.; Singh, V. (2012). An associative investigationbetween TSH and serum lipid concentrations in the population of Bhopal, India. IJPSR. ,3 (4),1112-1115.
22- Chandra, A.K., mukhopadyay, S., Lahari, D. and Tripathy, S.(2004). Giotrogenic content of Indian cyanogenic plant foods and their in vitro anti–thyroidal activity. Indian J. Med Res; 119: 180–185.
23- Abdelatif, A. M. and Saeed, I. H.(2009). Effect of Altered Thyroid Status in the Domestic Rabbit (Lepuscuniculus) on Thermoregulation, Heart Rate and Immune Responses. Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum, Sudan, P.O. Box 32, Khartoum North, Sudan Department of Physiology, College of Veterinary Science, University of Bahr El-Ghazal, Sudan. Global ,Veterinaria 3 (6): 447-456.
24- Meier, C., Staub, J., Roth, C., Guglielmetti, M., Kunz, M., Miserez, A. R., Drewe, J., Huber, P., Herzog, R., and Müller, B. (2001) TSH-Controlled L-Thyroxine Therapy Reduces Cholesterol Levels and Clinical Symptoms in Subclinical Hypothyroidism: A Double Blind, Placebo-Controlled Trial (Basel Thyroid Study). The Journal of Clinical Endocrinology & Metabolism. 86, 10: 4860-4866.
25- Auer, J.; Berent, R.; Weber, T.; Lassing, E.; Eber, B. (2003). Thyroid function is associated with presence and severity of coronary atherosclerosis. Clin.Cardiol.,26: 569-573.
26- Peppa, M.; Betsi, G.; Dimitriadis, G. (2011). Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease. J. Lipids., 1-9.
27- Yun, K.H.; Jeong, M.H.; Oh, S.K.; Lee, E.M.; Lee, J.; Rhee, S.J.; Yoo, N.J.; Kim, N.H.;Ahn, Y.K.; Jeong, J.W. (2007). Relationship of thyroid stimulating hormone withcoronary atherosclerosis in angina patients. Int. J. Cardiol., 122 (1): 56-60.