Synthesis and Characterization of 1,2,3- Triazole Derivatives from D-Mannitol
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Abstract
This research included the use of azido D-Mannitol (3) to synthesize 1,2,3 triazole derivatives. Azido D – Mannitol (3) itself used as an intermediate which was prepared from reaction of 1, 2:5, 6-Di-o-isopropylidene-3,4-di-p-tosyl-D-Mannitol (2) with sodium azide. The prepared compound (3) was allowed to react with alkenes for the formation of corresponding 1,2,3 triazole (4a-e ).
The structures of some prepared compounds were confirmed by physical properties and spectroscopic methods FT-IR , 1H-NMR , 13C-NMR and Mass spectra in addition to use TLC.
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