Significance of total and specific IgE in asthma of Iraqi adult patients
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Abstract
A case-control retrospective study was conducted during January – June 2019 on 104 patients with asthma (50 females and 54 males) and 111 non-asthmatic healthy subjects matched patients for gender (54 females and 57 males) to assess role of total and specific IgE serum levels in patho-physiology of disease using ELISA and multiplex immunoblot kits. The mean age ± standard deviation of asthma patients was 37.9 ± 12.1 years, while it was lower among control (35.9 ± 10.5 years), but the difference was not significant. Males and females were similarly distributed among asthma cases (48.1 and 51.9%, respectively) and control (48.6 and 51.4%, respectively). Most of asthma cases were observed to have mild disease (49%), followed by moderate and severe asthma (93.4 and 11.5%, respectively). It was also observed that 51.9% of patients had a family history of asthma. With respect to allergen type, 21.2% of asthma cases were seropositive for mixed types of allergens. Median level of total IgE was significantly (p < 0.001(elevated in sera of asthma cases (204.1 ng/ml) compared to control subjects (163.3 ng/ml). The level positively paralleled the severity of disease. The highest level was observed in severe cases (244.9ng/ml, while the lowest level was recorded in mild cases (189.7 ng/ml). The level of specific IgE showed some variations among asthma cases distributed according to the type of allergen, the highest median was recorded in seronegative cases (215.2 ng/ml), while a lowest level was observed in cases seropositive for animal dander (189.3 ng/ml). Logistic regression analysis revealed that total asthma patients, as well as male and female cases were at an increased risk to develop asthma episodes due to elevated serum level of IgE.ROC analysis demonstrated that elevated serum level of IgE occupied a significant (p = 0.001) area under curve (AUC), which was 0.828. In conclusion, the present study confirms the significant role of total and specific IgE in patho-physiology of bronchial asthma and its correlation with disease severity and allergen type in adults
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References
[1] Castillo, J.R.; Peters, S.P. and Busse, W.W. (2017). Asthma exacerbations: pathogenesis, prevention, and treatment. Journal of Allergy and Clinical Immunology: In Practice, 5 (4): 918–927.
[2] Papi, A.; Brightling, C.; Pedersen, S.E.; et al. (2018). Asthma. The Lancet, 391 (10122): 783–800.
[3] Patel, T.R. and Sur, S. (2017). IgE and eosinophils as therapeutic targets in asthma. Current Opinion in Allergy and Clinical Immunology, 17 (1): 42–49.
[4] Platts-Mills, T.A.E.; Schuyler, A.J.; Erwin, E.A; et al. (2016). IgE in the diagnosis and treatment of allergic disease. Journal of Allergy and Clinical Immunology, 137 (6): 1662–1670.
[5] Navinés-Ferrer, A.; Serrano-Candelas, E.; Molina-Molina, G.J.; et al. (2016). IgE-related chronic diseases and anti-IgE-based treatments. Journal of Immunology Research, 2016 (2016).
[6] Anto, J.M.; Bousquet, J.; Akdis, M.; et al. (2017). Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. Journal of Allergy and Clinical Immunology, 139 (2): 388–399.
[7] Ayakannu, R.; Abdullah, N.A.; Radhakrishnan, A.K.; et al. (2019). Relationship between various cytokines implicated in asthma. Human Immunology, 80 (9): 755–763.
[8] Becker, A.B. and Abrams, E.M. (2017). Asthma guidelines: The global initiative for asthma in relation to national guidelines. Current Opinion in Allergy and Clinical Immunology, 17 (2): 99–103.
[9] Faul, F.; Erdfelder, E.; Lang, A.G.; et al. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. In: Behavior Research Methods, 39 (2): 175–191.
[10] Matucci, A.; Vultaggio, A.; Maggi, E.; et al. (2018). Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question? Respiratory Research, 19 (1): 113.
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[11] Ahmed, H. and Turner, S. (2019). Severe asthma in children—a review of definitions, epidemiology, and treatment options in 2019. Pediatric Pulmonology, 54 (6): 778–787.
[12] Barnthouse, M. and Jones, B.L. (2019). The impact of environmental chronic and toxic stress on asthma. Clinical Reviews in Allergy and Immunology, 57 (3): 427–438.
[13] Baldaçara, R.P. de C. and Silva, I. (2017). Association between asthma and female sex hormones. Sao Paulo Medical Journal, 135 (1): 4–14.
[14] Yung, J.A.; Fuseini, H. and Newcomb, D.C. (2018). Hormones, sex, and asthma. Annals of Allergy, Asthma and Immunology, 120 (5): 488–494.
[15] Shah, R. and Newcomb, D.C. (2018). Sex Bias in Asthma Prevalence and Pathogenesis. Frontiers in immunology, 9: 2997.
[16] Sandeep, T.; Roopakala, M.S.; Silvia, C.; et al. (2010). Evaluation of serum immunoglobulin e levels in bronchial asthma. Lung India, 27 (3): 138–140.
[17] Dávila, I.; Valero, A.; Lm, E.; et al. (2015). Relationship between serum total IgE and disease severity in patients with allergic asthma in Spain. Journal of Investigational Allergology and Clinical Immunology, 25 (2): 120–127.
[18] Borish, L.; Chipps, B.; Deniz, Y.; et al. (2005). Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Annals of Allergy, Asthma and Immunology, 95 (3): 247–253.
[19] Bao, Y.; Chen, Z.; Liu, E.; et al. (2017). Risk factors in preschool children for predicting asthma during the preschool age and the early school age: a systematic review and meta-analysis. Current Allergy and Asthma Reports, 17 (12): 85.
[20] Turki, S.G.; Ad’hiah, A.H.; Brakhas, SA.; et al. (2020) Allergen profile of rhinitis and asthma among Iraqi patients: Allergens in rhinitis and asthma. Clinical Epidemiology and Global Health, 8 (2): 637–642.