Study of Some Physiological and Biochemical Parameters in Women with Breastfeeding and Non-Breastfeeding in Erbil City
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Abstract
Blood samples from one hundred healthy women (29-33 year) have been taken. The women were divided into 2 groups: group 1 including 50 women that exclusively breast-fed for 6 months, and group 2 composed of 50 women in whom lactation was inhibited with formula feeding.
The two groups were comparable in lipid profile, random blood sugar, serum calcium and phosphors, tumor markers, and testosterone hormone (P-value < 0.01). Low density lipoprotein cholesterol (LDL-C) and random blood sugar (RBS) were significantly less in the breastfeeding group (P-value < 0.01). The mean totals LDL-C were 56.01± 0.35 and 71.90 ± 0.43mg/dl in groups 1 and 2, respectively. High-density lipoprotein cholesterol (HDL-C) was higher in the breastfeeding groups than in non-breastfeeding mothers (44.21±068mg/dl vs. 40.83±0.14mg/dl) but the difference was not statistically significant. Nevertheless, serum cholesterol, serum triglyceride, and serum very low density lipoprotein cholesterol (VLDL-C) were insignificantly lowers in breastfeeding group (95.37±1.02 mg/dl) in comparison to non-breastfeeding group (112.8±1.02 mg/ dl). Tumor marker were determined with chemiluminescent immunometric methods in each group via an automatic hormone analyzer. However, breastfeeding mothers have slightly less percentage of CA 15-3 and CA 125 than formula-feeding mothers (9.67 ± 0.071 U/ml and 9.79 ± 0.079 U/ml versus 12.84 ± 0.13 U/ml and 12.34 ± 0.14 U/ml, respectively), but the difference was not statistically significant.
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References
1. American Academy of Pediatrics Work Group on
Breastfeeding (1997). Breastfeeding and the use of
human milk. Pediatrics 100, 1035–1039.
2. Sadoh, A.E.1.; Sadoh, W.E. and Oniyelu, P.
(2011). Breast feeding practice among medical
women in Nigeria. Nigerian Medical Journal,
52(1):7-12.
3. Monasta, L.; Batty, G.D.; Cattaneo, A.; Lutje, V.;
Ronfani, L.; Van Lenthe, F.J. and Brug, J. (2010).
Early-life determinants of overweight and obesity: a
review of systematic reviews. Obesity Reviews,
11(10): 695-708.
4. WHO collaborative study team on the role of
breastfeeding on infant and child mortality due to
infectious disease in less developed countries a
pooled analysis. Lancet, 2000.
5. Motee, A. and Jeewon, R. (2014). Importance of
exclusive breastfeeding and complementary feeding
among infants. Current Research in Nutrition and
Food Science, 2(2).
6. Mazumder, M.S. and Hossain, M.K. (2012).
Duration of breastfeeding and its determinants in
Bangladesh. International Journal of Natural
Sciences, 2(2):49-53
7. Feldman, S. (2007). Nursing Through Pregnancy.
New Beginnings (La Leche League International), 17
(4): 116–118.
8. Holden, G.W. (2015). Parenting A dynamic
perspective. 2nd edition. Sage publication, inc. USA.
9. Chua, S.; Arulkumaran, S.; Lim, I.; Selamat, N.
and Ratnam, S. (1994). Influence of breastfeeding
and nipple stimulation on postpartum uterine activity.
British Journal of Obstetrics and Gynecology, 101 (9): 804–805.
10. Stuebe, A.M. and Rich-Edwards, J.W. (2009). The reset hypothesis: lactation and maternal metabolism. American Journal of Perinatology, 26(1): 81-88.
11. Lovelady, C.; Garner, K.; Moreno, K. and Williams, J. (2000). The effect of weight loss in overweight, lactating women on the growth of their infants. The New England Journal of Medicine, 342 (7): 449–453.
12. Cohen, R.J.; Brown, K.H.; Canahuati, J.; Rivera, L.L. and Dewey, K.G. (1994). Effects of age of introduction of complimentary foods on infant breast milk intake, total energy intake, and growth: a randomized intervention study in Honduras. Lancet, 344: 288-293.
13. Ip, S.; Chung, M.; Raman, G.; Chew, P.; Magula, N.; DeVine, D.; Trikalinos, T. and Lau, J. (2007). Breastfeeding and maternal and infant health outcomes in developed countries. Evidence report/technology assessment, April (153): 1–186.
14. Adab, P.; Jiang, C.Q.; Rankin, E.; Tsang, Y.W.; Lam, T.H.; Barlow, J.; Thomas, G.N.; Zhang, W.S. and Cheng, K.K. (2014). Breastfeeding practice, oral contraceptive use and risk of rheumatoid arthritis among Chinese women: the Guangzhou Biobank Cohort Study. Rheumatology, 53(5): 860-866.
15. Labbok, M.H. and Colie, C. (1992). Puerperium and breastfeeding. Current Opinion in Obstetrics and Gynecology, 4:818-825.
16. Kathleen Park Talaro, K.P. (2014). Foundations in Microbiology. 8th edition. Content technologies, Inc.
17. Devlin, T.M. (2006). Textbook of biochemistry with clinical correlations. 6th ED. Wiley-Liss. New York.
18. Guyton, A.C. and Hall, J.E. (1996). Textbook of medical physiology. 9th Ed. Saunders Company. Philadelphia.
19. Vander, A.; Sherman, J. and Luciano, D. (1998). Human physiology. The mechanism of body function. 7th Ed. Boston Massachusetts.
20. Champ, P.C. and Harvey, R.A. (1994). Lippincott illustrated reviews Biochemistry. 2th Ed. Lippincott Williams and Wilkins Awolters Kluwer Company. Philadelphia.
21. Edge, S.B. and Compton, C. (2010). The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM. Annals of Surgical Oncology, 17: 1471-1474.
22. Romieu, I.; Hernandez-Avila, M.; Lazcano, E.; Lopez, R. and Romero-Jaime, R. (1996). Breast Cancer and lactation history in Mexican women. American Journal of Epidemiology, 143:543-552.
23. Labbok, M.H. (2001). Effects of breastfeeding on the mother. Pediatric Clinics of North America, 48:143-158.
24. Chilvers, C. (1993). Breastfeeding and risk of breast cancer in young women: United Kingdom
National Case-Control Study Group. BMJ, 307:17-20.
25. Carlson, K.J.; Eisenstatm, S.A. and Ziporyn, T. (1996). The Harvard guide to women’s health. Harvard University Press. Cambridge.
26. Gwinn, M.L.; Lee, N.C.; Rhodes, P.H.; Layde, P.M. and Rubin, G.L. (1990). Pregnancy, breastfeeding and oral contraceptives and the risk of epithelial ovarian cancer. Journal of Clinical Epidemiology, 43: 559-568.
27. Kjos, S.L.; Henry, O.; Lee, R.M.; Buchanan, T.A. and Mishell, D.R. (1993). The effect of lactation on glucose and lipid metabolism in women with recent gestational diabetes. Obstetrics and Gynecology, 82:451-455.
28. Carlsen, S.M. (2010). Breastfeeding is not as beneficial as once thought. Norwegian University of Science and Technology, http://www.ntnu.edu/ news/breastfeeding
29. Rhoades, R.A. and Bell, D.R. (2009). Medical physiology, principles for clinical medicine. 3rd edition. Lippincott Williams and Wilkins. China
30. Kovacs, C.S. (2008). Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. American Journal of Clinical Nutrition, 88(2): 520S-528S.
31. Marshall, W.J. (1995). Clinical Chemistry. (3rd Ed.). London: Mosby.
32. Allan, C.; Deacon, P. and Dawson, J.G. (1979). Enzymic assay of total cholesterol involving chemical or enzymic hydrolysis--a comparison of methods. Clinical Chemistry, 25: 976-984.
33. Nauck, M.; Warnick, G.R. and Rifai, N. (2002). Methods for measurement of LDL-cholesterol: a critical assessment of direct measurement by homogeneous assays versus calculation. Clinical Chemistry, 48: 236-254.
34. Trinder, P. (1969). Determination of glucose in blood using glucose oxidease with an all ernative oxygen occeptor. Ann. Clin. Biochem., 6, 24-33.
35. Bielecka-Dabrowa, A.; Hannam, S.; Rysz, J. and Banach, M. (2011). Malignancy-associated dyslipidemia. The open cardiovas. Med. J., 5: 35-40.
36. Oyer, D. and Stone, N. (1989). Cholesterol levels and the breastfeeding mom. JAMA, 262: 2092.
37. Kramer, F.; Stunkard, A. and Marshall, K. (1993). Breastfeeding reduces maternal lower-body fat. J Am Diet Assoc, 93: 429.
38. Sadauskaite-Kuehne, V.; Ludvigsson, J.; Padaiga, Z.; Jasinskiene, E. and Samuelsson, U. (2004). Longer breastfeeding is an independent protective factor against development of type 1 diabetes mellitus in childhood. Diabetes Metabolism research and reviews, 20(2): 150-157.
39. Laskey, M.A. and Prentice, A. (1999). Bone mineral changes during and after lactation. Obstetrics and Gynecology, 94:608-15.
40. Chowdhury, R.; Sinha, B.; Sankar, M.J.; Taneja, S.; Bhandari, N.; Rollins, N.; Bahl, R. and Martines, J. (2015). Breastfeeding and maternal health
outcomes: a systematic review and meta-analysis. Acta Paediatrica, 104(467): 96.
41. Rosenblatt, K.A. and Thomas, D.B. (1993). Lactation and the Risk of Epithelial Ovarian Cancer. International Journal of Epidemiology, 22(2): 192-197.
42. Glaser, R.L.; Newman, M.; Parsons, M.; Zava, D. and Glaser-Garbrick, D. (2009). Safety of maternal testosterone therapy during breast feeding. International Journal of Pharmaceutical Compounding, 13 (4): 314-7.