The Study the Effect of Type and Duration of Treatment on Some Hematological and Biochemical Variables of Lymphoma Patients in Al-Muthanna Province, Iraq
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Abstract
The term "malignant lymphoma" describes primary cancers of the lymphoreticular system, almost all of which begin as lymphocytes. This study aimed to assess the impact of therapy type and duration on several hematological and biochemical parameters in lymphoma patients. The study was conducted from July 2023 to October 2023. This study examined one hundred samples in total, fifty sample as control group and fifty sample as patients group. The age range of the participants was between 5 and 77 years old. Some hematological and biochemical tests were analyzed in the current study. The study showed a significant increase (P<0.05) according to type and duration of therapy in patient groups. The study indicated a significant decrease (P<0.05) in red blood cells(RBC), hemoglobin (Hb), lymphocyte and basophils compared with control groups, but indicated a significant increase (P<0.05) in white blood cells (WBC), neutrophils and platelets compared with control groups. Also, the study showed a significant increase (P<0.05) in urea, creatinine, alanine aminotransferase(ALT) and aspartate transaminase (AST) compared with control groups.
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References
[1] Prusila, R. (2020). Clinical studies in adult lymphomas with special emphasis on late effects of treatments,762-773.
https://urn.fi/URN:ISBN:9789526225432.
[2] Alvarez-Lesmes, J., Chapman, J. R., Cassidy, D., Zhou, Y., Garcia-Buitrago, M., Montgomery, E. A., and Poveda, J. (2021). Gastrointestinal tract lymphomas: a review of the most commonly encountered lymphomas. Archives of Pathology & Laboratory Medicine, 145(12): 1585-1596.
https://doi.org/10.5858/arpa.2020-0661-RA
[3] Kurz, K. S., Kalmbach, S., Ott, M., Staiger, A. M., Ott, G., and Horn, H. (2023). Follicular Lymphoma in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Biological Data. Cancers, 15(3): 785.
[4] Coradduzza, D., Azara, E., Medici, S., Arru, C., Solinas, T., Madonia, M., ... & Carru, C. (2021). A preliminary study procedure for detection of polyamines in plasma samples as a potential diagnostic tool in prostate cancer. Journal of Chromatography B, 1162, 122468.
[5] Baumann, K. (2003). Cross-validation as the objective function for variable-selection techniques. TrAC Trends in Analytical Chemistry, 22(6): 395-406.
[6] Coradduzza, D., Ghironi, A., Azara, E., Culeddu, N., Cruciani, S., Zinellu, A.& Carru, C. (2022). Role of polyamines as biomarkers in lymphoma patients: A pilot study. Diagnostics, 12(9): 2151.
[7] Chen, H., Zhong, Q., Liu, Y., Li, J., Deng, W., Wang, J., and Xiao, L. (2023). A prospective single-arm study on the relationship between dose-volume parameters of pelvic functional bone marrow and acute hematological toxicities during intensity-modulated radiotherapy with or without concurrent chemotherapy for uterine cervical/endometrial cancer. Radiation Oncology, 18(1):193.
[8] Li, C., Lu, L., Zhang, J., Huang, S., Xing, Y., Zhao, M., ... & Meng, A. (2015). Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation. Cell & Bioscience, 5, 1-11.
[9] Schirrmacher, V. (2019). From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment. International journal of oncology, 54(2): 407-419.
[10] Coradduzza, D., Ghironi, A., Azara, E., Culeddu, N., Cruciani, S., Zinellu, A. & Carru, C. (2022). Role of Polyamines as Biomarkers in Lymphoma Patients: A Pilot Study. Diagnostics, 12(9): 2151.
https://doi.org/10.3892/ijo.2018.4661
[11] Mansoori, H., Faraz, M., Qadir, H., Rashid, A., & Ali, M. (2020). Precursor lymphoblastic lymphoma in the extramedullary tissue: a rare manifestation of chronic myeloid leukemia in blast crisis. Cureus, 12(10).
[12] Rezaieg, N. S. (2018). Consideration of Liver Function test with Erythropoietin Hormone Levels in Iraqi Patients Diagnosed with Lymphoid and Myeloid Leukemia. Iraqi Journal of Cancer and Medical Genetics, 11(1).
[13] Chinelo, O. V., Chukwuka, E., and Ifeoma, A. C. (2022). Causes of anemia due to diminished red blood cell production in pediatrics. International Journal of Scientific Advances (IJSCIA), 3(5): 711-718.
https://doi.org/10.51542/ijscia.v3i5.6.
[14] Ali, Z. M., Ali, S. H., & Mohsen, F. Y. (2020). Assessment of Some Hematological parameters in Iraqi Women with Different Breast Cancer Stages. Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683-3597 E-ISSN 2521-3512), 29(2): 99-106.
https://doi.org/10.31351/vol29iss2pp99-106
[15] Schneider, M., Potthoff, A. L., Scharnböck, E., Heimann, M., Schäfer, N., Weller, J. & Schuss, P. (2020). Newly diagnosed glioblastoma in geriatric (65+) patients: impact of patients frailty, comorbidity burden and obesity on overall survival. Journal of neuro-oncology, 149: 421-427.
[16] Huong, P. T., Nguyen, L. T., Nguyen, X. B., Lee, S. K., & Bach, D. H. (2019). The role of platelets in the tumor-microenvironment and the drug resistance of cancer cells. Cancers, 11(2): 240.
https://doi.org/10.3390/cancers11020240 [17] Hota, D., & Tripathy, A. (2022). Chemotherapy effects on immune system. In Cancer Diagnostics and Therapeutics: Current Trends, Challenges, and Future Perspectives (pp. 287-302). Singapore: Springer Singapore.
[18] Aziz, H. A. (2009). Effect of Radiation on Employers in Radiology (X-rays, CT Scan and Magnetic Resonance Imaging) In Al-muthanna Province-Iraq. Journal of Global Pharma Technology, 10(03):981-984.
[19] Chen, D., Patel, R. R., Verma, V., Ramapriyan, R., Barsoumian, H. B., Cortez, M. A., & Welsh, J. W. (2020). Interaction between lymphopenia, radiotherapy technique, dosimetry, and survival outcomes in lung cancer patients receiving combined immunotherapy and radiotherapy. Radiotherapy and Oncology, 150, 114-120.
https://doi.org/10.1016/j.radonc.2020.05.051
[20] Azkur, A. K., Akdis, M., Azkur, D., Sokolowska, M., van de Veen, W., Brüggen, M. C. and Akdis, C. A. (2020). Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19. Allergy, 75(7): 1564-1581.
[21] Tadesse, F. A., & Leminie, A. A. (2023). Effects of Adriamycin-Cytoxan
chemotherapy on hematological and electrolyte parameters among breast cancer patients. Frontiers in Oncology, 13, 1103013. https://doi.org/10.3389/fonc.2023.1103013
[22] Wassie, M., Aemro, A., & Fentie, B. (2021). Prevalence and associated factors of baseline anemia among cervical cancer patients in Tikur Anbesa Specialized Hospital, Ethiopia. BMC Women's Health, 21(1): 1-8.
[23] Coradduzza, D., Ghironi, A., Azara, E., Culeddu, N., Cruciani, S., Zinellu, A., and Carru, C. (2022). Role of Polyamines as Biomarkers in Lymphoma Patients: A Pilot Study. Diagnostics, 12(9): 2151. https://doi.org/10.3390/diagnostics12092151.
[24] Lee, C. L., Tsai, C. H., Yeh, D. C., Lin, C. S., Li, Y. F., and Tzeng, H. E. (2017). Hemoglobin level trajectories in the early treatment period are related with survival outcomes in patients with breast cancer. Oncotarget, 8(1): 1569–1579. https://doi.org/10.18632/oncotarget.13679.
[25] Jagieła, J., Bartnicki, P., and Rysz, J. (2021). Nephrotoxicity as a complication of chemotherapy and immunotherapy in the treatment of colorectal cancer, melanoma and non-small cell lung cancer. International Journal of Molecular Sciences, 22(9): 4618.
https://doi.org/10.3390/ijms22094618.
[26] Gupta, S., Portales-Castillo, I., Daher, A., & Kitchlu, A. (2021). Conventional chemotherapy nephrotoxicity. Advances in Chronic Kidney Disease, 28(5): 402-414.
https://doi.org/10.1053/j.ackd.2021.08.001.
[27] Rosner, M. H., Jhaveri, K. D., McMahon, B. A., & Perazella, M. A. (2021). Onconephrology: the intersections between the kidney and cancer. CA: a cancer journal for clinicians, 71(1): 47-77.
https://doi.org/10.3322/caac.21636.
[28] Gillessen, A., & Schmidt, H. H. J. (2020). Silymarin as supportive treatment in liver diseases: A narrative review. Advances in therapy, 37(4) : 1279-1301.
[29] Kobayashi, D., Yamamoto, K., Kimura, T., & Shimbo, T. (2022). Aspartate aminotransferase/alanine aminotransferase ratio and subsequent cancer development. Cancer medicine, 11(3):798-814.
[30] Kobayashi, D., Yamamoto, K., Kimura, T., & Shimbo, T. (2022). Aspartate aminotransferase/alanine aminotransferase ratio and subsequent cancer development. Cancer medicine, 11(3): 798-814.
[31] Wondimneh, B., Anekere Dasappa Setty, S., Gebregzabher Asfeha, G., Belay, E., Gebremeskel, G., & Baye, G. (2021). Comparison of hematological and biochemical profile changes in pre-and post-chemotherapy treatment of cancer patients attended at ayder comprehensive specialized hospital, mekelle, northern ethiopia 2019: A retrospective cohort study. Cancer Management and Research, 625-632.
https://doi.org/10.3390/diseases11010008.
[32] Jana, S., Mitra, P., and Roy, S. (2022). Proficient novel biomarkers guide early detection of acute kidney injury: A review. Diseases, 11(1): 8.
[33] Erdat, E. F. E., ARIK, Z., and BARIŞTA, İ. (2023). Biochemical Response Evaluation on Lymphomas: Proposing a Scoring System. UHOD-Uluslararasi Hematoloji-Onkoloji Dergisi, 33(3).
http://doi.org/10.4999/uhod.236946.
[34] Alkadhim Naji, B. A., Aliand, A. S., & Serhan Al-halaly, A. S. (2021). The Effect of Radiotherapy and Chemotherapy on Some Kidney and Liver Functions in Colorectal Cancer Patients. Medico-Legal Update, 21(2).
http://doi.org/10.37506/mlu.v21i2.2682 .
[35] Yang, X., Ren, H., Li, Z., Zhang, L., Shao, Y., Li, H., ... & Fu, J. (2022). A phase III randomized, controlled trial of nedaplatin versus cisplatin concurrent chemoradiotherapy in patients with cervical cancer. ESMO open, 7(5): 100565.
https://doi.org/10.1016/j.esmoop.2022.100565.
[36] Herrero, R., Sánchez, G., Asensio, I., López, E., Ferruelo, A., Vaquero, J., and Lorente, J. A. (2020). Liver–lung interactions in acute respiratory distress syndrome. Intensive Care Medicine Experimental, 8, 1-13.
[37] Ma, C., Yu, B., Zhang, H., Yang, B., Li, D., Li, R., and Lu, X. (2020). Non-Hodgkin’s lymphoma in an elderly patient with renal dysfunction: a case report. Journal of International Medical Research, 48(8): 0300060520945858.
https://doi.org/10.1177/0300060520945858.
[38] Storph, R. P., Ghartey, F. N., Ephraim, R. K., Mensah, E., Mornah, M., Ahenkorah-Fondjo, L. and Adu, P. (2019). The Effect of Chemotherapy on Clinical, Haematological
and Biochemical Profile in Breast Cancer Patients Undergoing Chemotherapy at Cape Coast Teaching Hospital; A Longitudinal Study.
[39] Mustafa, L. A., & Mohammad, Z. A. (2018). Study Levels of Some Biochemical Parameters in Serum of Pancreatic Cancer Patients. Tikrit Journal of Pure Science, 23(8): 62-65.
https://doi.org/10.25130/tjps.v23i8.544.
[40] Alabdullah, S. W., Albayati, S. J., & Yaseen, N. Y. (2016). The effect of a drug Cisplatin and Thymoquinone material in the liver of rats after the induced of cancer in laboratary. Tikrit Journal of Pure Science, 21(4): 53-59.