Study the effect of Atenolol drug in kidneys of Adult Swiss white mice
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In this study (40) mice were used from both sexes male and female and divided into experimental group and control, used (10) mice for each group treated with atenolol drug and (10) mice as a control group, and the therapeutic doses of the drug determined in three concentrations (0.02, 0.04, and 0.07 mg/Kg) the drug given orally by gavage once daily for month, after that the animals dissected and the blood sample were taken by heart puncture, for measurement the concentration of total creatinine, and also kidney taking for histological study. The results showed significant increases in concentration of creatinine in two doses (0.04 and 0.07 mg/Kg) when compared with control group. In addition to presence of many histological damaging in kidney tissue, such as necrosis of cell lining tubule, heamorrhage and congestion have spreaded in tissue, as well as damaging in glomerulus.
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