Synthesis and characterization of novel Mannich's bases incorporated with Ibuprofen an Biginelli Derivatives
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Abstract
In this work, a series of novel Mannich's bases incorporated with Ibuprofen core and Biginelli derivatives have been reported. The synthesis process was dependent on linking Ibuprofen hydrazone with Isatin to Biginelli derivatives via methylene group of formaldehyde. The new compounds have been characterized using FT-IR spectroscopy, 1H-NMR spectroscopy and the physical properties.
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References
[1] A. Toma, D. Hapău, M. Naghi, L. Vlase, C. Mogoşan and V. Zaharia, Stud. Univ. Babeş-Bolyai Ser. Chem., 2 (2013) 93-104. [2] S. Bala, N. Sharma, A. Kajal, S. Kamboj and V. Saini, Int. J. Med. Chem. 2014 Mar 4. Doi: 10.1155/2014/761030. [3] O. Bekircan and H. Bektas, Molecules 13 (2008) 2126-2135. [4] P. Karegoudar, M.S. Karthikeyan, D.J. Prasad and M. Mahalinga, B.S. Holla, N.S. Kumari, , Eur. J. Med. Chem., 43 (2008) 261-267. [5] B.S. Holla, B. Veerendra, M.K. Shivananda and B. Poojary, Eur. J. Med. Chem., 38 (2003) 759-767. [6] S.N. Thore, S.V. Gupta and K.G. Baheti, J. Saudi Chem. Soc.20 (2016) S46-S52 [7] F. Lopes, R. Capela, J.O. Goncaves, P.N. Horton, M.B. Hursthouse, J. Iley, C.M. Casimiro, J. Bom, R. Moreire, Tetrahedron Lett. 45 (2004) 7663-7666. [8] D. Sriram, T.R. Bal and P. Yogeesswari, Med. Chem. Res. 14 (2005) 11-28. [9] T. F. Cummings and J.R. Shelton, J. Org. Chem., 25(3) (1960) 419-423.
[10] C.O. Kappe, J. Zhu and H. Bienaymé (eds.): Multicomponent Reactions, Wiley-VCH, Weinheim, (2005) , 95-120
[11] C.O. Kappe, Tetrahedron 49 (32) (1993) 6937–6963.
[12] C.O. Kappe, Eur. J. Med. Chem. 35 (12) (2000) 1043-1052.
[13] A.D. Shutalev, E.A. Kishko, N. Sinova, A.Y. Kuznetsov, Molecules, 3 (3) (1998)100-106.
[14] A.I. Vogel, "Text book of practical organic chemistry" 3rd Ed. Longman group Ltd. London, (1974).288
[15] M. Amir, S. Kumar, Arch. Pharm. Chem. Life Sci. 338 (2005) 24-31.
[16] T.R. Belliotti, C.R. Xostlan, J.B. Kramer, J.C. Sircar, US. patent 4,981,865. (1991); Chem Abstr (1991), 114,206798x.
[17] M.S.Holden, R.D. Crouch, "The Microscale Laboratory", J.chem.Ed.78 (8) (2011) 1104.
[18] K. Chakkaravarthi, K. Gokulakrishnan, T. Suman, D. Tamilvendan, Int J Pharm Pharm Sci, 6(1) (2014) 492-495.
[19] S.N. Kulkarni, N. K. Bhamare, V. H. Kamath. "a new synthesis of ibuprofen", Indian Journal of chemistry, 28(11) (1989) 953-955.
[20] R.M. Silverstin, G.C. Bassler and T.C. Morril, "Spectrometric identification of organic compounds", 5th edn. Wiely,New York, (1991) 143-147
[21] F. Sweet and J. D. Fissekis, "Synthesis of 3,4-dihydro-2(1H)-pyrimidinones and the mechanism of the Biginelli reaction", J. Am. Chem. Soc. 95 (26) (1973) 8741–8749. [22] Xiong-Li Liu , Xiao-Mei Zhang and Wei-Cheng Yuan, "A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media", Tetrahedron letters, 52(8)( 2011) 903-906.