Study of honey bee effect on melatonin concentration and many immunological and biochemical parameters in women suffering Chronic kidney disease in Kirkuk city

Main Article Content

Wedad Mahmood L. Al-obaidi

Abstract

The present study designed to demonstrate positive effect for honey bee on melatonin conc. and some immunological and biochemical parameters in women suffering Chronic kidney disease (CKD), the study include (55) blood samples get from women with CKD , (21) women from them volunteered to eat natural honey for thirty days, compared with (20) samples for normal women as control with age (20-49)year ,the samples were collected from Kirkuk hospital and clinicals from febreuary/2015 to june/2015.


We reach to following conclusions: high significant increase in creatinin ,urea ,uric acid conc. And Melatonin ,MDA, Leptin ,IL-1α , IL-6 and TNF-α in women suffering from  CKD compared with control group. whereas we found high significant decreasing in Albumin, GSH, Ceruloplasmin conc. In  women with CKD compared with control . there were high significant decrease in biological ,immunological parameters with high significant increasing in Melatonin, Albumin, GSH, Ceruloplasmin in women with CKD and eat natural honey in compare with women with CKD without treatment with honey .

Article Details

How to Cite
Wedad Mahmood L. Al-obaidi. (2023). Study of honey bee effect on melatonin concentration and many immunological and biochemical parameters in women suffering Chronic kidney disease in Kirkuk city. Tikrit Journal of Pure Science, 21(2), 1–7. https://doi.org/10.25130/tjps.v21i2.966
Section
Articles

References

1-Stanisław, N.; Longin, N.; Katarzyna, P. and Ciepielewska,(2012). Basic endocrinological disorders in chronic renal failure. J. of Endocrinolog ; 63 (3):151-59.

2- Bucher, N. and Malt, R.( 1971) Regeneration of the liver and kidney. Boston: Little Brown, pp. 32–4.

3-Graves, J.W.( 2008) Diagnosis and Management of Chronic Kidney Disease. Mayo Clin Proc, 83(9):1064-1069.

4- Maurice, D., Katherine, L. Hull, A., C. Smith, J., Burton, S. and Nicolette, C.(2013) Inflammatory Factors and Exercise in chronic Kidney Disease

International Journal of Endocrinology Article ID 569831, 12.

5- Abeer, R. Abd A. and Sajida, H. Ismail. (2012). The Protective Effect of Honey Against Amikacin- induced Nephrotoxicity in Rats Iraqi J. Pharm Sci,21(2) . 6- Nguyen-Khoa T, Massy ZA, De Bandt J. (2001) Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant ; 16: 335–340. 7- Vidya M., Louise F., Jaswinder S., Gokhan H., Rosaire G., Stephan E., Humphries D. and Jonathan P.(2001). Adrenergic Regulation of IL-6 Release from Adipose Tissue: In Vivo and in Vitro Studies The Journal of Clinical Endocrinology & Metabolism 86(12):5864–5869 8- Escames, G. and Acuna-Castroviejo, D.(2009). Melatonin, synthetic analogs, and the sleep/wake rhythm. Rev. Neurol ;48:245-54.

9- Garcia-Maurino S., Gonzales –Haba M., Calvo, J.(1997). Melatonin enhance IL-2, IL-6 and IFN –g production by human circulating CD4+ cells J.Immunol.159:574-581.

10- Maestroni G.(2001). the immunotherapeutic potential of melatonin. Exp. Opin Invest Drugs.10:467-476.

11- Pozo, D., Delagado, M., Fernandez-Santo, J.(1997). Expression of melatonin receptors mRNA in T and B subsets of lymphocytes from rat thymus and spleen .FASEBJ.,11:466-473.

12- Garcia-Maurino S., Gonzales –Haba M., Calvo, J.(1998). Involvment of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6production in humon blood mononuclear cells. J. Neuroimmunol., 92:76-84. 13- Pedraza-Chaveri J, Maldonado PD, Medina-Campos O.( 2000). Garlic ameliorates gentamicin nephrotoxicit: Relation antioxidant enzymes. Exp physiology,29:602-611. 14 - Saravan, a K. J. and Mahitosh, M. (2009). Antiproliferative effect of honey and of polyphenols. Biomedicine and Biotechnology;34: 1-10. 15- Heba M Halawa, Nagwa E El-Nefiawy, Noha A Makhlouf and Awatef A. Mady (2009). Evalution of honey protective effect on lead induced oxidative stress in rats. JASMR; 2: 197-209.

16-Sedlak,J. and Lindsay, R. H. (1968). Analytical biochemistry. pp:192. Cited by Al-Zamyle (2001).

17- Sunderman, F. W.; Nomato, S. (1970). Measurement of human serum ceruloplasmin by its para phenylendiamine oxidase activity. Clin. Chem. 16(11), 903-910.

18- Guidet,B. and shah,S.(1989). Am J. Physiol; 257(26):440. cited by Muslih, R., Al-Nimer, M. and Al-Zamely, O. (2002). The level of Malondialdehyde after activation with H2O2 and CuSO4 and inhibition by deferoxamine and Molsidomine in the serum of patient with acute Myocardial infarction. National journal of chemistry; 5: 139-148.

19- havali, S.; Samejima, M.; Uchida, K.; Morita, Y.and Fukuda, A(1999). Improved enzyme immunoassay method for melatonin: Application to the determination of serum Melatonin in Rats ,Sheep and Humans, Clinical Chemistry 54:690-692.

20- Aukrust, P.(1994) Serum levels of tumor necrosis factor-α (TNF-α) and soluble TNF receptors in human immunodeficiency virus type1infection-correlations to clinical immunologic, and virologic parameters. J. Inf. Dis. 169:420-424.

21- Maffei, M.(1995). Leptin Levels in Human and Rodent Measurement of Plasma Level Leptin and ob RNA in Obese and Weight Reduce Subjects. Nat. Med.1:1155. 22-Matsuo Y, Sawai H, Funahashi H, Takahashi H, Sakamoto M, Yamamoto M, Okada Y, Hayakawa T, Manabe T.(2004). Pancreas, (28):3 344-352. 23-Hirano, T., Akira, S., Taga, T. (1990).Biological and clinical aspects of interleukin 6. Immunol Today 11 443-449 .

24- Heinegard, D. and Tederstrom, G.(1973). Determination of serum creatinine by irect colorimetric method. Clin. Chem. Acta.,43:305-309.

25. Fawcett, JK and Scott, JE.( 1960). Determination of urea in blood or serum. J. Clin. Path. 13: 156-159.

26-Marije Russcher1, Birgit Koch2, Elsbeth Nagtegaal1, Karien van der Putten (2012).The role of melatonin treatment in chronic kidney disease

Frontiers in Bi]oscience 17, 2 644-2656.

27-Eduardo Scandinari Manzolli, Juliana Mara Serpeloni (2015). Protective Effects of the Flavonoid Chrysin against Methylmercury - Induced

Genotoxicity and Alterations of Antioxidant Status, In Vivo Oxidative Medicine and Cellular Longevity, Article ID 602360, 7.

28- Fisher, C. J. (2003). Organoselenium compounds as glutathione peroxi-dase mimics. B-180 Medical Laboratories Free Radical and Radiation Biology Program, University of Iowa. 77: 222.

29- Murray, R.; Granner, D.; Mayes, P. and Rodwell, V. (2000). Harper's Biochemistry 25th ed. Appleton and Lange, USA.

30- Verma, V.; Ramesh, V.; Tewari, S.; Gupta, R. and Sinha, N. (2005). Role of bilirubin, vitamin C and ceruloplasmin as anti-oxidants in coronary artery disease (CAD). Indian Journal of Clinical Biochemistry; 20(2): 68-74.

31- Sies, H. (1995). Oxidative stress: introductory remarks. Sies H., ed. Oxidative stress. New York: Academic, pp. 1 – 8.

32-Gora, D., Sandhya, M., Shiv, G. and Praveen, S. (2006). Oxidative stress, α-tocophrol, ascorbic acid and reduced glutathione status in schizophrenics. Indian Journal of Clinical Biochemistry, 21 (2) 34-38

33. Vilma, B., Petras, V., Violeta, C. (2007) Radical scavenging activity of different floral origion honey and bee bread phenolic extracts. Elsevier,30: 1-6.

34. Cristine F. E. Grael S.( 2010).In vitro study of antioxidant and scavenger properties of phenolic

compounds from lychnophora species. Maced J Med Sci; 33: 867-870.

35. Aldina k., et al(2009). The influence of L-ascorbic acid content on total antioxidant activity of bee-honey. European Journal of Scientific Research; 32: 95-101.

36-Kimata H.,(2007). Laughter elevates the level of breast–milk melatonin.J.Psychosom,Res.,62:699-702.

37- Shaji V., Kulkarni S., Agrewala J. (1998). Regulation of secretions of IL- 4 and IgGI isotype by melatonin –stimulated ovalbumin specific T cells Clin. Exp. Imunol.,111:181-185.

38- Escames G., Acuna-Castroviejo D, Lopez, L. (2006). Pharmacological utility in the treatment of septic shock:exper. and clini. evidence, J. Pharm Pharmacol,58:1153-1165.

39- Nosolova V., Zeman S., Tomaszewsk R.(2007). Protective effect of melatonin in acetic acid induced colitis in rats. J. Pineal Res.,42:364-70.

40- Jaworek J., Leja-Szpak A, Jaworek J., Nawrot-Porabka K.(2004). The circadian rhythm of melatonin modulates the severity of caerulein –induced pancreatitis in the rat. J. Pineal Res.,37:161-170.

41- Emanuela E. and Salvatore C. (2010). Antiinflammatory Activity of Melatonin in Central Nervous System Curr Neuropharmacol.; 8(3): 228–242.

42- Carrillo-Vico A, Lardone PJ, Naji L, Fernández-Santos JM, Martín-Lacave I, Guerrero JM, Calvo JR. (2005) Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of ro-/ anti-inflammatory cytokine network, protection against oxidative damage and antiapoptotic effects. J. Pineal Res. ;39:400–408.

43. Casha S, Yu WR, Fehlings MG.(2001). Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience.103 :203–218.

44- Shankar,1 Shirmila Syamala,2 Jie Xiao,1 and Paul Muntner.(2012), Clinical Study Relationship between Plasma Leptin Level and Chronic Kidney Disease Journal of Nephrolog (32)6.

45-Simón Navarrete, Marcelo Alarcón, Iván Palomo. (2015).Aqueous Extract of Tomato (Solanum lycopersicum L.) and Ferulic Acid Reduce the Expression of TNF-α and IL-1β in LPS-Activated

Macrophages .Molecules; 20(8): 15319-15329 .

46- Tahan G1, Gramignoli R, Marongiu F, Aktolga S, Cetinkaya A, Tahan V, Dorko K.. (2011).Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of

acetic-acid- induced colitis in rats., Dig Dis Sci. Mar;

56(3):715-20. doi:

47- Li, J.; Yu, J.; Yu, H.; Xu, X.; Yu, L.; Liu, J. and Luo, H.( 2005). Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm.185–193

48- A. J Tonks, R.A Cooper, K.P Jones, S Blair, J Parton, A Tonks. (2009). honey stimulates inflammatory cytokine production monocytes 21(5): 242– 24.