Synthesis and characterization heterocyclic of compounds derived fromamino pyridine substituted
Main Article Content
Abstract
In this study, heterocyclic derivatives of imidazole, pyrimidine, benzodiazepine, indole and benzimidazole were synthesized. These new compounds were formed through the condensation reaction between 2-aminopyridinederivative with4-phenylphenacyl bromide, chloroacetic acid, malonic acid, phthalic acid, isatin and o-phenylenediamine respectively. All of these compounds synthesized produced of good yield percentage, The synthesized compounds structures were characterized by FTIR, 1H- and 13C-NMR spectroscopy
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1. M., Baltork, M. Moghadam, S. Tangestaninejad, V., Mirkhani, M. Zolfigol and. S. Hojati, 2008. ″Silica Sulfuric Acid Catalyzed Synthesis of Benzoxazole, Benzimidazoles and Oxazolo [4,5- b]
pyridines Under Heterogeneous and Solvent-Free Conditions″, J. Iran. Chem. Soc.” 5, pp.S65- S70.
2.F., Hadizadeh, H., Hosseinzadeh, V., Shariaty, M., Seifi and S., Kazemi, 2008. ″Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxyamides in Forced Swimming Test Model″, Iranian Journal of Pharmaceutical Research 7(1), pp. 29-33.
3. A. Ashnagar, N., Naseri, and M., Amini, 2009. "Synthesis of 5,5-diphenyl-2,4- imidazolidinedione (Phenytoin)″, International Journal of ChemTech Research 1(1), pp. 47-52.
4. L. Thomas, "Heterocyclic Chemistry", 3rd Ed., 3, (2008).
5.F., Itoh, Y., Yoshioka, K., Yukishige, S., Yoshida, K., Ootsu and H., Akimoto, 2000. ″Nonglutamate Type Pyrrolo[2,3-d]pyrimidine Antifolate. III. Synthesis and Biological Properties of Nω-Masked Ornithine Analogs″, Chem. Pharm. Bull 48(9), pp. 1270-1280.
6.S., George, 2008. ″Synthesis and evaluation of the biological activities of some 3-{[5-(6- methyl-4-aryl-2- oxo - 1,2,3,4 – tetrahydropyrimidin – 5 - yl) -1,3,4 - oxadiazol-2-yl]imino} - 1,3 – dihydro - 2H-indol – 2 - one″, Acta Pharm. 58, pp. 119-129.
7. A., Dondoni; P., Merino, "Diastereoselective Homologation of D-(R)-Glyceraldehyde Acetonide using 2- (Trimethylsilyl)thiazole", Org. Synth. 72: 21; Coll. Vol. 9: 952, (1995).
8.D., Tan, R., Reiter, L., Manchester, M., Yan, M., El-Sawi, R., Sainz, J., Mayo, R., Kohen, M., Allerga and R., Hardeland, ″Chemical and physical properties and potential mechanisms: melatonin as a broad
spectrum antioxidant and free radical scavenger″, Curr. Top. Med. Chem. 2, pp. 181-197(2002).
9. A. R. Trivedi, A. B. Siddiqui and V. H. Shah, ARKOVIC, ii, 210-217, (2008).
10. D. Silva, S. Garden, and A. Pinto, J. Braz. Chem. Soc., 12(3), 237, 121(2001).
11. A. Varela –Fernandez, J.A. Varela, C. Saa, Synthesis of indoles, 44, 3285-3295 , (2012).
12. Y. Wei , I .Deb, N .Yoshikai , J. Am . Chem. Soc., 134 , 9098-9101, (2012).
13. B.V.S. Reddy, M .R. Reddy, Y. G. Rao, J.S. yadav , B .Srighar , Org. Lett., 15 , 464-467 , (2013).
14. S. Sridhar, N., Pandeya, S., Bajpal and H., Manjula, 1999. ″Synthesis and antibacterial and antiviral activities of isatin derivatives″, Indian Drugs 36, pp. 412-414.
15. N. Raman, J. D. Raja and A. Sakthivel, J. Chem. Sci., 19(4), 303-310, (2007).
16. M. M. Ismail, M. Abdel-Magid and M. M. Hassan, Chem. Pap., 58(2), 117-125, (2004).
17. K. Sztanke, K. Pasternak, M. Sztanke, B. Rajtar and A. M. Dacewicz, Bull. Vet. Inc. Pulawy, 51, 481-484, (2007).
18. G. Y. Kilcigil and N. Altanlar, Turk. J. Chem, 30, 223-228, (2006).
19. T. Rosu, A. Gulea, A. Nicolae and R. Georgescu, Molecules, 12, 782-796, (2007).
20. H. F. Hussien, M.sc., “Synthesis, Characterization and Biological Activity study of New Five, Six and Seven Heterocyclic Compounds Derived from 2- Aminopyridine”, College of Science Al-Nahrain University, (2008).
21. Ş. Bahceci, B. Bahceci, N. İnce and A. İkizler, Turk. J. Chem., 22, 237-241, (1998).
22. C. C. Lindsy, B. M. Bolye, S. J. Mercede and T.
R. Pettus, Tetrahedron Lett., 45, 867-872, (2004).
23. I. O. Zhuravel, S. M. Kovalenko, S. V. Vlasov and V. P. Chernykh, Molecules, 10, 444–456, (2005).
24. S. Bahceci, B. Bahceci, N. İnce and A. İkizler, Turk. J. Chem., 22, 237-241, (1998).