Study of follistatin and sex hormones level in women with polycystic ovarian sayndrome in Baghdad
Main Article Content
Abstract
The aim of this search was to study the levels of follistatin and a number of sex hormones of polycystic ovary syndrome patients (PCOS).The study included 70 blood samples of women infected with PCOS and 20 samples from healthy women as control. The study had been perfigureed in Baghdad / Kamal al-Samarrai Hospital. The patient had been diagnosed with ultrasound waves (sonar device) by specialized physicians in the hospital. The research requirements for the period from September 2016 to March 2017. The results showed high significant difference (p <0.01) in the concentration of follistatin in women with PCOS compared with healthy women. On the other hand, there was a significant decrease (p <0.01) in the concentration of follicle stimulating hormone (FSH) in women with PCOS compared to control. The results showed high significant increase (P<0.01) in the concentrations of prolactin hormone and testosterone hormone in patients with PCOS compared to control.
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
References
1. Legro, R.S. and Strauss, J.F. (2002). Molecular progress in infertility: polycystic ovarian syndrome. Fertil and Steril . 78: 569-576.
2. Gurnee; Grystal, L, and Illinois. (2009). Infertility with Polycystic ovaries. Advanced Fertility Center of Chicago ,S.C. all right (847) : 662-1818.
3. Gorry, A.; White, D.M. and Franks, S. (2006). Infertility in polycystic ovary syndrome. Springer. 30 (1): 27-33.
4. Flanagan, J.N.; Linder, K.; Mejhert, N.; Dungner ,E.; Wahlen, K.; Decaunes, P.; Ryden, M.; Bjorklund, P.; Arver, S.; Bhasin, S. et al. (2009) Role of follistatin in promoting adipogenesis in women. J Clin Endocrinol Metab .94:3003–3009.
5. Hansen, J.; Rinnov, A. and Krogh - Madsen R. et al. (2013) Plasma follistatin is elevated in patients with type 2 diabetes: relationship to hyperglycemia, hyperinsulinemia, and systemic low-grade inflammation Diabetes Metab Res Rev, 29:463–472 .
6. Hedger, M.P.; Winnall, W.R.; Philips, D.J. and Kretser, D.M. (2011) the regulation & function of activing & follistatin in inflammation and immunity. Vitam Horm 85:255-297.
Luciano, A. A. (1999) clinical presentation of hyprolactinemia J. Repro. Med, vol.(44): 2 supp) p 1085-1090.
7. Guyton and Hall (2016). Physiology Review.2nd Edition. Elsevier Saunders.
8. Isik,S.; Berker, D.; Tutuncu, Y.A.; Ozuguz, U.; Gokay, F.; Erden, G.; Ozcan, H.N.; Kucukler , F.K.; Aydin, Y. and Guler, S .(2012). Clinical and radiological findings in macroprolactinemia. Endocrine Apr; 41(2):327-33.
9. Freeman, M.; Kanyicska, B.; Lerant, A. and Nagy, G.(2000). Prolactin structure, function and regulation of secretion physiol. Rev. 80(4) 1523-1631.
10. Basheer, Saad Safloul (2003). SPSS Arab Institute for Training and Resea.
11. Suganthi, R.; Manonayaki, S. and Benazir, J.A.F. (2010) Follistatin concentration in women from Kerala with polycy stic ovary syndrome Iranian journal of Reproductive Medicine Vol.8. No.3 pp: 131-134.
12. El-Shafey, M.; Hegazy, M and El-Zahabi. M.(2016)Clinical significance of Follistatin in obese and none -obese Egyptain polycystic ovary patients gournal of Molercular pathophsiology Vol(2):10-14.
13. Zongji, S.; Ping, C.X.; Wanxiang, W.; Hong Mei,L. and Xinping, R. (2010). Correiaion analysis of B, follistatin and activing A inpatients With Ovary syndrome, African Jourmal of Microbiohogy Research Vol.4(12) pp.1295-1298.
14. Teede, H.; Ng, S.; Hedger, M. and Moran, L. (2013) Follistatin in polycystic ovary syndrome:relation to metabolic of hormonal markers ,metabolic:clinical of experimental 62(10):1394-1400.
15. Gibney, J.; Smith, T.P. and Mckenna, T.J. (2005). The impact on clinical practice of routine screening figure a cropt .
16. Biller, B. M. (2001) Diagnostic evaluation of hyper Prolactinemia J. Reprod. Med. 44 (12 suppr) :1093-1099.
17. Prabhaker, V.K. and Davis, J.R. (2008). Hyerprolactinaemia. Best. Pract. Res. Clin. Obest. G.
18. Ferrari, E.; Bossolo, P.A; Foppa, S.; Dalzano, M.; Comis, S.; Morelli, M.P; Peveri, V. and Mengozzi, A. (2009). Prolactin secretin in polycystic ovary syndrome . Circadian .
19. Nader, Reem Adib Mohamed (2010). Study of the relationship between hormone lactation and infertility among women in the city of Tikrit and its suburbs. Thesis Masters. Faculty of Science, University of Tikrit
20. Jamiel, Rana Riad (2007). Study of the symptoms of PCOS in women in Iraq. Master Thesis / Basra University / Faculty of Science
21. Lee, S.J. and Mc - Pherron, A.C. (2001) Regulation of myostatin active + tyand muscle growth. Proc Natl Acad Sci USA.98:9306–9311 .
22. Shaw, C.K. sites, K. Patterson, C.S.; Jamison, S. J. Degain, and Laber A.B. (1996) Follicle stimulating hormone increase FSH respetor, J. Endo. Vol (134) p:411-417.
23. Jimenez- Krassel, M. E. Winn, D. Burns, J. L. H. Ireland, and J. J. Ireland (2003) Evidence for a Negative intrafollicular Role for Inhibin in
Regulation of Estradiol Production by Granulosa Cells J Endocrinology Vol 144 (5)P: 1876 1886.
24. Melmed, S. and Jameson, L. (2004) In Harrison principes of internal medicin .16th ed New York Mc Graw Hill Professional.
25. Eldar-Geva, T; Groome, N.P; Margalioth, E.J.& Homburg, R.(2001) Follistatin and activi a serum concentrations in obese and non-obese patients with polycystic ovary syndrome. Hum Reprod, Vol 16 (pg 2552-2556) .
26. Veena,H.C.;Manjunatha, S.; Amruta, S. and Hiremath, B. S. (2014) Effect of PCOS on Lipid Profile Scholars Journal of Applied Medical Sciences (SJAMS) (Online) Sch. J. App. Med. Sci.,; 2(3D): 1153-1155.
27. Yildiz, B.O. and Gedik O. (2004) Assessment of glucose intolerance and insulin sensitivity in polycystic ovary syndrome. Reprod Biomed Online, 8(6): 649-656.
28. Thomas & Rebar, B.O. and Gedik O. (2004) Assessment of glucose intolerance and insulin sensitivity in polycystic ovary syndrome. Reprod Biomed Online, 8(6): 649-656.
29. Basson, R.; Alkaade, S. and Morley, J.E.(2003) The benefit and risks of testosterone replecment the rapy , J. Clinical Manag Vol. 5(3) :427-48.
30. Gubayler and Hall (2006) textbook of medical Physiology in:endocrinology and reproduction. 12th ed. Department of physiology and biophysics Jackson mississi PPI.
31. Inoue, S.; Zimmet, P. and Caterson, I.(2009). The Asia- Pacific perspective Redefining obesity and its treatment (Internat).
httpwww.diabetes.com.au.pdf) obesity .
32. King, J.(2006). Polycystic ovary syndrome. J. Midwifery women health; 51(6):415-42.
33. Hasan, A.; Gordon, C.M. (2007). Polycystic ovary syndrome update in adolescence. Cur. Opin. Pediator; 19(4):389-397.