Hits vitality of aqueous extracts of Borago officinalis Linn in the reduction of renal toxicity developed by hyhrogen peroxide in female rabbits
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Abstract
This study is conducted to determine the protective effect of aqueous extracts of Borago officinalis Linn and its impact as histological antioxidant and on some parameters on the functions of the kidny in female of the albino rabbits exposed to oxidative stress-induced by 5%H2O2. The study included 20 rabbits at age (4-5 months) and they are divided into 4 groups (5animals/ group). These groups were: the control group, borage aqueous extract,H2O2 group, H2O2 group + borage aqueous extract. The study measures some of physiological and biochemical parameters (like count of (RBCs), measures The concentration of urea and creatinine). At the end of the experiment, the animals are killing in a manner of slaughter, and the kidny is eradicated and saved in 10% formalin, then microscopic slides of it are prepared for the histological study.this results showed increased significantly in number of red blood corpus in H2O2 group while the group of aqueous extract and H2O2with extract did not appear the significant differences when compared with the control. increased significantly appers in urea concentration of H2O2 and H2O2 with extract while the aqueous extacrt did not appear significant difference when compared whith control group.this study showed increased significantly in creatinine concentration in H2O2 group while the result showed decrease significantly in aqueous extacrt and H2O2 whith extract group when compared whith control group.
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